DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7255 and GNP1

DIOPT Version :9

Sequence 1:	NP_001034016.1	Gene:	CG7255 / 39662	FlyBaseID:	FBgn0036493	Length:	1063	Species:	Drosophila melanogaster
Sequence 2:	NP_010796.1	Gene:	GNP1 / 852121	SGDID:	S000002916	Length:	663	Species:	Saccharomyces cerevisiae

Alignment Length:	594	Identity:	124/594 - (20%)
Similarity:	216/594 - (36%)	Gaps:	140/594 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SPWKVLTRRKNLQADGSEGETKLNRVLGLWDLTALGVGSTLGAGVYVLAGQIAKDQAGP-SVMIS 69
            ||.:...:::||:.......|.:           :.:|:.:|.|:.|...::. :.||| .::|.
Yeast   134 SPQEQEQKQENLKKSIKPRHTVM-----------MSLGTGIGTGLLVGNSKVL-NNAGPGGLIIG 186

  Fly    70 FA---------IAALASLLAGVCYAEFGARVPKAGSAYVYSYVCIGEFVAFVIGWNLILEYVIGT 125
            :|         |.|...|  .|.|::.      .|....|....:...:.|.:.|...|:::
Yeast   187 YAIMGSCVYCIIQACGEL--AVIYSDL------IGGFNTYPLFLVDPALGFSVAWLFCLQWL--- 240

  Fly   126 ASVCRGISLYLDSLLNDTLKYTFAEVAPMNVSFLGSYFDFLAFGLVVVFGVALAFGVETSTMANN 190
             .|| .:.|...|:   |:||....|.|       ..|..:.:.|:||..|   ||.:....|:.
Yeast   241 -CVC-PLELVTASM---TIKYWTTSVNP-------DVFVVIFYVLIVVINV---FGAKGYAEADF 290

  Fly   191 FVTCLNI-FILGFVIIA------GALKADY--SNWTVDPSTVSANSTIGSGGFFPFGFEGTLRGA 246
            |..|..| .|:||.|:|      ||....|  |.:..||.....::.|..       |:|.:...
Yeast   291 FFNCCKILMIVGFFILAIIIDCGGAGTDGYIGSKYWRDPGAFRGDTPIQR-------FKGVVATF 348

  Fly   247 ATCFFGFVGFDCIATTGEEVRNPRKNIP---KSILLSLLIIFLCYFGVSTVLTLMLPYYIQDV-- 306
            .|..|.|...:.:|.|..|..||||.||   |.::..:|.:||...   |::..::||....:
Yeast   349 VTAAFAFGMSEQLAMTASEQSNPRKAIPSAAKKMIYRILFVFLASL---TLVGFLVPYTSDQLLG 410

  Fly   307 -------NAPLPYAFEYVGWPVAMWIVTVGGLVGLLASLFGALFPLPRVMYSMAQDGLLFKFLGK 364
                   .:|...|....|..|....:....|:.:|:...||.:...|::.|:|:.|...|....
Yeast   411 AAGSATKASPYVIAVSSHGVRVVPHFINAVILLSVLSVANGAFYTSSRILMSLAKQGNAPKCFDY 475

  Fly   365 VSPRFRVPVTGSIVAALFTAAIAGLFDLSQLVSLLSIGTLLAYSVVAISIMLLRYMDYCEVDENP 429
            :....| |....:|:|||                         .|:|          :|...:
Yeast   476 IDREGR-PAAAMLVSALF-------------------------GVIA----------FCASSK-- 502

  Fly   430 GQREVRASETTSLTSSSERFTFGSVCTQLFNVHRVQEPNAISSRIVGVLSTLFCLISLGIGVLIM 494
             :.|...:...:::..|:.||:.::|.......|..:....|...||..|.        :|
Yeast   503 -KEEDVFTWLLAISGLSQLFTWITICLSHIRFRRAMKVQGRSLGEVGYKSQ--------VG---- 554

  Fly   495 QAHLLIASKEVWALTLLIVLVVLMLLVICLICLQPREARRRLFRVPFVPIVPAISIFINIYLMLQ 559
                      ||.....::::||.|:....:.:.|.....:|....|.....|:.|:|.:|:..:
Yeast   555 ----------VWGSAYAVLMMVLALIAQFWVAIAPIGGGGKLSAQSFFENYLAMPIWIALYIFYK 609

  Fly   560 LDTWTWIRF 568
            :....|..|
Yeast   610 VWKKDWSLF 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7255	NP_001034016.1	2A0303	9..581	CDD:273330	122/591 (21%)
CG7255	NP_001034016.1	AA_permease_C	537..580	CDD:290617	7/32 (22%)
GNP1	NP_010796.1	2A0310	146..626	CDD:273334	120/582 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345724
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1286
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	90	1.000	Inparanoid score	I1545
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.790