Protein Alignment CG7255 and SLC7A3

DIOPT Version :9

• Sequence 1: NP_001034016.1
• Gene: CG7255 / 39662
• FlyBaseID: FBgn0036493
• Length: 1063
• Species: Drosophila melanogaster
• Sequence 2: NP_001041629.1
• Gene: SLC7A3 / 84889
• HGNCID: 11061
• Length: 619
• Species: Homo sapiens
• Alignment Length: 612
• Identity: 274/612 - (44%)
• Similarity: 395/612 - (64%)
• Gaps: 33/612 - (5%)

  Fly     7 PWKV-------LTRRKNLQADGSEGETKLNRVLGLWDLTALGVGSTLGAGVYVLAGQIAKDQAGP 64
            ||:.       |.||:.|::  ...||:|.|.|...||.|||||||||||||||||::|||:|||
Human     2 PWQAFRRFGQKLVRRRTLES--GMAETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKDKAGP 64

  Fly    65 SVMISFAIAALASLLAGVCYAEFGARVPKAGSAYVYSYVCIGEFVAFVIGWNLILEYVIGTASVC 129
            |::|.|.:|||:|:|||:||||||||||::||||:||||.:||..||..||||||.||||||||.
Human    65 SIVICFLVAALSSVLAGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLILSYVIGTASVA 129

  Fly   130 RGISLYLDSLLNDTLKYTFAEVAPMNV-SFLGSYFDFLAFGLVVVFGVALAFGVETSTMANNFVT 193
            |..|...|:|:.:.:..|......::| ..|..|.||.|.|||::....||.|...|.:.....|
Human   130 RAWSSAFDNLIGNHISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGLLALGASESALVTKVFT 194

  Fly   194 CLNIFILGFVIIAGALKADYSNWTV-----DPSTVSANST-----IGSGGFFPFGFEGTLRGAAT 248
            .:|:.:||||:|:|.:|.|..||.:     :.:....|.|     :|||||.||||||.||||||
Human   195 GVNLLVLGFVMISGFVKGDVHNWKLTEEDYELAMAELNDTYSLGPLGSGGFVPFGFEGILRGAAT 259

  Fly   249 CFFGFVGFDCIATTGEEVRNPRKNIPKSILLSLLIIFLCYFGVSTVLTLMLPYYIQDVNAPLPYA 313
            ||:.|||||||||||||.:||:::||..|::||.:.||.||.||:.||||:|||.....:|||.|
Human   260 CFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAVSSALTLMMPYYQLQPESPLPEA 324

  Fly   314 FEYVGWPVAMWIVTVGGLVGLLASLFGALFPLPRVMYSMAQDGLLFKFLGKVSPRFRVPVTGSIV 378
            |.|:||..|.::|.||.|..|..||.|::||:|||:|:||:|||||:.|.::....|.|:..::|
Human   325 FLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAEDGLLFRVLARIHTGTRTPIIATVV 389

  Fly   379 AALFTAAIAGLFDLSQLVSLLSIGTLLAYSVVAISIMLLRYMDYCEVDENPGQREVRASETTSLT 443
            :.:..|.:|.||.|:.||.|:|||||||||:|:|.:::|||..  :.:...|: ||...| .::|
Human   390 SGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVLILRYQP--DQETKTGE-EVELQE-EAIT 450

  Fly   444 SSSERFTFGSVCTQLFNVHRVQEPNAISSRIVGVLSTLFCLISLGIGVLIMQAHL-LIASKEVWA 507
            :.||:.|...:...|.::     |..:|.:||.|.|:|..::...:.:::.|..: |::...:|
Human   451 TESEKLTLWGLFFPLNSI-----PTPLSGQIVYVCSSLLAVLLTALCLVLAQWSVPLLSGDLLW- 509

  Fly   508 LTLLIVLVVLMLL-VICLICLQPREARRRLFRVPFVPIVPAISIFINIYLMLQLDTWTWIRFGVW 571
             |.::||::|::: :|.:|..||:.:....|:||.:|::|.:|||:|||||:|:...||.|||||
Human   510 -TAVVVLLLLLIIGIIVVIWRQPQSSTPLHFKVPALPLLPLMSIFVNIYLMMQMTAGTWARFGVW 573

  Fly   572 MIVGIPVFLACWYLYDCKNPAKRNPER 598
            |::|..::......:..:......|.|
Human   574 MLIGFAIYFGYGIQHSLEEIKSNQPSR 600

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7255	NP_001034016.1	2A0303	9..581	CDD:273330	270/591 (46%)
		AA_permease_C	537..580	CDD:290617	23/42 (55%)
SLC7A3	NP_001041629.1	2A0303	9..591	CDD:273330	270/594 (45%)
		AA_permease_C	539..589	CDD:290617	23/49 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157300
Domainoid	1	1.000	463	1.000	Domainoid score	I475
eggNOG	1	0.900	-	-		E2759_KOG1286
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2925
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D421901at33208
OrthoFinder	1	1.000	-	-		FOG0000131
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100168
Panther	1	1.100	-	-	O	PTHR43243
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X81
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.700