DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7255 and SLC7A14

DIOPT Version :9

Sequence 1:	NP_001034016.1	Gene:	CG7255 / 39662	FlyBaseID:	FBgn0036493	Length:	1063	Species:	Drosophila melanogaster
Sequence 2:	NP_066000.2	Gene:	SLC7A14 / 57709	HGNCID:	29326	Length:	771	Species:	Homo sapiens

Alignment Length:	763	Identity:	264/763 - (34%)
Similarity:	383/763 - (50%)	Gaps:	129/763 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 TKLNRVLGLWDLTALGVGSTLGAGVYVLAGQIAKDQAGPSVMISFAIAALASLLAGVCYAEFGAR 90
            |||.:||...||.:|||||.:|.|:||::|.:||:.|||.|::||.|||:||:|:||||||||.|
Human    47 TKLAQVLTTVDLISLGVGSCVGTGMYVVSGLVAKEMAGPGVIVSFIIAAVASILSGVCYAEFGVR 111

  Fly    91 VPK-AGSAYVYSYVCIGEFVAFVIGWNLILEYVIGTASVCRGISLYLDSLLNDTLKYTFAE-VAP 153
            ||| .||||.||||.:||||||.|||||||||:||||:....:|...|||.|.|:....|: |..
Human   112 VPKTTGSAYTYSYVTVGEFVAFFIGWNLILEYLIGTAAGASALSSMFDSLANHTISRWMADSVGT 176

  Fly   154 MNVSFLG--SYFDFLAFGLVVVFGVALAFGVETSTMANNFVTCLNIFILGFVIIAGALKADYSNW 216
            :|....|  ||.|.||..:.|:..:.:|.||:.|...||.:..||:.:..|::|||....:...|
Human   177 LNGLGKGEESYPDLLALLIAVIVTIIVALGVKNSIGFNNVLNVLNLAVWVFIMIAGLFFINGKYW 241

  Fly   217 TVDPSTVSANSTIGSGGFFPFGFEGTLRGAATCFFGFVGFDCIATTGEEVRNPRKNIPKSILLSL 281
                         ..|.|.|.|:.|.|:||||||:.|:|||.|||||||.:||..:||.:|..||
Human   242 -------------AEGQFLPHGWSGVLQGAATCFYAFIGFDIIATTGEEAKNPNTSIPYAITASL 293

  Fly   282 LIIFLCYFGVSTVLTLMLPYYIQDVNAPLPYAFEYVGWPVAMWIVTVGGLVGLLASLFGALFPLP 346
            :|....|..||.:||||:|||..|..:||...|...|:..|.::|.:|.:.||..||.|:|||:|
Human   294 VICLTAYVSVSVILTLMVPYYTIDTESPLMEMFVAHGFYAAKFVVAIGSVAGLTVSLLGSLFPMP 358

  Fly   347 RVMYSMAQDGLLFKFLGKVSPRFRVPVTGSIVAALFTAAIAGLFDLSQLVSLLSIGTLLAYSVVA 411
            ||:|:||.|||||:||..||.....||...||:....|.:|.|..|..|:.::||||||||::|:
Human   359 RVIYAMAGDGLLFRFLAHVSSYTETPVVACIVSGFLAALLALLVSLRDLIEMMSIGTLLAYTLVS 423

  Fly   412 ISIMLLRYMDYCEVD--------ENPGQRE-VRA---SETTSLTSSSERFT-------------- 450
            :.::||||....::|        |:..::| :.|   .|..|..|..:.|:
Human   424 VCVLLLRYQPESDIDGFVKFLSEEHTKKKEGILADCEKEACSPVSEGDEFSGPATNTCGAKNLPS 488

  Fly   451 ----------------------FGSV------------------CTQLFNVH------------R 463
                                  :|:|                  ..:|...|            :
Human   489 LGDNEMLIGKSDKSTYNVNHPNYGTVDMTTGIEADESENIYLIKLKKLIGPHYYTMRIRLGLPGK 553

  Fly   464 VQEPNAISSRIVGVLSTLFCLISLGIGVLIMQAHLLIASKEV-----WALTLLIVLVVLMLLVIC 523
            :..|.|.:...|.:     |::.|.|.:.|..:.::..|..:     ||:.|::::|:|:..::.
Human   554 MDRPTAATGHTVTI-----CVLLLFILMFIFCSFIIFGSDYISEQSWWAILLVVLMVLLISTLVF 613

  Fly   524 LICLQPREARRRLFRVPFVPIVPAISIFINIYLMLQLDTWTWIRFGVWMIVGIPVFLACWYLYDC 588
            :|..||...::..:..|.:|.|||.::.:||||||:|.|.|||||.||..||:.::..    |..
Human   614 VILQQPENPKKLPYMAPCLPFVPAFAMLVNIYLMLKLSTITWIRFAVWCFVGLLIYFG----YGI 674

  Fly   589 KNPAKRNPERWDFYKALKGLQESREQEYHCISKESVLTLETQLKKSPSSSLNRIQNLSDVGDELV 653
            .|.......|.:      .|.:|..|.|......||        :...|.....::..|.|..
Human   675 WNSTLEISAREE------ALHQSTYQRYDVDDPFSV--------EEGFSYATEGESQEDWGGP-- 723

  Fly   654 EIKNANGKVFYVEDNKSENSTATLGSNPESPSREDEQSVIAMLDDVLN 701
                ...|.||.:......:.....|..:|.|:..:.|...:.:|.|:
Human   724 ----TEDKGFYYQQMSDAKANGRTSSKAKSKSKHKQNSEALIANDELD 767

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7255	NP_001034016.1	2A0303	9..581	CDD:273330	243/641 (38%)
CG7255	NP_001034016.1	AA_permease_C	537..580	CDD:290617	22/42 (52%)
SLC7A14	NP_066000.2	2A0303	48..677	CDD:273330	243/650 (37%)
		AA_permease_C	627..677	CDD:290617	23/53 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	736..771		6/32 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1286
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D439017at2759
OrthoFinder	1	1.000	-	-		FOG0000131
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X81
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.820