DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7255 and slc7a14b

DIOPT Version :9

Sequence 1:	NP_001034016.1	Gene:	CG7255 / 39662	FlyBaseID:	FBgn0036493	Length:	1063	Species:	Drosophila melanogaster
Sequence 2:	XP_684639.2	Gene:	slc7a14b / 556696	ZFINID:	ZDB-GENE-091113-47	Length:	756	Species:	Danio rerio

Alignment Length:	780	Identity:	261/780 - (33%)
Similarity:	394/780 - (50%)	Gaps:	143/780 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LQADGSEGETKLNRVLGLWDLTALGVGSTLGAGVYVLAGQIAKDQAGPSVMISFAIAALASLLAG 81
            |:..|....|:|..||...||.:|||||.:|.|:||:||.:||:.|||.|::||.|||:||:|:|
Zfish    36 LEGSGDLHGTRLASVLTTVDLVSLGVGSCVGTGMYVVAGLVAKEMAGPGVILSFIIAAVASILSG 100

  Fly    82 VCYAEFGARVPK-AGSAYVYSYVCIGEFVAFVIGWNLILEYVIGTASVCRGISLYLDSLLNDTL- 144
            |||||||.|||| .||||.||||.:||||||.|||||||||:||||:....:|...|||.|.|:
Zfish   101 VCYAEFGVRVPKTTGSAYTYSYVTVGEFVAFFIGWNLILEYLIGTAAGASALSSMFDSLANHTIS 165

  Fly   145 KYTFAEVAPMNVSFLG--SYFDFLAFGLVVVFGVALAFGVETSTMANNFVTCLNIFILGFVIIAG 207
            :|....:..:|....|  ||.|.||..:.:|..|.:|.||:.|...||.:..:|:.:..|:::||
Zfish   166 RYMINHLGTLNGLGKGEESYPDLLALLIALVVTVIIALGVKNSVSFNNVLNVVNLVVWVFMVLAG 230

  Fly   208 ALKADYSNWTVDPSTVSANSTIGSGGFFPFGFEGTLRGAATCFFGFVGFDCIATTGEEVRNPRKN 272
            ......:||.             .|.|.|:|:.|.::||||||:.|:|||.|||||||.::|..:
Zfish   231 LFFLSGANWE-------------GGRFLPYGWSGVMQGAATCFYAFIGFDIIATTGEEAKSPDTS 282

  Fly   273 IPKSILLSLLIIFLCYFGVSTVLTLMLPYYIQDVNAPLPYAFEYVGWPVAMWIVTVGGLVGLLAS 337
            ||.:|..||:.....|..||.:|||::||.:.|.:|||...|...|:....:||.||.:.||..|
Zfish   283 IPYAITASLVTCLTAYVSVSVILTLLVPYNLIDGDAPLMEMFADHGFLAGKYIVAVGAVAGLTVS 347

  Fly   338 LFGALFPLPRVMYSMAQDGLLFKFLGKVSPRFRVPVTGSIVAALFTAAIAGLFDLSQLVSLLSIG 402
            |.|:|||:|||:|:||.|||||:||..|||....||....|:....|.:|.|..|..|:.::|||
Zfish   348 LLGSLFPMPRVIYAMAGDGLLFRFLSFVSPHTETPVVACAVSGSLAALLALLVSLRDLIEMMSIG 412

  Fly   403 TLLAYSVVAISIMLLRY-------------------------MDYCEVD----------ENP--- 429
            |||||::|::.::||||                         |...|.|          |||
Zfish   413 TLLAYTLVSVCVLLLRYQPDRDGFTSFLTEEEEEERRRKEEMMAASEKDLNSPGGEEYAENPCGA 477

  Fly   430 ------GQRE--VRASETTSLTSSSERFTFGSVCTQLFNVHRVQEPNAISSRIVG---------- 476
                  |..|  :..|::....|.::.:..|.      |...|.:.:.:..|::|
Zfish   478 KNLPSKGDNETLIEKSDSGGYQSENQGYGVGE------NGIEVDDSDGLFKRVLGSHYYTIRMRL 536

  Fly   477 ----------------VLS--TLFCLISLGIGVLIMQAHLLIASKEVWA-LTLLIVLVVLMLLVI 522
                            |.|  .:|.:::..:..|::.....::....|| |..::.::|||:.::
Zfish   537 GLPNVSDKPTPATGRTVTSCVLIFFILTFFLWTLVIYGFDRVSGGARWAILPFILTIIVLMVTLL 601

  Fly   523 CLICLQPREARRRLFRVPFVPIVPAISIFINIYLMLQLDTWTWIRFGVWMIVGIPVFLACWYLYD 587
            .:|..||...::..:..|.||.||..::.:||||||:|.:.||:||.||..:|:.::    :.|.
Zfish   602 IIILRQPENPKKLPYMAPCVPFVPTAAMLVNIYLMLKLSSITWVRFVVWCSLGVLIY----FSYG 662

  Fly   588 CKNPAKRNPERWDFYKALKGLQESREQEYHCISKESVLTLETQLKKSPSSSLNRIQNLSDVGDEL 652
                      .|:....|    .:||:..|..|.:...|              .:.:..:|.:||
Zfish   663 ----------MWNSSLEL----SAREEAAHASSYQRYDT--------------EVDDSFNVEEEL 699

  Fly   653 VEIKNANGKVFYVEDNKSENSTA-TLGSNPESPSREDEQSVIAMLDDVLNAQDTQQGQQDLDLQQ 716
            ...:|.       ||.:.:...| ..|.:.:...:::|||     .:..:...|.:|.::||.::
Zfish   700 PPEENE-------EDGQYQGWAAEERGYHYQKQYQDEEQS-----HNYRSKGRTNKGFEELDNEE 752

Fly 717 716
Zfish 753 752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7255	NP_001034016.1	2A0303	9..581	CDD:273330	238/642 (37%)
CG7255	NP_001034016.1	AA_permease_C	537..580	CDD:290617	19/42 (45%)
slc7a14b	XP_684639.2	2A0303	26..666	CDD:273330	240/662 (36%)
slc7a14b	XP_684639.2	AA_permease_C	616..666	CDD:290617	21/63 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1286
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D439017at2759
OrthoFinder	1	1.000	-	-		FOG0000131
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X81
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.820