DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7255 and Slc7a5

DIOPT Version :9

Sequence 1:	NP_001034016.1	Gene:	CG7255 / 39662	FlyBaseID:	FBgn0036493	Length:	1063	Species:	Drosophila melanogaster
Sequence 2:	NP_059049.1	Gene:	Slc7a5 / 50719	RGDID:	620639	Length:	512	Species:	Rattus norvegicus

Alignment Length:	563	Identity:	130/563 - (23%)
Similarity:	231/563 - (41%)	Gaps:	121/563 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 RRKNLQA---DGS--EGE-TKLNRVLGLWDLTALGVGSTLGAGVYVLAGQIAKDQAGPSV-MISF 70
            |.|.|:|   ||:  ||| ..|.|.:.|.:..|:.||:.:|:|::|....:.|:...|.: ::.:
  Rat    26 REKMLEARRGDGADPEGEGVTLQRNITLINGVAIIVGTIIGSGIFVTPTGVLKEAGSPGLSLVVW 90

  Fly    71 AIAALASLLAGVCYAEFGARVPKAGSAYVYSYVCIGEFVAFVIGWNLILEYVIGTASVCRGISLY 135
            |:..:.|::..:||||.|..:.|:|..|.|.....|...||:..|..:|        :.|..|.|
  Rat    91 AVCGVFSIVGALCYAELGTTISKSGGDYAYMLEVYGSLPAFLKLWIELL--------IIRPSSQY 147

  Fly   136 LDSLLNDT--LKYTFAEV-APMNVSFLGSYFDFLAFGLVVVFGVALAFGVETSTMANNFVTCLNI 197
            :.:|:..|  ||..|... .|...:.|.:....|....|..:.|..|..|:.:..|...:....|
  Rat   148 IVALVFATYLLKPVFPTCPVPEEAAKLVACLCVLLLTAVNCYSVKAATRVQDAFAAAKLLALALI 212

  Fly   198 FILGFVIIAGAL-KADYSNWTVDPSTVSANSTIGS------GGFFPFGFEGTLRGAATCFFGFVG 255
            .:|||:.:...: :.|.||.....|....|..:|:      .|.|.:|                |
  Rat   213 ILLGFIQMGKDIGQGDASNLHQKLSFEGTNLDVGNIVLALYSGLFAYG----------------G 261

  Fly   256 FDCIATTGEEVRNPRKNIPKSILLSLLIIFLCYFGVSTVLTLMLPYYIQDVNAPL-------PYA 313
            ::.:....||:.||.:|:|.:|::||.|:.|.|     |||.:..:.....|..|       .:.
  Rat   262 WNYLNFVTEEMINPYRNLPLAIIISLPIVTLVY-----VLTNLAYFTTLSTNQMLTSEAVAVDFG 321

  Fly   314 FEYVGWPVAMWIVTVGGLVGL--LASLFGALFPLPRVMYSMAQDGLLFKFLGKVSPRFRVPVTGS 376
            ..::|  |..||:.|  .|||  ..|:.|:||...|:.:..:::|.|...|..:.|:...||...
  Rat   322 NYHLG--VMSWIIPV--FVGLSCFGSVNGSLFTSSRLFFVGSREGHLPSILSMIHPQLLTPVPSL 382

  Fly   377 IVAALFTAAIAGLFDLSQLVSLLSIGTLLAYSVVAISIMLLRYMDYCEVDENPG-QREVRASETT 440
            :...:.|...|...|:..:::..|....|..::..|.:|.||:       :.|. :|.::.:
  Rat   383 VFTCVMTLMYAFSRDIFSIINFFSFFNWLCVALAIIGMMWLRF-------KKPELERPIKVN--- 437

  Fly   441 SLTSSSERFTFGSVCTQLFNVHRVQEPNAISSRIVGVLSTLFCL--------ISLGIGVLIMQAH 497
                                         ::..:..:|:.||.:        :..|||..|:.:.
  Rat   438 -----------------------------LALPVFFILACLFLIAVSFWKTPLECGIGFAIILSG 473

  Fly   498 LLI-------ASKEVWALTLLIVLVVLMLLVIC--LICLQPRE 531
            |.:       .:|..|     |:.|:..:.|:|  |:.:.|:|
  Rat   474 LPVYFFGVWWKNKPKW-----ILQVIFSVTVLCQKLMQVVPQE 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7255	NP_001034016.1	2A0303	9..581	CDD:273330	130/563 (23%)
CG7255	NP_001034016.1	AA_permease_C	537..580	CDD:290617
Slc7a5	NP_059049.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..43		7/16 (44%)
Slc7a5	NP_059049.1	2A0308	23..511	CDD:273332	129/561 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351202
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.930