DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7255 and CG5535

DIOPT Version :9

Sequence 1:	NP_001034016.1	Gene:	CG7255 / 39662	FlyBaseID:	FBgn0036493	Length:	1063	Species:	Drosophila melanogaster
Sequence 2:	NP_649019.2	Gene:	CG5535 / 39990	FlyBaseID:	FBgn0036764	Length:	630	Species:	Drosophila melanogaster

Alignment Length:	623	Identity:	284/623 - (45%)
Similarity:	407/623 - (65%)	Gaps:	46/623 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 WKVLTRRKNLQADGSEGETKLNRVLGLWDLTALGVGSTLGAGVYVLAGQIAKDQAGPSVMISFAI 72
            ::||||:|.|:   ...|:||.:||..:||||||:|||||.|||||||:::|..|||:|::||.|
  Fly    19 FRVLTRKKPLE---DSNESKLAKVLSAFDLTALGIGSTLGVGVYVLAGEVSKQYAGPAVVVSFLI 80

  Fly    73 AALASLLAGVCYAEFGARVPKAGSAYVYSYVCIGEFVAFVIGWNLILEYVIGTASVCRGISLYLD 137
            ||:||:.||:||||||||||||||||:||||.||||:||:|||||||||.||:|||.:|:|.|||
  Fly    81 AAIASIFAGLCYAEFGARVPKAGSAYIYSYVTIGEFIAFLIGWNLILEYAIGSASVVKGLSTYLD 145

  Fly   138 SLLNDTLKYTFAEVAPMNVSFLGSYFDFLAFGLVVVFGVALAFGVETSTMANNFVTCLNIFILGF 202
            .|..:.:........|:|:..:|:|.|..||.:.::|.:|:|.|.:.||..||..|.||:.::.|
  Fly   146 QLCGNPMSSFLGTHMPLNIEGMGAYPDLFAFVVTILFSLAIAVGAKESTRVNNVFTMLNLGVVLF 210

  Fly   203 VIIAGALKADYSNWTVDPSTVSANSTIGSGGFFPFGFEGTLRGAATCFFGFVGFDCIATTGEEVR 267
            |||||..|...|||::..|.|...  .|.|||.|:|..|.::|||.||:||:|||||||.|||.:
  Fly   211 VIIAGLFKVSSSNWSIPKSQVPEG--YGDGGFMPYGVSGIIKGAAVCFYGFIGFDCIATAGEEAK 273

  Fly   268 NPRKNIPKSILLSLLIIFLCYFGVSTVLTLMLPYYIQDVNAPLPYAFEYVGWPVAMWIVTVGGLV 332
            ||:|:||.::::||.:|||.|||||||||:||||:.||..||||:.|...||.||.::|::|.:.
  Fly   274 NPKKSIPFAVIVSLAMIFLAYFGVSTVLTMMLPYFEQDEKAPLPHVFRINGWHVAEYVVSIGAMF 338

  Fly   333 GLLASLFGALFPLPRVMYSMAQDGLLFKFLGKVSPRFRVPVTGSIVAALFTAAIAGLFDLSQLVS 397
            ||.:|:.||:|||||::::|:.|||||||||.:|.:::.|..|:::..:.|..:|.:|:|||||:
  Fly   339 GLCSSMMGAMFPLPRIVFAMSNDGLLFKFLGDISEKYKTPFKGTMITGMLTGILAAVFNLSQLVN 403

  Fly   398 LLSIGTLLAYSVVAISIMLLRYMDYCEVDENPGQREVRASETTSLTSSSERFTFGSVCTQLFNVH 462
            ::|||||||||:||..:::|||    |||:....|.|.....|.|    |:....::..::||::
  Fly   404 MMSIGTLLAYSMVASCVLMLRY----EVDDRRESRIVANGRATGL----EQDRPCALWRRIFNLN 460

  Fly   463 RVQEPNAISSRIVGVLSTLFCLISLGIGVLIMQAHLLIASKEVWALTLLIVLVVLMLLVICLICL 527
            ....|...:||||....|||.|..:....::.:....:|:...:....|::..:.:.:::.:|..
  Fly   461 GQTVPTKQTSRIVTYSVTLFSLWCMVFSQILTKFEEDLANVTSFDGIKLVLGTIPLAVLLLVISR 525

  Fly   528 QPREARRRLFRVPFVPIVPAISIFINIYLMLQLDTWTWIRFGVWMIVGIPVFLACWY-------- 584
            ||....:..|:||.||.:|.|||.||||||::||..|||||.:|:.:|:.:|||  |
  Fly   526 QPTSGVKLSFKVPLVPWLPGISILINIYLMIKLDILTWIRFSIWIAIGLAIFLA--YGIRHSRLR 588

  Fly   585 -----------LYDCKNPAKRNPERWDFYKALKGLQES 611
                       :.||.|            .||.|.||:
  Fly   589 QREQRNNSIAMMRDCSN------------SALLGGQEN 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7255	NP_001034016.1	2A0303	9..581	CDD:273330	273/571 (48%)
CG7255	NP_001034016.1	AA_permease_C	537..580	CDD:290617	24/42 (57%)
CG5535	NP_649019.2	2A0303	20..585	CDD:273330	276/579 (48%)
CG5535	NP_649019.2	AA_permease_C	535..585	CDD:290617	28/51 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469329
Domainoid	1	1.000	307	1.000	Domainoid score	I322
eggNOG	1	0.900	-	-		E2759_KOG1286
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	352	1.000	Inparanoid score	I609
Isobase	1	0.950	-	0	Normalized mean entropy	S2925
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D40603at33392
OrthoFinder	1	1.000	-	-		FOG0000131
OrthoInspector	1	1.000	-	-		mtm14985
orthoMCL	1	0.900	-	-		OOG6_100168
Panther	1	1.100	-	-	P	PTHR43243
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X81
	12	11.750