DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7255 and Slc7a4

DIOPT Version :9

Sequence 1:	NP_001034016.1	Gene:	CG7255 / 39662	FlyBaseID:	FBgn0036493	Length:	1063	Species:	Drosophila melanogaster
Sequence 2:	NP_001100548.1	Gene:	Slc7a4 / 303787	RGDID:	1305905	Length:	635	Species:	Rattus norvegicus

Alignment Length:	604	Identity:	235/604 - (38%)
Similarity:	346/604 - (57%)	Gaps:	62/604 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LTRRKNLQADGSEGETKLNRVLGLWDLTALGVGSTLGAGVYVLAGQIAKDQAGPSVMISFAIAAL 75
            |.|.|.|:.  |..||.|.|.|...|||.||||..:|:|:|||.|.:|||.|||:|::||.:||:
  Rat    18 LNRLKPLEE--SSTETSLRRCLSTLDLTLLGVGGMVGSGLYVLTGTVAKDMAGPAVLLSFLVAAV 80

  Fly    76 ASLLAGVCYAEFGARVPKAGSAYVYSYVCIGEFVAFVIGWNLILEYVIGTASVCRGISLYLDSLL 140
            |||||.:||||||||||:.||||:::||.:||..||:||||::|||:||.|:|.|..|.|||::.
  Rat    81 ASLLAALCYAEFGARVPRTGSAYLFTYVSMGEIWAFLIGWNVLLEYLIGGAAVARAWSGYLDAIF 145

  Fly   141 NDTLK-YTFAEVAPMNVSFLGSYFDFLAFGLVVVFGVALAFGVETSTMANNFVTCLNIFILGFVI 204
            |.::: :|.:.:....:.||..|.||||.|:::|....::.|...|:..|:..:.:::.::.|:|
  Rat   146 NHSIRNFTESHMGVWQMPFLAHYPDFLAAGILLVASAFVSCGARVSSWLNHTFSAISLIVILFII 210

  Fly   205 IAGALKADYSNWTVDPSTVSANSTIGSGGFFPFGFEGTLRGAATCFFGFVGFDCIATTGEEVRNP 269
            :.|.:.|...||:.:           .|||.||||.|.|.|.||||:.|||||.||.:.||.:||
  Rat   211 VLGFILARPHNWSAE-----------EGGFAPFGFSGILAGTATCFYAFVGFDVIAASSEEAKNP 264

  Fly   270 RKNIPKSILLSLLIIFLCYFGVSTVLTLMLPYYIQDVNAPLPYAFEYVGWPVAMWIVTVGGLVGL 334
            |..:|.:|.:||.:....|..||||||||:|::..|.::.|..||...|:..|.:||.||.:..:
  Rat   265 RWAVPMAIAISLGLAAGAYILVSTVLTLMVPWHSLDPDSALADAFYRRGYGWAGFIVAVGSICAM 329

  Fly   335 LASLFGALFPLPRVMYSMAQDGLLFKFLGKVSPRFRVPVTGSIVAALFTAAIAGLFDLSQLVSLL 399
            ...|...||.|||::|:||.|||.|:...:|.||.:|||.|.:|..:..|.:|.|.||..||..|
  Rat   330 NTVLLSNLFSLPRIVYAMAADGLFFQVFARVHPRTQVPVVGILVFGVLMALLALLMDLEALVQFL 394

  Fly   400 SIGTLLAYSVVAISIMLLRYMDYCEVDENPGQREVRASETTSLTSSSERFT---FGSVCTQLFNV 461
            ||||||||:.||.||::||:.              :||..:|...:|...|   :.|....:..|
  Rat   395 SIGTLLAYTFVATSIIVLRFQ--------------KASPPSSPCPASPGPTVKKYDSFSDHIQLV 445

  Fly   462 HRVQ----EPNAISSRIVGVLSTLFCL-----ISLGIGVLIMQA--------------HLLIASK 503
            ..||    ||..:...:...|..|..|     ::..:|:||..|              ||
  Rat   446 DAVQASMSEPGQLRPALKPFLGFLDGLSPGTAVTWALGILIASAISLACVLVFGNSALHL----- 505

  Fly   504 EVWALTLLIVLV-VLMLLVICLICLQPREARRRLFRVPFVPIVPAISIFINIYLMLQLDTWTWIR 567
            ..|...||:|:. .:.|..:.::....::.::..|::|.||:.||:||.:|:.|||:|...||:|
  Rat   506 PRWGYVLLLVVSGAVFLSSLLVLGAHQQQKKQDTFQIPLVPLTPALSILLNLCLMLKLSYLTWLR 570

  Fly   568 FGVWMIVGIPVFL--ACWY 584
            |..|::||:.|:.  ..|:
  Rat   571 FIFWLLVGLVVYFGYGIWH 589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7255	NP_001034016.1	2A0303	9..581	CDD:273330	234/599 (39%)
CG7255	NP_001034016.1	AA_permease_C	537..580	CDD:290617	21/42 (50%)
Slc7a4	NP_001100548.1	2A0303	14..592	CDD:273330	235/604 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351212
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1286
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000131
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100168
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X81
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.640