DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7255 and Slc7a14

DIOPT Version :9

Sequence 1:	NP_001034016.1	Gene:	CG7255 / 39662	FlyBaseID:	FBgn0036493	Length:	1063	Species:	Drosophila melanogaster
Sequence 2:	NP_766449.1	Gene:	Slc7a14 / 241919	MGIID:	3040688	Length:	771	Species:	Mus musculus

Alignment Length:	763	Identity:	262/763 - (34%)
Similarity:	386/763 - (50%)	Gaps:	129/763 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 TKLNRVLGLWDLTALGVGSTLGAGVYVLAGQIAKDQAGPSVMISFAIAALASLLAGVCYAEFGAR 90
            |||.:||...||.:|||||.:|.|:||::|.:||:.|||.|::||.|||:||:|:||||||||.|
Mouse    47 TKLAQVLTTVDLISLGVGSCVGTGMYVVSGLVAKEMAGPGVIVSFIIAAVASILSGVCYAEFGVR 111

  Fly    91 VPK-AGSAYVYSYVCIGEFVAFVIGWNLILEYVIGTASVCRGISLYLDSLLNDTL-KYTFAEVAP 153
            ||| .||||.||||.:||||||.|||||||||:||||:....:|...|||.|.:: ::....|..
Mouse   112 VPKTTGSAYTYSYVTVGEFVAFFIGWNLILEYLIGTAAGASALSSMFDSLANHSISRWMVDTVGT 176

  Fly   154 MNVSFLG--SYFDFLAFGLVVVFGVALAFGVETSTMANNFVTCLNIFILGFVIIAGALKADYSNW 216
            :|....|  ||.|.||..:.|:..:.:|.||:.|...||.:..||:.:..|::|||....:...|
Mouse   177 LNGLGKGEESYPDLLALVIAVIVTIIVALGVKNSVGFNNVLNVLNLAVWVFIMIAGLFFINGKYW 241

  Fly   217 TVDPSTVSANSTIGSGGFFPFGFEGTLRGAATCFFGFVGFDCIATTGEEVRNPRKNIPKSILLSL 281
                         ..|.|.|.|:.|.|:||||||:.|:|||.|||||||.:||..:||.:|..||
Mouse   242 -------------AEGQFLPHGWSGVLQGAATCFYAFIGFDIIATTGEEAKNPNTSIPYAITASL 293

  Fly   282 LIIFLCYFGVSTVLTLMLPYYIQDVNAPLPYAFEYVGWPVAMWIVTVGGLVGLLASLFGALFPLP 346
            :|....|..||.:||||:|||..|..:||...|...|:..|.::|.:|.:.||..||.|:|||:|
Mouse   294 VICLTAYVSVSMILTLMVPYYAIDTESPLMEMFVAHGFYAAKFVVAIGSVAGLTVSLLGSLFPMP 358

  Fly   347 RVMYSMAQDGLLFKFLGKVSPRFRVPVTGSIVAALFTAAIAGLFDLSQLVSLLSIGTLLAYSVVA 411
            ||:|:||.|||||:||..||.....||...||:....|.::.|..|..|:.::||||||||::|:
Mouse   359 RVIYAMAGDGLLFRFLAHVSSYTETPVVACIVSGFLAALLSLLVSLRDLIEMMSIGTLLAYTLVS 423

  Fly   412 ISIMLLRYMDYCEVD--------ENPGQRE-VRA---SETTSLTSSSERFT-------------- 450
            :.::||||....::|        |:..::| :.|   .||.|..|..|.|:
Mouse   424 VCVLLLRYQPESDIDGFVKFLSEEHTKKKEGILADCEKETCSPVSEGEEFSSPATNTCGAKNLPS 488

  Fly   451 -------FGSVCTQLFNVH---------------------------------------------R 463
                   .|......:||:                                             :
Mouse   489 LGDNEMLIGKSDKSAYNVNHPNYGTVDMTTGIEADESENIYLIKLKKLIGPRYYTMRIRLGLPGK 553

  Fly   464 VQEPNAISSRIVGVLSTLFCLISLGIGVLIMQAHLLIASKEV-----WALTLLIVLVVLMLLVIC 523
            :..|.|.:...|.:     |::.|.|.:.|..:.::..|:.:     ||:.|::::::|:.:::.
Mouse   554 MDRPTAATGHTVTI-----CVLLLFILMFIFCSFIIFGSEYISGQSWWAILLVVLMMLLISVLVF 613

  Fly   524 LICLQPREARRRLFRVPFVPIVPAISIFINIYLMLQLDTWTWIRFGVWMIVGIPVFLACWYLYDC 588
            :|..||...::..:..|.:|.|||.::.:||||||:|.|.|||||.||..||:.::..    |..
Mouse   614 VILQQPENPKKLPYMAPCLPFVPAFAMLVNIYLMLKLSTITWIRFAVWCFVGMLIYFG----YGI 674

  Fly   589 KNPAKRNPERWDFYKALKGLQESREQEYHCISKESVLTLETQLKKSPSSSLNRIQNLSDVGDELV 653
            .|.......|      .:.|.:|..|.|......||        :...|.....::..|.|..
Mouse   675 WNSTLEISAR------EQALHQSTYQRYDVDDPFSV--------EEGFSYATEGESQEDWGGP-- 723

  Fly   654 EIKNANGKVFYVEDNKSENSTATLGSNPESPSREDEQSVIAMLDDVLN 701
                |..|.||.:......:.:...|..:|.|:..:.|...:.:|.|:
Mouse   724 ----AEDKGFYYQQMSDAKANSRTSSKAKSKSKHKQNSEALIANDELD 767

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7255	NP_001034016.1	2A0303	9..581	CDD:273330	240/641 (37%)
CG7255	NP_001034016.1	AA_permease_C	537..580	CDD:290617	22/42 (52%)
Slc7a14	NP_766449.1	2A0303	43..677	CDD:273330	241/651 (37%)
Slc7a14	NP_766449.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	735..771		6/33 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1286
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000131
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X81
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.810