DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7255 and SLC7A11

DIOPT Version :9

Sequence 1:	NP_001034016.1	Gene:	CG7255 / 39662	FlyBaseID:	FBgn0036493	Length:	1063	Species:	Drosophila melanogaster
Sequence 2:	XP_011530104.1	Gene:	SLC7A11 / 23657	HGNCID:	11059	Length:	506	Species:	Homo sapiens

Alignment Length:	425	Identity:	97/425 - (22%)
Similarity:	176/425 - (41%)	Gaps:	62/425 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 NLQADGSEGETKLNRVLGLWDLTALGVGSTLGAGVYVLAGQIAKD--QAGPSVMISFAIAALASL 78
            |.:..|.| :.:|.|.:.|....::.:|:.:|||:::....:.::  ..|.|:.| :.:..:.||
Human    29 NKEPPGQE-KVQLKRKVTLLRGVSIIIGTIIGAGIFISPKGVLQNTGSVGMSLTI-WTVCGVLSL 91

  Fly    79 LAGVCYAEFGARVPKAGSAYVYSYVCIGEFVAFVIGW-NLILEYVIGTASVCRGISLYLDSLLND 142
            ...:.|||.|..:.|:|..|.|.....|...|||..| .|::.....||.:......|:
Human    92 FGALSYAELGTTIKKSGGHYTYILEVFGPLPAFVRVWVELLIIRPAATAVISLAFGRYI------ 150

  Fly   143 TLKYTF--AEVAPMNVSFLGSYFDFLAFGLVVVFGVALAFGVETSTMANNFVTCLNIFILGFVII 205
             |:..|  .|:..:.:..:      .|.|:.||. |..:..|..|.....|:|...:..:..:|:
Human   151 -LEPFFIQCEIPELAIKLI------TAVGITVVM-VLNSMSVSWSARIQIFLTFCKLTAILIIIV 207

  Fly   206 AGA---LKADYSNWTVDPSTVSANSTIGSGGFFPFGFEGTLRGAATCFFG---FVGFDCIATTGE 264
            .|.   :|....|:  ..:....:|:|..   .|..|          ::|   :.|:..:....|
Human   208 PGVMQLIKGQTQNF--KDAFSGRDSSITR---LPLAF----------YYGMYAYAGWFYLNFVTE 257

  Fly   265 EVRNPRKNIPKSILLSLLIIFLCYFGVSTVLTLMLPYYIQDVNA---------PLPYAFEYVG-W 319
            ||.||.|.||.:|.:|:.|:.:.|     |||.:.  |...:||         .:.::...:| :
Human   258 EVENPEKTIPLAICISMAIVTIGY-----VLTNVA--YFTTINAEELLLSNAVAVTFSERLLGNF 315

  Fly   320 PVAMWIVTVGGLVGLLASLFGALFPLPRVMYSMAQDGLLFKFLGKVSPRFRVPVTGSIVAALFTA 384
            .:|:.|...   :....|:.|.:|.:.|:.|..:::|.|.:.|..:..|...|:...||....|.
Human   316 SLAVPIFVA---LSCFGSMNGGVFAVSRLFYVASREGHLPEILSMIHVRKHTPLPAVIVLHPLTM 377

  Fly   385 AIAGLFDLSQLVSLLSIGTLLAYSVVAISIMLLRY 419
            .:....||..|::.||....|...:....::.|||
Human   378 IMLFSGDLDSLLNFLSFARWLFIGLAVAGLIYLRY 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7255	NP_001034016.1	2A0303	9..581	CDD:273330	97/425 (23%)
CG7255	NP_001034016.1	AA_permease_C	537..580	CDD:290617
SLC7A11	XP_011530104.1	2A0308	1..483	CDD:273332	97/425 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157269
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840