DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7255 and Slc7a5

DIOPT Version :9

Sequence 1:	NP_001034016.1	Gene:	CG7255 / 39662	FlyBaseID:	FBgn0036493	Length:	1063	Species:	Drosophila melanogaster
Sequence 2:	NP_035534.2	Gene:	Slc7a5 / 20539	MGIID:	1298205	Length:	512	Species:	Mus musculus

Alignment Length:	563	Identity:	129/563 - (22%)
Similarity:	230/563 - (40%)	Gaps:	121/563 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 RRKNLQA---DGS--EGE-TKLNRVLGLWDLTALGVGSTLGAGVYVLAGQIAKDQAGPSV-MISF 70
            |.|.|:|   ||:  ||| ..|.|.:.|.:..|:.||:.:|:|::|....:.|:...|.: ::.:
Mouse    26 REKMLEARRGDGADPEGEGVTLQRNITLLNGVAIIVGTIIGSGIFVTPTGVLKEAGSPGLSLVVW 90

  Fly    71 AIAALASLLAGVCYAEFGARVPKAGSAYVYSYVCIGEFVAFVIGWNLILEYVIGTASVCRGISLY 135
            |:..:.|::..:||||.|..:.|:|..|.|.....|...||:..|..:|        :.|..|.|
Mouse    91 AVCGVFSIVGALCYAELGTTISKSGGDYAYMLEVYGSLPAFLKLWIELL--------IIRPSSQY 147

  Fly   136 LDSLLNDT--LKYTFAEV-APMNVSFLGSYFDFLAFGLVVVFGVALAFGVETSTMANNFVTCLNI 197
            :.:|:..|  ||..|... .|...:.|.:....|....|..:.|..|..|:.:..|...:....|
Mouse   148 IVALVFATYLLKPVFPTCPVPEEAAKLVACLCVLLLTAVNCYSVKAATRVQDAFAAAKLLALALI 212

  Fly   198 FILGFVIIAGAL-KADYSNWTVDPSTVSANSTIGS------GGFFPFGFEGTLRGAATCFFGFVG 255
            .:|||:.:...: :.|.||.....|....|..:|:      .|.|.:|                |
Mouse   213 ILLGFIQMGKDMGQGDASNLQQKLSFEGTNLDVGNIVLALYSGLFAYG----------------G 261

  Fly   256 FDCIATTGEEVRNPRKNIPKSILLSLLIIFLCYFGVSTVLTLMLPYYIQDVNAPL-------PYA 313
            ::.:....||:.||.:|:|.:|::||.|:.|.|     |||.:..:.....|..|       .:.
Mouse   262 WNYLNFVTEEMINPYRNLPLAIIISLPIVTLVY-----VLTNLAYFTTLSTNQMLTSEAVAVDFG 321

  Fly   314 FEYVGWPVAMWIVTVGGLVGL--LASLFGALFPLPRVMYSMAQDGLLFKFLGKVSPRFRVPVTGS 376
            ..::|  |..||:.|  .|||  ..|:.|:||...|:.:..:::|.|...|..:.|:...||...
Mouse   322 NYHLG--VMSWIIPV--FVGLSCFGSVNGSLFTSSRLFFVGSREGHLPSVLSMIHPQLLTPVPSL 382

  Fly   377 IVAALFTAAIAGLFDLSQLVSLLSIGTLLAYSVVAISIMLLRYMDYCEVDENPG-QREVRASETT 440
            :...:.|...|...|:..:::..|....|..::..|.:|.||:       :.|. :|.::.:
Mouse   383 VFTCIMTLMYAFSRDIFSIINFFSFFNWLCVALAIIGMMWLRF-------KKPELERPIKVN--- 437

  Fly   441 SLTSSSERFTFGSVCTQLFNVHRVQEPNAISSRIVGVLSTLFCL--------ISLGIGVLIMQAH 497
                                         ::..:..:|:.||.:        :..|||..|:.:.
Mouse   438 -----------------------------LALPVFFILACLFLIAVSFWKTPMECGIGFAIILSG 473

  Fly   498 LLI-------ASKEVWALTLLIVLVVLMLLVIC--LICLQPRE 531
            |.:       .:|..|     |:..:..:.|:|  |:.:.|:|
Mouse   474 LPVYFFGVWWKNKPKW-----ILQAIFSVTVLCQKLMQVVPQE 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7255	NP_001034016.1	2A0303	9..581	CDD:273330	129/563 (23%)
CG7255	NP_001034016.1	AA_permease_C	537..580	CDD:290617
Slc7a5	NP_035534.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..43		7/16 (44%)
Slc7a5	NP_035534.2	2A0308	35..511	CDD:273332	124/552 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847642
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.930