DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7255 and Slc7a12

DIOPT Version :9

Sequence 1:	NP_001034016.1	Gene:	CG7255 / 39662	FlyBaseID:	FBgn0036493	Length:	1063	Species:	Drosophila melanogaster
Sequence 2:	NP_543128.1	Gene:	Slc7a12 / 140918	MGIID:	2156159	Length:	465	Species:	Mus musculus

Alignment Length:	492	Identity:	105/492 - (21%)
Similarity:	196/492 - (39%)	Gaps:	79/492 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 KLNRVLGLWDLTALGVGSTLGAGVYVLAGQIAKDQAGPSVMISFAIAA---LASLLAGVCYAEFG 88
            :|.|.||::.::.:...:|||.|::|....:.| .:..::.:|.:|.|   |.|:::.:|.||..
Mouse     2 QLLRALGVFHVSMILFSATLGTGIFVTPKAVLK-YSSLNIPVSLSIWAGCGLLSIMSALCNAEIA 65

  Fly    89 ARVPKAGSAYVYSYVCIGEFVAFVIGWNLILEYVIGTASVCRGISLYLDSLLNDTLKYTFAEVAP 153
            ...|.:|::|.:....:|..|||:..|..:..:.:|..:.|   .|...|::........|...|
Mouse    66 TTYPLSGASYYFLKRTLGSSVAFLSLWIKLFAHFLGIGAQC---LLIATSVIQCFYSGCPAPELP 127

  Fly   154 MNVSFLGSYFDFLAFGLVVVFGVALAFGVETSTMANNFVTCLNIFILGF----VIIAGALKADYS 214
            ...         ||..::..||:..|.|::|....|...:.:.:.:|..    |::....|.:.|
Mouse   128 TKC---------LALAILWSFGIVSARGIKTVAWFNTVSSFIKLSVLCLISLTVLLVNGKKENVS 183

  Fly   215 NW--TVDPSTVSANSTIGSGGFFPFGFEGTLRGAATCFFGFVGFDCIATTGEEVRNPRKNIPKSI 277
            .:  .:|....:|:...          :..|:.:    :.::|...:.....|::.|.:.|||::
Mouse   184 RFENALDAELPNASQIA----------DAILQVS----YSYLGSSVLIVIAGEIKRPTETIPKTL 234

  Fly   278 LLSLLIIFLCYF--GVS--TVLTLMLPYYIQDVNAPLPYAFEYVGW-----PVAMWIVTVGGLVG 333
            :..:.|:.:.|.  .:|  .|||.....:...|.         |.|     |...||.:......
Mouse   235 IYGISIVTVLYLLTNISYLAVLTSQEIIFSDSVG---------VTWMNRVFPSIQWISSFLISAF 290

  Fly   334 LLASLFGALFPLPRVMYSMAQDGLLFKFLGKVSPRFRVPVTGSIVAALFTAAIAGLFDLSQLVSL 398
            ||.|:...:....||.||.:|:|........::......|....:..|.:.||.. ..:..||..
Mouse   291 LLGSVSCGIVSASRVFYSASQEGEFPSIYSMLNDHHSPAVADIQIVILSSVAIIS-SSIIYLVKY 354

  Fly   399 LSIGTLLAYSVVAISIMLLRYMDYCEVDENPGQREVRASETTSLTSSSERFTFGSVCTQLFNVHR 463
            :|:|:.....:..|.::.:||       :||   ::.......|.     |.|||:...||.:..
Mouse   355 VSLGSFCINLLQMIGLLKIRY-------QNP---DIPRPYKVWLP-----FIFGSIALSLFLIFT 404

  Fly   464 --VQEPNAISSRIVGVLSTLFCLISLGIGVLIMQAHL 498
              :|.|   |...|..:..|||    |.....:||:|
Mouse   405 PVIQSP---SIEHVYQVVFLFC----GFLCYWLQANL 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7255	NP_001034016.1	2A0303	9..581	CDD:273330	105/492 (21%)
CG7255	NP_001034016.1	AA_permease_C	537..580	CDD:290617
Slc7a12	NP_543128.1	AA_permease_2	7..412	CDD:290254	94/459 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847674
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930