DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7255 and Slc7a1

DIOPT Version :9

Sequence 1:	NP_001034016.1	Gene:	CG7255 / 39662	FlyBaseID:	FBgn0036493	Length:	1063	Species:	Drosophila melanogaster
Sequence 2:	NP_001288353.1	Gene:	Slc7a1 / 11987	MGIID:	88117	Length:	622	Species:	Mus musculus

Alignment Length:	598	Identity:	269/598 - (44%)
Similarity:	379/598 - (63%)	Gaps:	34/598 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LTRRKNLQADGSEGETKLNRVLGLWDLTALGVGSTLGAGVYVLAGQIAKDQAGPSVMISFAIAAL 75
            :.|||  ..|.|..|::|:|.|..:||.|||||||||||||||||.:|::.|||:::|||.||||
Mouse    13 MLRRK--VVDCSREESRLSRCLNTYDLVALGVGSTLGAGVYVLAGAVARENAGPAIVISFLIAAL 75

  Fly    76 ASLLAGVCYAEFGARVPKAGSAYVYSYVCIGEFVAFVIGWNLILEYVIGTASVCRGISLYLDSLL 140
            ||:|||:||.||||||||.||||:||||.:||..||:.||||||.|:|||:||.|..|...|.|:
Mouse    76 ASVLAGLCYGEFGARVPKTGSAYLYSYVTVGELWAFITGWNLILSYIIGTSSVARAWSATFDELI 140

  Fly   141 NDTL-KYTFAEVAPMNVSFLGSYFDFLAFGLVVVFGVALAFGVETSTMANNFVTCLNIFILGFVI 204
            ...: :::...:|......|....|..|..::::....|..||:.|.|.|...||:|:.:|.|::
Mouse   141 GKPIGEFSRQHMALNAPGVLAQTPDIFAVIIIIILTGLLTLGVKESAMVNKIFTCINVLVLCFIV 205

  Fly   205 IAGALKADYSNWTVDPSTVSANST-----IGSGGFFPFGFEGTLRGAATCFFGFVGFDCIATTGE 264
            ::|.:|....||.:.....|.|:.     .|.|||.||||.|.|.||||||:.||||||||||||
Mouse   206 VSGFVKGSIKNWQLTEKNFSCNNNDTNVKYGEGGFMPFGFSGVLSGAATCFYAFVGFDCIATTGE 270

  Fly   265 EVRNPRKNIPKSILLSLLIIFLCYFGVSTVLTLMLPYYIQDVNAPLPYAFEYVGWPVAMWIVTVG 329
            ||:||:|.||..|:.||||.|:.|||||..||||:||:..|:::|||.||::.||..|.:.|.:|
Mouse   271 EVKNPQKAIPVGIVASLLICFIAYFGVSAALTLMMPYFCLDIDSPLPGAFKHQGWEEAKYAVAIG 335

  Fly   330 GLVGLLASLFGALFPLPRVMYSMAQDGLLFKFLGKVSPRFRVPVTGSIVAALFTAAIAGLFDLSQ 394
            .|..|..||.|::||:|||:|:||:||||||||.|::.|.:.||..::.:....|.:|.||:|..
Mouse   336 SLCALSTSLLGSMFPMPRVIYAMAEDGLLFKFLAKINNRTKTPVIATVTSGAIAAVMAFLFELKD 400

  Fly   395 LVSLLSIGTLLAYSVVAISIMLLRYM---------------DYCEVDENPGQREVRASET-TSLT 443
            ||.|:|||||||||:||..:::|||.               :...||:|   ..|.|||: |...
Mouse   401 LVDLMSIGTLLAYSLVAACVLVLRYQPEQPNLVYQMARTTEELDRVDQN---ELVSASESQTGFL 462

  Fly   444 SSSERFTFGSVCTQLFNVHRVQEPNAISSRIVGVLSTLFCLISLGIGVLIMQAHLLIASKEVWAL 508
            ..:|:|:..|:.:.. ||    ||:..|..||.:.:.|...:.:.:.::.:.....:|...:||:
Mouse   463 PVAEKFSLKSILSPK-NV----EPSKFSGLIVNISAGLLAALIITVCIVAVLGREALAEGTLWAV 522

  Fly   509 TLLIVLVVLMLLVICLICLQPREARRRLFRVPFVPIVPAISIFINIYLMLQLDTWTWIRFGVWMI 573
            .::...|:|.:||..:|..||....:..|:|||||::|.:|||:|||||:|||..||:||.|||:
Mouse   523 FVMTGSVLLCMLVTGIIWRQPESKTKLSFKVPFVPVLPVLSIFVNIYLMMQLDQGTWVRFAVWML 587

  Fly   574 VGIPVFL--ACWY 584
            :|..::.  ..|:
Mouse   588 IGFTIYFGYGIWH 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7255	NP_001034016.1	2A0303	9..581	CDD:273330	268/593 (45%)
CG7255	NP_001034016.1	AA_permease_C	537..580	CDD:290617	26/42 (62%)
Slc7a1	NP_001288353.1	2A0303	4..603	CDD:273330	269/598 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847699
Domainoid	1	1.000	453	1.000	Domainoid score	I498
eggNOG	1	0.900	-	-		E2759_KOG1286
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D439017at2759
OrthoFinder	1	1.000	-	-		FOG0000131
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100168
Panther	1	1.100	-	-	LDO	PTHR43243
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X81
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.750