DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7255 and slc7a2.1

DIOPT Version :9

Sequence 1:	NP_001034016.1	Gene:	CG7255 / 39662	FlyBaseID:	FBgn0036493	Length:	1063	Species:	Drosophila melanogaster
Sequence 2:	XP_004911248.1	Gene:	slc7a2.1 / 100485546	XenbaseID:	XB-GENE-994549	Length:	657	Species:	Xenopus tropicalis

Alignment Length:	618	Identity:	282/618 - (45%)
Similarity:	394/618 - (63%)	Gaps:	35/618 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 KVLTRRKNLQADGSEGETKLNRVLGLWDLTALGVGSTLGAGVYVLAGQIAKDQAGPSVMISFAIA 73
            :.:.|||.:..|..| ::||.|.|...||.|||||||||||||||||::||..:|||:::||.||
Frog    12 RCILRRKIVTLDSLE-DSKLCRCLSTLDLVALGVGSTLGAGVYVLAGEVAKANSGPSIVVSFLIA 75

  Fly    74 ALASLLAGVCYAEFGARVPKAGSAYVYSYVCIGEFVAFVIGWNLILEYVIGTASVCRGISLYLDS 138
            ||||::||:|||||||||||.||||:|:||.:||..||:.||||||.|||||:||.|..|...|.
Frog    76 ALASVMAGLCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLILSYVIGTSSVARAWSGTFDE 140

  Fly   139 LLNDTLKYTFAEVAPMNVSFLGSYFDFLAFGLVVVFGVALAFGVETSTMANNFVTCLNIFILGFV 203
            ||...:...|:....||...|..|.|..|..|:::....|:|||:.|...|...|.:|:.:|.||
Frog   141 LLGKRIGQFFSTYFRMNSPGLAEYPDIFAVFLILLLSGLLSFGVKESAWVNKVFTAVNVLVLLFV 205

  Fly   204 IIAGALKADYSNWTV-----------DPSTVS---ANSTIGSGGFFPFGFEGTLRGAATCFFGFV 254
            :|||.:|.|..||.:           |.::||   ..|..|:|||.|:|..|.|.||||||:.||
Frog   206 MIAGFVKGDLQNWKITESFLQNISATDGNSVSYDNVTSLYGAGGFMPYGLTGMLAGAATCFYAFV 270

  Fly   255 GFDCIATTGEEVRNPRKNIPKSILLSLLIIFLCYFGVSTVLTLMLPYYIQDVNAPLPYAFEYVGW 319
            |||||||||||||||::.||..|:.||||.|:.|||||..||||:||:..|..:|||.|||||||
Frog   271 GFDCIATTGEEVRNPQRAIPIGIVASLLICFMAYFGVSAALTLMMPYFKLDEKSPLPVAFEYVGW 335

  Fly   320 PVAMWIVTVGGLVGLLASLFGALFPLPRVMYSMAQDGLLFKFLGKVSPRFRVPVTGSIVAALFTA 384
            ..|.::|.||.|..|..||.|::||:|||:|:||:||||||.|.|:|||.:.||..::.:....|
Frog   336 GPAKYVVAVGSLCALSTSLLGSIFPMPRVIYAMAEDGLLFKSLAKISPRTKTPVIATLSSGAVAA 400

  Fly   385 AIAGLFDLSQLVSLLSIGTLLAYSVVAISIMLLRY---MDYCEVDENPGQRE-VRASETTSLTSS 445
            .:|.||||..||.::|||||||||:||..:::|||   :.| |:.:...::| :.:||..|:.:.
Frog   401 VMAFLFDLKALVDMMSIGTLLAYSLVAACVLILRYQPGLGY-EIPKGNAEKEMLSSSERESMMNE 464

  Fly   446 SERFTFGSVCTQLFNVHRVQEPNAIS--------SRIVGVLSTLFCLISLGIGVLIMQAHLLIAS 502
            |:   ...:..:..:.||:..|.::.        |.:||:|:.:.|.:|    ||.......||.
Frog   465 SQ---ISILHDKSSSFHRLMNPPSVPTEQSASLVSSLVGLLALIICALS----VLTTYGVQAIAD 522

  Fly   503 KEVWALTLLIVLVVLMLLVICLICLQPREARRRLFRVPFVPIVPAISIFINIYLMLQLDTWTWIR 567
            .|||::.||:|.:||:.|::.:|..||:...:..|.|||:|::|..|:.:|:|||:||...||||
Frog   523 IEVWSVALLVVFIVLICLIVMIIWRQPQNKHKITFMVPFLPVLPVFSVLVNVYLMVQLSGDTWIR 587

  Fly   568 FGVWMIVGIPVFLACWYLYDCKNPAKRNPERWD 600
            |.:||::|..::.|....:..:..:|:..:..|
Frog   588 FSIWMVIGFLIYFAYGIRHSVEGKSKKVEDEED 620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7255	NP_001034016.1	2A0303	9..581	CDD:273330	279/597 (47%)
CG7255	NP_001034016.1	AA_permease_C	537..580	CDD:290617	21/42 (50%)
slc7a2.1	XP_004911248.1	2A0303	7..609	CDD:273330	280/605 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H20659
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D421901at33208
OrthoFinder	1	1.000	-	-		FOG0000131
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43243
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X81
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.110