DRSC/TRiP Functional Genomics Resources

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Protein Alignment Best3 and BEST1

DIOPT Version :10

Sequence 1:NP_730039.1 Gene:Best3 / 39661 FlyBaseID:FBgn0036492 Length:535 Species:Drosophila melanogaster
Sequence 2:NP_001427500.1 Gene:BEST1 / 7439 HGNCID:12703 Length:664 Species:Homo sapiens


Alignment Length:434 Identity:178/434 - (41%)
Similarity:264/434 - (60%) Gaps:36/434 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MTVSYTAEVATCSHFGCFWKLLMRWRASIYKIIWVDLLAFLSCFYFMAVIYRYALRDVDKPVFED 65
            ||::||::||. :..|.|.:||:.||.||||:::.:.|.||.|:|.:..|||.||.:..:.:||.
Human     1 MTITYTSQVAN-ARLGSFSRLLLCWRGSIYKLLYGEFLIFLLCYYIIRFIYRLALTEEQQLMFEK 64

  Fly    66 IVMYCHSYSNLIPLSFVLGFYVGIIIERWWNQYITVPWPDPLAVYVSALVRGQDEHGRLMRRTIM 130
            :.:||.||..|||:||||||||.:::.||||||..:||||.|...||..|.|:||.|||:|||::
Human    65 LTLYCDSYIQLIPISFVLGFYVTLVVTRWWNQYENLPWPDRLMSLVSGFVEGKDEQGRLLRRTLI 129

  Fly   131 RYVCLALTMVLSMISPVIKRRFPTYDQLIEVGLLNANEANIMKAMDVKFPKHPKYWMPIVWAASI 195
            ||..|...::|..:|..:.:|||:...|::.|.:...|...::.:.:   .|..:|:|.||.|::
Human   130 RYANLGNVLILRSVSTAVYKRFPSAQHLVQAGFMTPAEHKQLEKLSL---PHNMFWVPWVWFANL 191

  Fly   196 VTRARKEGRIWDDFSLKSMIDELNKFRAGCNMLIHYDTISVPLVYTQVVTLAVYSYFVASIFGHQ 260
            ..:|...|||.|...|:|:::|:|..|..|..|..||.||:|||||||||:||||:|:..:.|.|
Human   192 SMKAWLGGRIRDPILLQSLLNEMNTLRTQCGHLYAYDWISIPLVYTQVVTVAVYSFFLTCLVGRQ 256

  Fly   261 WIDRDIKHYNNIVSYYFPLFSTLEFFFFMGWLKVAETLICPFGDDDDDFELNWLIDRNLQVSYLI 325
            :::....:..:.:....|:|:.|:|||::|||||||.||.|||:||||||.||::|||||||.|.
Human   257 FLNPAKAYPGHELDLVVPVFTFLQFFFYVGWLKVAEQLINPFGEDDDDFETNWIVDRNLQVSLLA 321

  Fly   326 VDEMHNDHPQLVRDQYWDEVFPAELPYAVESDRAEHPEASTARLGIPKVVPVTMTKSEVSLENDF 390
            |||||.|.|::..|.||::..| :.||...|  |:...||.  :|         :...:||..:.
Human   322 VDEMHQDLPRMEPDMYWNKPEP-QPPYTAAS--AQFRRASF--MG---------STFNISLNKEE 372

  Fly   391 TEF----DDEDEYNPEVTIRF--------------ARREFSWSK 416
            .||    :||::.:..:..||              :|.:..|.|
Human   373 MEFQPNQEDEEDAHAGIIGRFLGLQSHDHHPPRANSRTKLLWPK 416

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Best3NP_730039.1 Bestrophin 8..317 CDD:460047 137/308 (44%)
BEST1NP_001427500.1 Auto-inhibitory segment. /evidence=ECO:0000269|PubMed:35789156 346..379 11/45 (24%)

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