Protein Alignment Best3 and Best4

DIOPT Version :10

• Sequence 1: NP_730039.1
• Gene: Best3 / 39661
• FlyBaseID: FBgn0036492
• Length: 535
• Species: Drosophila melanogaster
• Sequence 2: XP_001066317.1
• Gene: Best4 / 689103
• RGDID: 1596200
• Length: 454
• Species: Rattus norvegicus
• Alignment Length: 475
• Identity: 193/475 - (40%)
• Similarity: 278/475 - (58%)
• Gaps: 56/475 - (11%)

  Fly     1 MTVSYTAEVATCSHFGCFWKLLMRWRASIYKIIWVDLLAFLSCFYFMAVIYRYALRDVDKPVFED 65
            ||||||.:||. :.||.|..||.|||.||||:::.:.|.|.:.:..:.:.||..|....|.::..
  Rat     1 MTVSYTLKVAE-ARFGAFSGLLFRWRGSIYKLLYREFLLFCALYATLNITYRLLLTQEQKRIYAQ 64

  Fly    66 IVMYCHSYSNLIPLSFVLGFYVGIIIERWWNQYITVPWPDPLAVYVSALVRGQDEHGRLMRRTIM 130
            :..||:..::||||||||||||.:::.|||:||.::|.||.|...:||.|.|.|:.|||:|||::
  Rat    65 VARYCNRSADLIPLSFVLGFYVTLVVNRWWSQYTSIPLPDQLMCVISASVHGVDQSGRLLRRTLI 129

  Fly   131 RYVCLALTMVLSMISPVIKRRFPTYDQLIEVGLLNANEANIMKAMDVKFPKHPKYWMPIVWAASI 195
            ||..||..:||..:|..:.:||||.:.:::.|.::..|....:::...|   .|||:|.||..::
  Rat   130 RYANLASVLVLRSVSTRVLKRFPTMEHVVDAGFMSQEERKKFESLKSDF---NKYWVPCVWFTNL 191

  Fly   196 VTRARKEGRIWDDFSLKSMIDELNKFRAGCNMLIHYDTISVPLVYTQVVTLAVYSYFVASIFGHQ 260
            ..:||::|||.||.:|..:::||||:||.|.||.|||.||:|||||||||:||||:|..|:.|.|
  Rat   192 AAQARRDGRIRDDIALCLILEELNKYRAKCGMLFHYDWISIPLVYTQVVTIAVYSFFTLSLIGRQ 256

  Fly   261 WIDRDIKHYNNIVSY---YFPLFSTLEFFFFMGWLKVAETLICPFGDDDDDFELNWLIDRNLQVS 322
            :::.| |..:....|   :.||.:.|:|||:.|||||||.||.|||:||||||.|.|||||.|||
  Rat   257 FVESD-KESSPAPWYLDMFVPLTTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNQLIDRNFQVS 320

  Fly   323 YLIVDEMHNDHPQLVRDQYWDEVFPAELPY----AVESDR------------AEHPE-----AST 366
            .|.||:|:.:.|...:|.||||..| :.||    |.||.|            ::.||     .::
  Rat   321 LLSVDDMYQNLPPTEQDLYWDEARP-QPPYTVATAAESQRPSFMGSTFNLRMSDDPEQCLQVEAS 384

  Fly   367 ARLGIPKVVPVTMTKSEVSLENDFTEFDDEDEYNPEVTIRFARREFSWSKSSVSVSYSY------ 425
            .|..:|  .|||.| |:..|...|                .|.|..|.:.|..::..|:
  Rat   385 RRFDLP--APVTQT-SQTPLLGRF----------------LAARAPSPAVSLQNLRTSHLLHLRP 430

  Fly   426 -DNQSIDTLDEKVDEENEGD 444
             ..::...::|.|||.:|.:
  Rat   431 GGEEAEGRIEEAVDEGSENE 450

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Best3	NP_730039.1	Bestrophin	8..317	CDD:460047	143/311 (46%)
Best4	XP_001066317.1	Bestrophin	8..315	CDD:460047	143/311 (46%)