DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Best4 and best4

DIOPT Version :9

Sequence 1:	NP_001097609.1	Gene:	Best4 / 39660	FlyBaseID:	FBgn0036491	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	XP_692160.4	Gene:	best4 / 563711	ZFINID:	ZDB-GENE-070912-6	Length:	515	Species:	Danio rerio

Alignment Length:	456	Identity:	181/456 - (39%)
Similarity:	268/456 - (58%)	Gaps:	37/456 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTVTYTSRVSTSSVLSNFLGLLVRWRGSIYKLIWLDLIVFFGLYCLLAITYRLLVNEEGKRFFEA 65
            |||:||.:|:.:. ...|..||.||:||||||::.:.:||..||..::|.||.::|...:..|..
Zfish    68 MTVSYTLKVANAK-FGGFSKLLFRWKGSIYKLLYREFLVFCLLYTFISILYRCVLNNNQQEIFAR 131

  Fly    66 IMSYCEKNGSLIPLSFVLGFFVRIVMNRWWDQYTTIPWPDGIAILISTSIHGSDDRARVMRRTIL 130
            :..:|.|...|||:||||||:|.....|||.|||:.|.||.:.:::|.::||:|:|.|::|||::
Zfish   132 LARHCNKFAKLIPMSFVLGFYVTQAFQRWWGQYTSFPLPDNLMMVVSGNVHGTDERGRLLRRTLM 196

  Fly   131 RYVCLCQVIVFTMISPRVKRRFPTYTQIIEAGFLLENEKKIIEAMDQAFPSYPKHWMPIVWAASI 195
            ||..|..|::...||.||::||.|...|:||||:..:|   :..::..:..:.|:|||:.|.|::
Zfish   197 RYANLSSVLILRSISTRVRKRFTTLEDIVEAGFMTTDE---LRKLNHLYSDFNKYWMPLAWFANL 258

  Fly   196 VMRARRENKIRDDYAVKTIIDELNQLRGNCGFLLYYDWISVPLVYTQVVTVATYSFFLFSVLGQQ 260
            ..:||:|.:::||.|::.::||||..|..|..|.:|||||:|||||||||||.||||.||::|:|
Zfish   259 ASQARKEGRVKDDIALRLLMDELNNYRSKCSMLFHYDWISIPLVYTQVVTVAVYSFFTFSLIGRQ 323

  Fly   261 WNESHSDEDGTRIRRWFPILTVLQFFFYMGWLKVAETLINPFGEDDDDFELNWIIDRNLTVSYCI 325
            :.:..|.|:  .:..:.||.|:|:||||.|||||.|.:||||||||||||.|.:||||:.||...
Zfish   324 FVKPASSEE--HLDLYIPIFTLLEFFFYAGWLKVGELIINPFGEDDDDFETNQLIDRNIQVSMLA 386

  Fly   326 VDEMHQEHPELVKDQYWEEVFPNEIPYAQPKMRQNPPAASTAYMESQSKLQKRHESAMSTLSTRS 390
            ||:|||..|.|.||:||.:..|:   |....|:       ..:|.|...::...:.....:||..
Zfish   387 VDDMHQNLPPLEKDKYWVDKGPS---YPSASMK-------PVFMGSTHDMRILEDDLEECVSTPK 441

  Fly   391 RNNFRQNFLGRPSATGSYSDSIQM---------EDGPSRVTFSENQFDLPHDEANSS-HKPSQST 445
            ......|.............|:|.         ||..|::           :.:||| |.|...|
Zfish   442 TQMLAINVWPTTHKVKKSKRSLQQLCICCRAEGEDDCSKL-----------EPSNSSVHSPQHKT 495

  Fly   446 I 446
            :
Zfish   496 V 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Best4	NP_001097609.1	Bestrophin	8..319	CDD:279411	143/310 (46%)
best4	XP_692160.4	Bestrophin	75..380	CDD:279411	143/310 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	334	1.000	Domainoid score	I1102
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H129743
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D145964at33208
OrthoFinder	1	1.000	-	-		FOG0001515
OrthoInspector	1	1.000	-	-		mtm6580
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10736
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X320
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	8.020