DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Best4 and BEST2

DIOPT Version :9

Sequence 1:	NP_001097609.1	Gene:	Best4 / 39660	FlyBaseID:	FBgn0036491	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_060152.2	Gene:	BEST2 / 54831	HGNCID:	17107	Length:	509	Species:	Homo sapiens

Alignment Length:	379	Identity:	180/379 - (47%)
Similarity:	251/379 - (66%)	Gaps:	21/379 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTVTYTSRVSTSSVLSNFLGLLVRWRGSIYKLIWLDLIVFFGLYCLLAITYRLLVNEEGKRFFEA 65
            ||||||:||:.:. ...|..||:.||||||||:|.:|:.|.|.|..|:..||.::.|..||:||.
Human     1 MTVTYTARVANAR-FGGFSQLLLLWRGSIYKLLWRELLCFLGFYMALSAAYRFVLTEGQKRYFEK 64

  Fly    66 IMSYCEKNGSLIPLSFVLGFFVRIVMNRWWDQYTTIPWPDGIAILISTSIHGSDDRARVMRRTIL 130
            ::.||::..||||:||||||:|.:|:||||.||..:|.||.:..:::.::||.|||.|:.|||::
Human    65 LVIYCDQYASLIPVSFVLGFYVTLVVNRWWSQYLCMPLPDALMCVVAGTVHGRDDRGRLYRRTLM 129

  Fly   131 RYVCLCQVIVFTMISPRVKRRFPTYTQIIEAGFLLENEKKIIEAMDQAFPSYPKHWMPIVWAASI 195
            ||..|..|::...:|..|.:||||...::||||:...|:|..|.::.   ||.|:|:|.||.:::
Human   130 RYAGLSAVLILRSVSTAVFKRFPTIDHVVEAGFMTREERKKFENLNS---SYNKYWVPCVWFSNL 191

  Fly   196 VMRARRENKIRDDYAVKTIIDELNQLRGNCGFLLYYDWISVPLVYTQVVTVATYSFFLFSVLGQQ 260
            ..:||||.:|||:.|:|.:::|||..||.||.|.:|||||||||||||||:|.||:||..::|:|
Human   192 AAQARREGRIRDNSALKLLLEELNVFRGKCGMLFHYDWISVPLVYTQVVTIALYSYFLACLIGRQ 256

  Fly   261 W---NESHSDEDGTRIRRWFPILTVLQFFFYMGWLKVAETLINPFGEDDDDFELNWIIDRNLTVS 322
            :   .:.:.|.|   :....||.|:||||||.|||||||.|||||||||||||.|::||||..||
Human   257 FLDPAQGYKDHD---LDLCVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNFLIDRNFQVS 318

  Fly   323 YCIVDEMHQEHPELVKDQYWEEVFPNEIPYAQPKMRQNPPAASTAYMESQSKLQ 376
            ...||||:.:...|.||.||:.        |:.:.   |..|:|.:...|...|
Human   319 MLAVDEMYDDLAVLEKDLYWDA--------AEARA---PYTAATVFQLRQPSFQ 361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Best4	NP_001097609.1	Bestrophin	8..319	CDD:279411	156/313 (50%)
BEST2	NP_060152.2	Bestrophin	8..314	CDD:279411	155/312 (50%)
BEST2	NP_060152.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	454..509
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155279
Domainoid	1	1.000	355	1.000	Domainoid score	I996
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	396	1.000	Inparanoid score	I1965
Isobase	1	0.950	-	0	Normalized mean entropy	S3982
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D145964at33208
OrthoFinder	1	1.000	-	-		FOG0001515
OrthoInspector	1	1.000	-	-		mtm8455
orthoMCL	1	0.900	-	-		OOG6_101870
Panther	1	1.100	-	-	O	PTHR10736
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2974
SonicParanoid	1	1.000	-	-		X320
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.880