DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Best4 and Best2

DIOPT Version :9

Sequence 1:	NP_001097609.1	Gene:	Best4 / 39660	FlyBaseID:	FBgn0036491	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001123666.1	Gene:	Best2 / 212989	MGIID:	2387588	Length:	508	Species:	Mus musculus

Alignment Length:	376	Identity:	180/376 - (47%)
Similarity:	252/376 - (67%)	Gaps:	15/376 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTVTYTSRVSTSSVLSNFLGLLVRWRGSIYKLIWLDLIVFFGLYCLLAITYRLLVNEEGKRFFEA 65
            ||||||:||:.:. ...|..||:.||||||||:|.:|:.|.|||..|:..||.|:.||.||:||.
Mouse     1 MTVTYTARVANAR-FGGFSQLLLLWRGSIYKLLWRELLCFLGLYMALSAAYRFLLAEEQKRYFEK 64

  Fly    66 IMSYCEKNGSLIPLSFVLGFFVRIVMNRWWDQYTTIPWPDGIAILISTSIHGSDDRARVMRRTIL 130
            ::.||::..||||:||||||:|.:|::|||:||..:|.||.:..:::.::||.|||.|:.|||::
Mouse    65 LVIYCDQYASLIPVSFVLGFYVTLVVHRWWNQYLCMPLPDALMCIVAGTVHGRDDRGRLYRRTLM 129

  Fly   131 RYVCLCQVIVFTMISPRVKRRFPTYTQIIEAGFLLENEKKIIEAMDQAFPSYPKHWMPIVWAASI 195
            ||..|..|::...:|..|.:||||...::||||:...|:|..|.::.   ||.|:|:|.||.:|:
Mouse   130 RYAGLSAVLILRSVSTAVFKRFPTIDHVVEAGFMTREERKKFENLNS---SYNKYWVPCVWFSSL 191

  Fly   196 VMRARRENKIRDDYAVKTIIDELNQLRGNCGFLLYYDWISVPLVYTQVVTVATYSFFLFSVLGQQ 260
            ..:||||.:|||:.|:|.:::|||..|..||.|.:|||||:|||||||||:|.||:||..::|:|
Mouse   192 AAQARREGRIRDNSALKLLLEELNVFRSKCGMLFHYDWISIPLVYTQVVTIAVYSYFLACLIGRQ 256

  Fly   261 WNESHSDEDGTRIRRWFPILTVLQFFFYMGWLKVAETLINPFGEDDDDFELNWIIDRNLTVSYCI 325
            :.:.........:....||.|:||||||.|||||||.|||||||||||||.|::||||..||...
Mouse   257 FLDPAQGYKDHTLDLCVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNFLIDRNFQVSMLA 321

  Fly   326 VDEMHQEHPELVKDQYWEEVFPNEIPYAQPKMRQNPPAASTAYMESQSKLQ 376
            ||||:.:...|.||.||:.        |:.:.   |..|:||::..|...|
Mouse   322 VDEMYDDLAMLEKDLYWDA--------AEARA---PYTAATAFLLQQPSFQ 361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Best4	NP_001097609.1	Bestrophin	8..319	CDD:279411	155/310 (50%)
Best2	NP_001123666.1	Bestrophin	8..314	CDD:376448	154/309 (50%)
Best2	NP_001123666.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	455..508
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845751
Domainoid	1	1.000	355	1.000	Domainoid score	I981
eggNOG	1	0.900	-	-		E1_KOG3547
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	396	1.000	Inparanoid score	I1945
Isobase	1	0.950	-	0	Normalized mean entropy	S3982
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001515
OrthoInspector	1	1.000	-	-		mtm8695
orthoMCL	1	0.900	-	-		OOG6_101870
Panther	1	1.100	-	-	O	PTHR10736
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2974
SonicParanoid	1	1.000	-	-		X320
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.730