Protein Alignment Best4 and best-20

DIOPT Version :9

• Sequence 1: NP_001097609.1
• Gene: Best4 / 39660
• FlyBaseID: FBgn0036491
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_500411.3
• Gene: best-20 / 189623
• WormBaseID: WBGene00021368
• Length: 486
• Species: Caenorhabditis elegans
• Alignment Length: 533
• Identity: 169/533 - (31%)
• Similarity: 262/533 - (49%)
• Gaps: 86/533 - (16%)

  Fly     1 MTVTYTSRVSTSSVLSNFLGLLVRWRGSIYKLIWLDLIVFFGLYCLLAITY-RLLVNEEGKRFFE 64
            |||:|.|.||:.| .:|||.||:||:|||:|.:..:|:::...|.|:|:.| ::|...:....|.
 Worm     1 MTVSYNSDVSSVS-STNFLRLLLRWKGSIWKSVSSELMMWCFSYFLIALLYHKVLFPNDYYDSFN 64

  Fly    65 AIMSYCEKN-GSLIPLSFVLGFFVRIVMNRWWDQYTTIPWPDGIAILISTSIHGSDDRARVMRRT 128
            .:..||.|. .:.|||:|:|.|||.|::.||...:|.:.|.:..|:.::..|....|.||::||.
 Worm    65 DVAFYCGKELHNYIPLTFMLAFFVSIIVERWRTTFTNMGWIESSALTVNAIIVSKCDEARLIRRN 129

  Fly   129 ILRYVCLCQVIVFTMISPRVKRRFPTYTQIIEAGFLLENEKKIIEAMDQAFPSYPKHWMPIVWAA 193
            |:||:.|.|::.|..||.||:||||....|.:||||.:||::::|.:|.|   |.|:|:||.||.
 Worm   130 IIRYLVLAQILTFRDISIRVRRRFPNIDSIKKAGFLTDNEEELLEGIDLA---YNKYWVPINWAI 191

  Fly   194 SIVMRARRENKIRDDYAVKTIIDELNQLRGNCGFLLYYDWISVPLVYTQVVTVATYSFFLFSVLG 258
            |:..:|..:..:.....:.::|.|:...|.....:..:||..:|:.|.|||..|...:|||.::.
 Worm   192 SLSNQANSKGYVISAPGMVSLIQEIKTFRNGLATICNFDWCPIPIAYPQVVFFAVRIYFLFCLIT 256

  Fly   259 QQWNESHSDE-DGTR--IRRWFPILTVLQFFFYMGWLKVAETLINPFGEDDDDFELNWIIDRNLT 320
            :|:....:.| :..:  ||   |.:|:::|...:||:||||.|:||.||||||||.|::||:|:.
 Worm   257 RQYIRVPNKELEPVQMFIR---PFITIIEFICIVGWMKVAEALLNPLGEDDDDFESNFLIDKNIF 318

  Fly   321 VSYCIVDEMHQEHPELVKDQYWEEVFPNEIPYAQPKMRQNPPAASTAYMESQSKLQKRHESAMST 385
            ....|||:. .|.|.|.:|.:                  :.|.|...|.|
 Worm   319 TGMRIVDQF-DEAPPLFEDTF------------------SDPGAMPIYSE--------------- 349

  Fly   386 LSTRSRNNFRQNFLGRPSATGSYSDSIQMEDGPSRVTFSENQFDLPHDEANSSHKPSQSTIDFND 450
               .|:.|::...|     .||.|:          ||.:  |||     .|.:..|....:...|
 Worm   350 ---ESQKNYQNGAL-----VGSVSN----------VTLA--QFD-----ENITMVPVAPRLSIGD 389

  Fly   451 LIEQRRRERRERIRHRFLDMQSTHLRHDTSGAPYTITVLRPPSDETLSESQEAGD-------RAQ 508
            :    ....|..||.||....|.:.....|...:. .|||.|||   .||.:|.:       ::.
 Worm   390 I----NAHDRSSIRRRFKSGSSQNCSRANSFREHP-KVLRQPSD---GESNDAYELDYETVIKSV 446

  Fly   509 QDPSGSKEPPPNK 521
            .|...|....|.|
 Worm   447 DDLVASSPTKPGK 459

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Best4	NP_001097609.1	Bestrophin	8..319	CDD:279411	118/315 (37%)
best-20	NP_500411.3	Bestrophin	8..317	CDD:279411	118/315 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3547
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28981
OrthoDB	1	1.010	-	-		D145964at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101870
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.730