Protein Alignment Best4 and best-4

DIOPT Version :9

• Sequence 1: NP_001097609.1
• Gene: Best4 / 39660
• FlyBaseID: FBgn0036491
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_493631.2
• Gene: best-4 / 182063
• WormBaseID: WBGene00015288
• Length: 558
• Species: Caenorhabditis elegans
• Alignment Length: 502
• Identity: 160/502 - (31%)
• Similarity: 276/502 - (54%)
• Gaps: 55/502 - (10%)

  Fly     1 MTVTYTSRVSTSSVLSNFLGLLVRWRGSIYKLIWLDLIVFFGLYCLLAITYRLLVNEEGKRFFEA 65
            |||.|:..|:||.:.:. :.:|:||:||::|.||.:|:::...|.:|::.||:|:|:..:..||.
 Worm     1 MTVAYSLDVATSGLFTQ-IKVLLRWKGSVWKSIWSELLIWLLCYSILSVIYRILLNKAQREVFEQ 64

  Fly    66 IMSYCEKNGSLIPLSFVLGFFVRIVMNRWWDQYTTIPWPDGIAILISTSIHGSDDRARVMRRTIL 130
            :.::.:.....||::|:|||:|.||.|||...:..:.|.|..|:.|:..|.|:.::||::||..:
 Worm    65 LCTFFDTFSVFIPVTFMLGFYVSIVYNRWTKVFDNVGWIDTSALTIAQYIRGTSEKARLIRRNCV 129

  Fly   131 RYVCLCQVIVFTMISPRVKRRFPTYTQIIEAGFLLENEKKIIEAMDQAFPSYPKHWMPIVWAASI 195
            ||:.:.||:||..:||.::|||||...:|.||.|.|:|   :...|.......|:|.||.|..|:
 Worm   130 RYMIVAQVMVFRDVSPAIRRRFPTIKHLIGAGLLTEDE---LTEFDAITSPQSKYWQPIQWLFSL 191

  Fly   196 VMRARRENKIRDDYAVKTIIDELNQLRGNCGFLLYYDWISVPLVYTQVVTVATYSFFLFSVLGQQ 260
            |..|:.|..|.|.|....:||::.:.|.....|:.:|.:.:||||||||.:|..::|:.::.|:|
 Worm   192 VTVAKDEGLIADSYLYVDLIDKMREFRTKILNLVIFDMVPIPLVYTQVVNLAVRTYFVLALFGRQ 256

  Fly   261 WNESHSDEDGT--RIRRWFPILTVLQFFFYMGWLKVAETLINPFGEDDDDFELNWIIDRNLTVSY 323
            :.|::::..|.  :|..:|||:|.||..|.:|||||:|.::||.||||:|||.||||:|||.|.|
 Worm   257 FLENNNNIPGAKWKIDIYFPIMTSLQIVFIVGWLKVSEVMLNPLGEDDEDFETNWIIERNLQVGY 321

  Fly   324 CIVDEMHQEHPELVKDQYWEEVFPNEIPYAQPKMRQNPPAASTAYMESQSKLQKRHE-------- 380
            .:||:.:..:|.|.:|.:||:        ..|:....|.:...|:...|......:|
 Worm   322 AVVDQAYGRYPTLKRDPFWED--------ETPQTMDTPTSTRKAHSHMQGSCINMNEADLDNGLI 378

  Fly   381 ---------------SAMSTLSTRSRNN--------FRQNFLGRPSATGSYSDSIQMEDGPSRVT 422
                           |:.||.:||:::|        ::|   .|...:.:.:...:.|..|.|.:
 Worm   379 SYVRRRSRSFGDDDASSFSTENTRTQSNASMLPRHMWQQ---PRNKISAAIAKFYKSEAEPRRAS 440

  Fly   423 FSENQFDLPHDEANSSHK---PSQST----IDFNDLIEQRRRERRER 462
            ......:|.|...::..:   |.::|    |:...|:::|.|..:::
 Worm   441 VCVAALNLNHRRPSTDLREIEPIENTDDVVINVPALVQERIRIAKQQ 487

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Best4	NP_001097609.1	Bestrophin	8..319	CDD:279411	121/312 (39%)
best-4	NP_493631.2	Bestrophin	8..317	CDD:279411	121/312 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	282	1.000	Domainoid score	I871
eggNOG	1	0.900	-	-		E1_KOG3547
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28981
OrthoDB	1	1.010	-	-		D145964at33208
OrthoFinder	1	1.000	-	-		FOG0001515
OrthoInspector	1	1.000	-	-		mtm4777
orthoMCL	1	0.900	-	-		OOG6_101870
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2974
SonicParanoid	1	1.000	-	-		X320
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.760