Protein Alignment Best4 and best-7

DIOPT Version :9

• Sequence 1: NP_001097609.1
• Gene: Best4 / 39660
• FlyBaseID: FBgn0036491
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_502108.2
• Gene: best-7 / 178030
• WormBaseID: WBGene00007808
• Length: 540
• Species: Caenorhabditis elegans
• Alignment Length: 556
• Identity: 167/556 - (30%)
• Similarity: 274/556 - (49%)
• Gaps: 89/556 - (16%)

  Fly     1 MTVTYTSRVSTSSVLSNFLGLLVRWRGSIYKLIWLDLIVFFGLYCLLAITYRLLVNEEGKRFFEA 65
            ||..|...::||. ....|.|:.:|:||::|.|:|||||:...|..:::.||..::...:..||.
 Worm     1 MTYNYHYDLATSQ-RKVILKLIFKWKGSLWKAIYLDLIVWCFCYAFISVIYRYALDRSQQDTFER 64

  Fly    66 IMSYCEKNGSLIPLSFVLGFFVRIVMNRWWDQYTTIPWPDGIAILISTSIHGSDDRARVMRRTIL 130
            .|.:|.:....||::|:|||||..|:|||..|:..:...|.||:..|..:.|:|:|.|::||:|:
 Worm    65 FMQFCNRRLDYIPINFMLGFFVTTVINRWMTQFANLGMIDNIALFTSMYLSGNDERGRILRRSIV 129

  Fly   131 RYVCLCQVIVFTMISPRVKRRFPTYTQIIEAGFLLENEKKIIEAMDQAFPSYPKHWMPIVWAASI 195
            |...:.|.:||..|...|::||||...::.||.:..:|.|....::.   .|.|:|:...|..::
 Worm   130 RMCVMSQTMVFRDIHIGVRKRFPTLETMVAAGIMTSSELKKYNEVES---RYAKYWLGFNWTFNL 191

  Fly   196 VMRARRENKIRDDYAVKTIIDELNQLRGNCGFLLYYDWISVPLVYTQVVTVATYSFFLFSVLGQQ 260
            :..||||.:|...|....|.:|:...|.....:..|||:.:||:|.|:|.:|.:.::|..::.:|
 Worm   192 LNEARREGRIESAYTQNAIAEEIRTFRSGLSLIWTYDWVPIPLMYPQLVFMAIHCYYLVCLVSRQ 256

  Fly   261 WNESHSDEDGTRIRRWFPILTVLQFFFYMGWLKVAETLINPFGEDDDDFELNWIIDRNLTVSYCI 325
            :..:....:.|.|....|.:|:::|.|||||||||..|:||||||:|||:.|::|||||||:..|
 Worm   257 FVINSDAVNTTEIDLGVPFMTIIEFIFYMGWLKVAMDLLNPFGEDEDDFDCNFLIDRNLTVAMGI 321

  Fly   326 VDEMHQEHPELVKDQYWEEVFPNEIPYAQPKMRQNPPAASTAYMESQSKLQKRHESAMSTLSTRS 390
            ||:.|.:.|.|.||.:|.:                  ..|..|               |:.:.:.
 Worm   322 VDDSHDDGPILEKDMFWND------------------TVSPLY---------------SSAAAQR 353

  Fly   391 RNNFRQNFLGRPSATGSYSDSIQMEDGPSRVTFSENQFDLPH------DE---ANSSHKPSQSTI 446
            ..||   :.|  |||.:   ..|:.|...::|.      :||      |:   ..::..|.||.:
 Worm   354 NVNF---YFG--SATNA---DAQIPDDVRQITM------IPHPLNEKLDQMYGKRTNRPPVQSVV 404

  Fly   447 DFNDLIEQR---RRERRERIRHRFLD-----MQSTHLRHDTSGAPYTITVLRPPSD-ETLSESQ- 501
            :...  :||   ...|::.:..:|.:     .|..|.:..|. .|.:.|..|..:| ||:|..:
 Worm   405 ELKR--DQRFSTGNNRKQTLEAKFSNKLGAMFQKRHSKSLTF-TPESSTKARASTDIETVSTFEN 466

  Fly   502 -------------EAGDRAQQDPSGSKEP---PPNK 521
                         |..:.:|..|..::||   ||.|
 Worm   467 TQKPCYSNPDCIVEVDEESQDIPKVTEEPKQEPPRK 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Best4	NP_001097609.1	Bestrophin	8..319	CDD:279411	111/310 (36%)
best-7	NP_502108.2	Bestrophin	8..315	CDD:279411	111/310 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	282	1.000	Domainoid score	I871
eggNOG	1	0.900	-	-		E1_KOG3547
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	299	1.000	Inparanoid score	I1638
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D145964at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm4777
orthoMCL	1	0.900	-	-		OOG6_101870
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2974
SonicParanoid	1	1.000	-	-		X320
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.800