DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Best4 and best-15

DIOPT Version :9

Sequence 1:	NP_001097609.1	Gene:	Best4 / 39660	FlyBaseID:	FBgn0036491	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_502007.2	Gene:	best-15 / 177975	WormBaseID:	WBGene00011258	Length:	525	Species:	Caenorhabditis elegans

Alignment Length:	532	Identity:	167/532 - (31%)
Similarity:	276/532 - (51%)	Gaps:	44/532 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTVTYTSRVSTSSVLSNFLGLLVRWRGSIYKLIWLDLIVFFGLYCLLAITYR--LLVNEEGKRFF 63
            |||.|...||::|:.| ||.|.:||:|||:|.:..:|.:|...:..::..||  |::.|:.::.:
Worm     1 MTVNYNLDVSSASIFS-FLRLQLRWKGSIWKYLLKELFMFIIAFITVSSVYRSNLIIGEKTRKIW 64

  Fly    64 EAIMSYCEKNGSLIPLSFVLGFFVRIVMNRWWDQYTTIPWPDGIAILISTSIHGSDDRARVMRRT 128
            :...:..::|...|||:|:|||||.|::.||.|.:..:.|.:..||.::..|.|:|||.|::||.
Worm    65 DNFAALFDQNMDFIPLTFMLGFFVTIIVRRWNDIFANLGWVENTAITVANYIRGTDDRTRMIRRN 129

  Fly   129 ILRYVCLCQVIVFTMISPRVKRRFPTYTQIIEAGFLLENEKKIIEAMDQA-FPSYPKHWMPIVWA 192
            ::||:.|.||:||...|.:|::||||...|:.|||:||:||   ||:|.. .....|:::||.|:
Worm   130 VIRYMVLAQVLVFRDCSIQVRKRFPTMESIVSAGFMLEHEK---EALDNVQCGKLQKYFVPIQWS 191

  Fly   193 ASIVMRARRENKIRDDYAVKTIIDELNQLRGNCGFLLYYDWISVPLVYTQVVTVATYSFFLFSVL 257
            ..:::.||.|.||..|..:..|...:.:.|.....|..|||:.:||.|.|||.:|..|:|..:::
Worm   192 TGLLVDARAEGKIAADLLMNEIGKHIIEFRKMLALLSNYDWVPIPLAYPQVVFLAVRSYFFMALI 256

  Fly   258 GQQ--WNESHSDEDGTRIRRWFP-ILTVLQFFFYMGWLKVAETLINPFGEDDDDFELNWIIDRNL 319
            .:|  ..:....|..:.:....| ::::|||.|.:||:||||::|||.||||||||.|:::||||
Worm   257 ARQSVLLDGKEPEQPSILYPTVPFVMSILQFIFVVGWMKVAESMINPLGEDDDDFECNYLLDRNL 321

  Fly   320 TVSYCIVDEMHQEHPELVKDQYW----EEVFPNE---IPYAQPKMRQNPPAASTA----YMESQS 373
            .:..||||:.:...|.:.||.:|    |.::..|   ||       :||...|.|    .::.:.
Worm   322 MIGLCIVDDNYNRTPSVEKDAFWCADVEPLYSVETAMIP-------KNPQIGSAANYDVKVDEEE 379

  Fly   374 KLQKRHESAMSTLSTRSRNNF--RQNF--------LGRPSATGSYSDSIQMEDGPSRVTFSE--- 425
            .:...|...:......|.||.  |:.|        .|..::..|...|:..:....|:...:
Worm   380 VMMMPHMDDVDLFDFESTNNLIPRKTFSVISIQRPFGSRASLASRKRSMMFDQLRGRIAKKQHRS 444

  Fly   426 NQFDLPHDEANSSHKPSQSTIDFNDLIEQRRRERRERIRHRFLDMQSTHLRHDTSGAPYTITVLR 490
            |.|.....:|:..:..||:..:.|....:....:|:....:...|.....:|..|.....|.:
Worm   445 NMFQNSVSQASLHYFESQAPSEINLSTLEMTAPKRKSSTGKLGSMNVAEEQHKLSAEVLPIVI-- 507

  Fly   491 PPSDETLSESQE 502
             ..||..|:..|
Worm   508 -EEDEERSKMLE 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Best4	NP_001097609.1	Bestrophin	8..319	CDD:279411	120/316 (38%)
best-15	NP_502007.2	Bestrophin	8..321	CDD:279411	120/316 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3547
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	299	1.000	Inparanoid score	I1638
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28981
OrthoDB	1	1.010	-	-		D145964at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm4777
orthoMCL	1	0.900	-	-		OOG6_101870
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X320
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.780