Protein Alignment Best4 and best-18

DIOPT Version :9

• Sequence 1: NP_001097609.1
• Gene: Best4 / 39660
• FlyBaseID: FBgn0036491
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_001255067.1
• Gene: best-18 / 176436
• WormBaseID: WBGene00011868
• Length: 456
• Species: Caenorhabditis elegans
• Alignment Length: 474
• Identity: 156/474 - (32%)
• Similarity: 259/474 - (54%)
• Gaps: 36/474 - (7%)

  Fly     1 MTVTYTSRVSTSSVLSNFLGLLVRWRGSIYKLIWLDLIVFFGLYCLLAITYRLLVNEEGKRFFEA 65
            |||:|...|:||...: ||.|:.|||||::..||:...|:.|||.|::..||.:::...::.|..
 Worm     1 MTVSYNQSVATSRPWT-FLALIFRWRGSVWSAIWIQYSVWLGLYFLVSAIYRFILSAYQQQIFVR 64

  Fly    66 IMSYCEKNGSLIPLSFVLGFFVRIVMNRWWDQYTTIPWPDGIAILISTSIHGSDDRARVMRRTIL 130
            ::.|.....|.:||.::||||:..|:.|:|..|..|.:.|.||...:|.|.|..:||:..||.|:
 Worm    65 LVDYVNSRMSYVPLDWMLGFFIAGVLRRFWYLYDIIGFIDNIACSTATYIRGDSERAKQYRRNII 129

  Fly   131 RYVCLCQVIVFTMISPRVKRRFPTYTQIIEAGFLLENEKKIIEAMDQAFPSYPKHWMPIVWAASI 195
            ||..|.||::|..:|.:.::||||...:..|||::.:||...:.:..   :|.|:::|..||.::
 Worm   130 RYCELTQVLIFRDLSMKARKRFPTLDTVAAAGFMMPHEKANFDLIQY---NYNKYFLPFNWAWAL 191

  Fly   196 VMRARRENKIRDDYAVKTIIDELNQLRGNCGFLLYYDWISVPLVYTQVVTVATYSFFLFSVLGQQ 260
            |..||:|..|..||.|..|.:::.:.|....::..|||:.:|::|..:|.:|.:.:|...:|.:|
 Worm   192 VYNARKEGLIEGDYYVTVISEDIKKFRTGLAWVCNYDWVPLPIIYPTIVCLAVHMYFFVGILARQ 256

  Fly   261 WNESHSDEDGTRIRRWFPILTVLQFFFYMGWLKVAETLINPFGEDDDDFELNWIIDRNLTVSYCI 325
            :.:. |:.|...|...||.:|.:||.||||||||.|.|:||:|||.||||.|.:|||||.:...|
 Worm   257 YVKG-SEIDPDMIDLVFPFMTSIQFVFYMGWLKVGEGLLNPWGEDPDDFETNMLIDRNLAMGLKI 320

  Fly   326 VDEMHQEHPELVKDQYWEEVFPNEIP-YAQP---KMRQNPPAASTAYME-----SQSKLQKRHES 381
            |||.:.:.|.|.||.:|::.:   :| |::.   :.|.:....|.|:::     ||.::..|...
 Worm   321 VDEGYDKTPRLEKDAFWDDTW---VPLYSEASAHEKRYHQRQGSLAHIKIGRSVSQVRMVPRDGR 382

  Fly   382 AMSTLSTRSRNNFRQNFLG---RPSAT------GSYSDSIQMEDGPSRVTFSENQFDLPHDEANS 437
            ..|.:..|..|....:.:|   |||:.      .|.|.|::.:..|.....          |..:
 Worm   383 RASIVKERIVNVKPGSGIGDILRPSSLLNLMKHASSSRSLERQRSPGSFRM----------ETLT 437

  Fly   438 SHKPSQSTIDFNDLIEQRR 456
            ...|:.:.|:..|.|::::
 Worm   438 PGSPTNTPIEPIDKIDKKK 456

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Best4	NP_001097609.1	Bestrophin	8..319	CDD:279411	117/310 (38%)
best-18	NP_001255067.1	Bestrophin	9..314	CDD:279411	117/309 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	282	1.000	Domainoid score	I871
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	299	1.000	Inparanoid score	I1638
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28981
OrthoDB	1	1.010	-	-		D145964at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm4777
orthoMCL	1	0.900	-	-		OOG6_101870
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X320
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.880