Protein Alignment Best4 and best-24

DIOPT Version :9

• Sequence 1: NP_001097609.1
• Gene: Best4 / 39660
• FlyBaseID: FBgn0036491
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_498717.1
• Gene: best-24 / 176110
• WormBaseID: WBGene00022797
• Length: 632
• Species: Caenorhabditis elegans
• Alignment Length: 601
• Identity: 185/601 - (30%)
• Similarity: 304/601 - (50%)
• Gaps: 80/601 - (13%)

  Fly     1 MTVTYTSRVSTSSVLSNFLGLLVRWRGSIYKLIWLDLIVFFGLYCLLAITYRLLVNEEGKRFFEA 65
            ||:.|...||||...:.| .||::|||||:|.:.|:|.|:..||.:|::.||..:|...:|.||.
 Worm     1 MTINYNLAVSTSKPWTLF-KLLLKWRGSIWKAVILELAVWLVLYGILSVIYRTALNPGQQRTFER 64

  Fly    66 IMSYCEKNGSLIPLSFVLGFFVRIVMNRWWDQYTTIPWPDGIAILISTSIHGSDDRARVMRRTIL 130
            |:.||:...|.|||:|:|||||..|:|||...|..|.:.|.|.::.:..:.|..::||:.||.|:
 Worm    65 IVQYCDSRLSYIPLNFMLGFFVTAVVNRWTYLYQIIGFIDNIGLMAAEYVRGRTEQARMYRRNIV 129

  Fly   131 RYVCLCQVIVFTMISPRVKRRFPTYTQIIEAGFLLENEKKIIEAMDQAFPSYPKHWMPIVWAASI 195
            ||..|.||:||..||.|.:|||||...::.|||::.:||   :..|:....|.|:|:|..||.|:
 Worm   130 RYCELAQVLVFRDISMRTRRRFPTLDTVVAAGFMMPHEK---DRFDEIQYKYSKYWVPFQWAFSL 191

  Fly   196 VMRARRENKIRDDYAVKTIIDELNQLRGNCGFLLYYDWISVPLVYTQVVTVATYSFFLFSVLGQQ 260
            ...||::..|..||....:.||:.:.|....::..|||:.:|::|.|:|.:|.:::||..:|.:|
 Worm   192 TYEARKKGLIESDYYQVVVQDEIKKFRTGLAWICNYDWVPIPIMYPQLVCLAVHTYFLVCLLARQ 256

  Fly   261 WNESHSDEDGTRIRRWFPILTVLQFFFYMGWLKVAETLINPFGEDDDDFELNWIIDRNLTVSYCI 325
            :..|...::.|.|..:|||::.|||.|||||:||||.::|||||||||||.|.:||||:|:...:
 Worm   257 YVVSEHADNKTEIDLYFPIMSTLQFIFYMGWMKVAEAMLNPFGEDDDDFECNALIDRNITMVLMM 321

  Fly   326 VDEMHQEHPELVKDQYWEE-----------VFPN----------EIPYAQPKMRQNPPAASTAYM 369
            ||:.:...|:|.:|.:|:|           ..||          ::|....:::..|.....:.:
 Worm   322 VDQGYDRAPDLKRDDFWDEEVEPLYSEETAKIPNNPLKGSVSDVKLPEYVHEIKMVPHCDDASPL 386

  Fly   370 ESQSKLQKRHESAMSTLSTRSRNNFR----QNFLGRPSATGSYSDSIQ-------MEDGPSRVTF 423
            ....::::|..|.:....:..:::..    :..||......|:.:.|:       :.|...|.||
 Worm   387 VPGDEMRRRRVSVVPVKPSDQQHHHHGHRTRTSLGNIEMFRSFKNKIERSFSKPHLHDDLGRKTF 451

  Fly   424 SENQFDLPHDE------ANSSHKPSQSTIDF------NDLIEQR-------------RRERRERI 463
            |....:....|      |:.||..:.|..:.      .||..:|             :|......
 Worm   452 SHGMLENMEFEGSNTNIADGSHANNNSFTNSAFVNSGEDLSNKRIDTSSSQPQLATGKRGSEHPF 516

  Fly   464 RHRFLD----------MQSTHLRHDTSGAPYTITVLRPPSDET--------LSESQEAGDRAQQD 510
            :|..||          .|.| :|..:|.....||::...::.|        ..|.::..:..:::
 Worm   517 QHHVLDDVLEDDESDENQLT-IRKKSSVLQPAITLVERFNEATGQLETEVKRDEKKKKEEELREE 580

  Fly   511 PSGSKEPPPNKTEKQD 526
            ....||...||.:|::
 Worm   581 GDNGKEEKDNKEDKKE 596

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Best4	NP_001097609.1	Bestrophin	8..319	CDD:279411	133/310 (43%)
best-24	NP_498717.1	Bestrophin	9..315	CDD:279411	133/309 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159960
Domainoid	1	1.000	282	1.000	Domainoid score	I871
eggNOG	1	0.900	-	-		E1_KOG3547
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	299	1.000	Inparanoid score	I1638
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D145964at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm4777
orthoMCL	1	0.900	-	-		OOG6_101870
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2974
SonicParanoid	1	1.000	-	-		X320
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.730