Protein Alignment Best4 and best-8

DIOPT Version :9

• Sequence 1: NP_001097609.1
• Gene: Best4 / 39660
• FlyBaseID: FBgn0036491
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_493472.1
• Gene: best-8 / 173285
• WormBaseID: WBGene00007988
• Length: 512
• Species: Caenorhabditis elegans
• Alignment Length: 521
• Identity: 167/521 - (32%)
• Similarity: 259/521 - (49%)
• Gaps: 89/521 - (17%)

  Fly     1 MTVTYTSRVSTSSVLSNFLGLLVRWRGSIYKLIWLDLIVFFGLYCLLAITYRLLVNEEGKRFFEA 65
            |||:|...||:.|.. ||..||.|||||::|.||.:|:::...|.|:.:|||:.:..|.|.....
 Worm     1 MTVSYNLDVSSVSFF-NFFKLLFRWRGSVWKSIWSELVLWLLGYYLVMVTYRVALTTEQKAGVRK 64

  Fly    66 IMSYCEKN-GSLIPLSFVLGFFVRIVMNRWWDQYTTIPWPDGIAILISTSIHGSDDRARVMRRTI 129
            .:.:.::| ...:||:|:|.|||.|:::||.:.:..|.:.:..||.|:|.:.|::....:.:|||
 Worm    65 YIDHLDQNLDKCVPLTFMLAFFVTIIVDRWKNMFANIGFIENTAIAIATLVKGTEGDVLLAKRTI 129

  Fly   130 LRYVCLCQVIVFTMISPRVKRRFPTYTQIIEAGFLLENEKKIIEAMDQAFPSYPKHWMPIVWAAS 194
            :||:.|.||:||..||.:|:||||.:..||:||||.::| .||...|....:|   |||:.|:::
 Worm   130 IRYLVLTQVLVFRDISLKVRRRFPNHDAIIKAGFLQDHE-SIILGGDNGRTNY---WMPVNWSSA 190

  Fly   195 IVMRARRENKIRDDYAVKTIIDELNQLRGNCGFLLYYDWISVPLVYTQVVTVATYSFFLFSVLGQ 259
            |:.:...:..|.......::..|:...|.|...|..|||:.:|:.|.|||..|...:|...:..:
 Worm   191 ILQKLFEDGNIPAAPLFNSVWQEVKTFRSNMATLCNYDWVPIPIAYPQVVFFAVRVYFFTCLFTR 255

  Fly   260 QWNESHSD-EDGTRIRRWFPILTVLQFFFYMGWLKVAETLINPFGEDDDDFELNWIIDRNLTVSY 323
            |    |.| ||...|..:||||||.||.|:|||:||||.|:||.||||||||.|::||||:....
 Worm   256 Q----HLDMEDTKTIDYYFPILTVFQFTFFMGWMKVAEALLNPLGEDDDDFECNYLIDRNIATGM 316

  Fly   324 CIVDEMHQEHPELVKDQYWEEVFPNEIPY-----------------------AQP-------KMR 358
            .||:..:.:.||::.|::.:   |:..||                       |:|       |:.
 Worm   317 AIVNSKYSDVPEMLADKFND---PSYAPYYPEKVIDSGADHALVGSAQTVTLAEPNDIIDMMKVD 378

  Fly   359 QNPP-AASTAYMESQSKLQKRHESAMSTLSTRSRNNFRQNFLG--RPSATGSYSDSIQME----- 415
            .|.| ........:.|.:::|..||.      .|.:.....||  :|..|..:|.|:..:
 Worm   379 LNSPIVVGRRNTNNTSTIRRRLSSAF------GRRSHSVQHLGPEKPEPTSPFSQSMAPQRPYGA 437

  Fly   416 ---------DGPSRVTFSENQFDLPHDEANS-------------------SHKPSQSTIDFNDLI 452
                     .|.|.:|   :|..||..|..|                   |.:|:..|:.|:..:
 Worm   438 FELSNGFNLSGLSGIT---SQSHLPKLEEESETTDPLPAQQPVFVLPRTLSEEPTSPTLPFDQTL 499

  Fly   453 E 453
            |
 Worm   500 E 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Best4	NP_001097609.1	Bestrophin	8..319	CDD:279411	125/312 (40%)
best-8	NP_493472.1	Bestrophin	8..312	CDD:279411	125/312 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3547
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28981
OrthoDB	1	1.010	-	-		D145964at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101870
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.730