DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Best4 and AgaP_AGAP011745

DIOPT Version :9

Sequence 1:	NP_001097609.1	Gene:	Best4 / 39660	FlyBaseID:	FBgn0036491	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	XP_320767.3	Gene:	AgaP_AGAP011745 / 1280897	VectorBaseID:	AGAP011745	Length:	686	Species:	Anopheles gambiae

Alignment Length:	570	Identity:	276/570 - (48%)
Similarity:	358/570 - (62%)	Gaps:	63/570 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTVTYTSRVSTSSVLSNFLGLLVRWRGSIYKLIWLDLIVFFGLYCLLAITYRLLVNEEGKRFFEA 65
            ||||||:.|:|......||.||||||||||||:||||..|..||.:|.||||..::|:.||.||.
Mosquito     1 MTVTYTAEVATCRGFGCFLKLLVRWRGSIYKLVWLDLTCFLLLYYVLNITYRFGLSEDQKRIFEE 65

  Fly    66 IMSYCEKNGSLIPLSFVLGFFVRIVMNRWWDQYTTIPWPDGIAILISTSIHGSDDRARVMRRTIL 130
            |:.||....:||||||||||:|.|||.|||:|||:|||||.||:.:|.:|||.|:|.|||||||:
Mosquito    66 IVKYCATYSNLIPLSFVLGFYVTIVMTRWWNQYTSIPWPDPIAVFVSANIHGQDERGRVMRRTIM 130

  Fly   131 RYVCLCQVIVFTMISPRVKRRFPTYTQIIEAGFLLENEKKIIEAMDQAFPSYPKHWMPIVWAASI 195
            ||||||..:|.|.||||||:||||...::|||.|.|||..|:..::|.||.:.|||:||||||||
Mosquito   131 RYVCLCLTMVLTNISPRVKKRFPTIEHLVEAGLLNENEHNIMSHLNQKFPRHSKHWLPIVWAASI 195

  Fly   196 VMRARRENKIRDDYAVKTIIDELNQLRGNCGFLLYYDWISVPLVYTQVVTVATYSFFLFSVLGQQ 260
            |.|||:|.:.|||:|.||||||||:.||.||.|:.||.||||||||||||:|.||:||.||:|||
Mosquito   196 VTRARKEGRCRDDFASKTIIDELNKFRGQCGLLISYDTISVPLVYTQVVTLAVYSYFLTSVMGQQ 260

  Fly   261 WNESHSDEDG--TRIRRWFPILTVLQFFFYMGWLKVAETLINPFGEDDDDFELNWIIDRNLTVSY 323
            |.|:....:|  .:|.::|||.|.||||||||||||||:|||||||||||||:||::||||.|||
Mosquito   261 WVETKELGEGVVNKIDQYFPIFTTLQFFFYMGWLKVAESLINPFGEDDDDFEVNWMVDRNLQVSY 325

  Fly   324 CIVDEMHQEHPELVKDQYWEEVFPNEIPY--AQPKMRQNPPAASTAYMESQSKLQKRHESAMSTL 386
            .||||||.|||||:|||||:|:||.|:|:  |..::|:.||..|||    ...::||....:..:
Mosquito   326 LIVDEMHHEHPELLKDQYWDEIFPTELPHTVASAEIREEPPQPSTA----DIVVKKREAEVIPVV 386

  Fly   387 STRSR---------------NNFRQNFLGRPSATGSYSDSIQMEDGPSRVT---------FSENQ 427
            .|..|               .:.:..:.|..|||...|.:..|    |||.         ||:::
Mosquito   387 PTAVRIDEMMDDNVSGIHFNTSDKPIYRGGSSATSLASVAGTM----SRVNTVTSALKRFFSKDE 447

  Fly   428 FDLPHDEANSSHKPSQSTIDF--------NDLIEQRRRER---RERIRHRFLD-----MQSTHLR 476
            ...|    ||:...:..::.|        |:|...|..:|   ..||..:.::     :..|.::
Mosquito   448 SSRP----NSATPDAAGSVPFKFPGSASSNNLAGGRIPDRAMGSMRITDQVIEEVDEQLTITSMQ 508

  Fly   477 HDTSGAPYTITVLR---PPSDETLSESQEAGDRAQQDPS----GSKEPPP 519
            .:....|...::..   |...|.:...|:|.:|.|...:    .|:..||
Mosquito   509 GNNDSRPTAASLFEHGPPKPSEPVDVPQQAYNRTQSSVAHGFHHSQLTPP 558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Best4	NP_001097609.1	Bestrophin	8..319	CDD:279411	201/312 (64%)
AgaP_AGAP011745	XP_320767.3	Bestrophin	8..321	CDD:279411	201/312 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3547
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D145964at33208
OrthoFinder	1	1.000	-	-		FOG0001515
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10736
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X320
TreeFam	0	0.000	Not matched by this tool.
	6	5.920