DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tak1 and RIPK2

DIOPT Version :9

Sequence 1:NP_524080.1 Gene:Tak1 / 39659 FlyBaseID:FBgn0026323 Length:678 Species:Drosophila melanogaster
Sequence 2:NP_003812.1 Gene:RIPK2 / 8767 HGNCID:10020 Length:540 Species:Homo sapiens


Alignment Length:661 Identity:160/661 - (24%)
Similarity:254/661 - (38%) Gaps:182/661 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    25 VGHGSYGVVCK---AVWRDKLVAVKEF-----FASAEQKDIEKEVKQLSRVKHPNIIALHGISSY 81
            :..|:.|.|..   |.||.: ||||..     ...:|:||:.:|.:.|.:.:...|:.:.||.:.
Human    24 LSRGASGTVSSARHADWRVQ-VAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNE 87

  Fly    82 QQATYLIMEFAEGGSLHNFLHGKVK-PAYSLAHAMSWARQCAEGLAYLHAMTPKPLIHRDVKPLN 145
            .:...::.|:...|||:..||.|.: |..:.........:.|.|:.|||.||| ||:|.|:|..|
Human    88 PEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTP-PLLHHDLKTQN 151

  Fly   146 LLLTNKGRNLKICDFGTVADKSTMMTNNR--------GSAAWMAPEVFE---GSKYTEKCDIFSW 199
            :||.|: .::||.|||....:...::.:|        |:..:|.||.:|   .|:.:.|.||:|:
Human   152 ILLDNE-FHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSY 215

  Fly   200 AIVLWEVLSRKQPFKGIDNAYTIQWKIYKGERP-------PLLTTCPKRIEDLMTACWKTVPEDR 257
            |::.||||||||||:.:.|...|.:.:.:|.||       |.......|:..|:.:.|...|::|
Human   216 AVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDER 280

  Fly   258 PSMQYIVGVMHEIVKDYTGADKALEYTFVNQQIVTKESDGTVAAQPDSLSSQEGELSPSSTQLTP 322
            ||....:..:..:::.:.      |.||:...|..|::      :..|:||              
Human   281 PSFLKCLIELEPVLRTFE------EITFLEAVIQLKKT------KLQSVSS-------------- 319

  Fly   323 TTAANANVNAIAISKTTTSSMTENTSSTSSDITPTNSGQLDNNPLFYMVTNRWDAIPEEESNESR 387
                     ||.:.......::.|        .|.|.|                  |:|||..|.
Human   320 ---------AIHLCDKKKMELSLN--------IPVNHG------------------PQEESCGSS 349

  Fly   388 NDSFNLTSSAEATQRLETIRNGMILMACKPMEQLTLDVEANGFDLSPSESSSSSTNAKSDGRERL 452
            ....| :.|.|.::.|...::...|      .:...|.........|...|..||   ..|.:|.
Human   350 QLHEN-SGSPETSRSLPAPQDNDFL------SRKAQDCYFMKLHHCPGNHSWDST---ISGSQRA 404

  Fly   453 TVTDTKPVMMTTDLSNNNGGIHAHSNGLLSHANGWQARDEELQE-------QEHEQEIVNSLDVD 510
            ...|.|    ||..|:      |..|.|.:..|     .|.||.       |...::|||.:   
Human   405 AFCDHK----TTPCSS------AIINPLSTAGN-----SERLQPGIAQQWIQSKREDIVNQM--- 451

  Fly   511 VDPDEDENDGTEQSLAEILDPELQPEPPIPNDAESQLIYRDHRHMAKEYLSVDTNLYYAQDFKDK 575
                      ||..|.:.||..|..:..:..|.|  |:.......:|....:||.....::|. |
Human   452 ----------TEACLNQSLDALLSRDLIMKEDYE--LVSTKPTRTSKVRQLLDTTDIQGEEFA-K 503

  Fly   576 LIVQMDRTEREQKQELLRKMKDKE--GLQSLYNNLQQQYASRQLAAGHHPQPHPHPHPNQLQHPH 638
            :|||              |:||.:  |||                          |:|..|....
Human   504 VIVQ--------------KLKDNKQMGLQ--------------------------PYPEILVVSR 528

  Fly   639 SHPPMHFLQDE 649
            | |.::.||::
Human   529 S-PSLNLLQNK 538

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tak1NP_524080.1 TyrKc 19..264 CDD:197581 83/265 (31%)
STKc_TAK1 25..275 CDD:270960 83/276 (30%)
RIPK2NP_003812.1 STKc_RIP2 20..303 CDD:270928 85/287 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 338..369 11/49 (22%)
CARD_RIP2_CARD3 438..524 CDD:176764 29/141 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0192
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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