DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tak1 and RIPK1

DIOPT Version :9

Sequence 1:	NP_524080.1	Gene:	Tak1 / 39659	FlyBaseID:	FBgn0026323	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_001341859.1	Gene:	RIPK1 / 8737	HGNCID:	10019	Length:	671	Species:	Homo sapiens

Alignment Length:	702	Identity:	145/702 - (20%)
Similarity:	269/702 - (38%)	Gaps:	169/702 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SLDALQAAYVDFSEITLREKVGHGSYGVVCKAVWRDK-LVAVKEFFAS----AEQKDIEKEVKQL 64
            ||:.::....||.|   ..::..|.:|.|.....|.: |:.:|..:..    ...:.:.:|.|.:
Human     6 SLNVIKMKSSDFLE---SAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMM 67

  Fly    65 SRVKHPNIIALHGISSYQQATYLIMEFAEGGSLHNFLHGKVKPAYSLAHAMSWARQCAEGLAYLH 129
            :|::|..::.|.|:...:....|:||:.|.|:|.:.|..::....|:...:  ..:..||:.|||
Human    68 NRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRI--ILEIIEGMCYLH 130

  Fly   130 AMTPKPLIHRDVKPLNLLLTNKGRNLKICDFGTVADKSTMMTNNR----------------GSAA 178
            .   |.:||:|:||.|:|:.| ..::||.|.|..:.|.....||.                |:..
Human   131 G---KGVIHKDLKPENILVDN-DFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLY 191

  Fly   179 WMAPEVFE--GSKYTEKCDIFSWAIVLWEVLSRKQPFKGIDNAYTIQWKIY---KGERP---PLL 235
            :||||...  .:|.|||.|::|:|:|||.:.:.|:|:   :||...|..|.   .|.||   .:.
Human   192 YMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPY---ENAICEQQLIMCIKSGNRPDVDDIT 253

  Fly   236 TTCPKRIEDLMTACWKTVPEDRPSM--------QYIVGVMHEIVKDYTGADKALEYTFVNQQIVT 292
            ..||:.|..||..||:..||.||:.        .:.:..:.|.|::..   |:|:..:.|:..|.
Human   254 EYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEEDV---KSLKKEYSNENAVV 315

  Fly   293 K--------------ESDGTVAAQPDSLSSQEGELSPSSTQLTPTTAANANVNAIAISKTTTSSM 343
            |              ....:...||.||.|.:|                     :.:.....|..
Human   316 KRMQSLQLDCVAVPSSRSNSATEQPGSLHSSQG---------------------LGMGPVEESWF 359

  Fly   344 TENTSSTSSDITPTNSGQLDNNPLFYMVTNRWDAIPEEESNESRNDSFNLTSSAEATQRLETIRN 408
            ..:......:..|:...:|.:...:::..:|.|...:::..:      |:..:.|..:|.....:
Human   360 APSLEHPQEENEPSLQSKLQDEANYHLYGSRMDRQTKQQPRQ------NVAYNREEERRRRVSHD 418

  Fly   409 GMILMACKPMEQLTLDVEANGFDLSPSESSSSSTNAKSDGRERLTVTDTKPVMMTTDLSNNNGGI 473
            .....  :|.|... :.|..|...|.:.|..::.:..|.    ||   ::|.:    |..|||..
Human   419 PFAQQ--RPYENFQ-NTEGKGTAYSSAASHGNAVHQPSG----LT---SQPQV----LYQNNGLY 469

  Fly   474 HAHSNG-----------------LLSHA----------------------NGWQARDEELQEQEH 499
            .:|..|                 :.||.                      :.....||.:
Human   470 SSHGFGTRPLDPGTAGPRVWYRPIPSHMPSLHNIPVPETNYLGNTPTMPFSSLPPTDESI----- 529

  Fly   500 EQEIVNSLDVDVDP-DEDENDGTEQSLAEILDPELQPEPPIPNDAESQLIYRD------------ 551
            :..|.||..:.:.. :..|..||..||.:..:...:.||.    |:.|.|:.:
Human   530 KYTIYNSTGIQIGAYNYMEIGGTSSSLLDSTNTNFKEEPA----AKYQAIFDNTTSLTDKHLDPI 590

  Fly   552 HRHMAKEYLSVDTNLYYAQDFKDKLIVQMDRTE-REQKQELLRKMKDKEGLQ 602
            ..::.|.:.:....|.:.|...|::....:|.. :|:..::|:|...:||::
Human   591 RENLGKHWKNCARKLGFTQSQIDEIDHDYERDGLKEKVYQMLQKWVMREGIK 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tak1	NP_524080.1	TyrKc	19..264	CDD:197581	76/281 (27%)
Tak1	NP_524080.1	STKc_TAK1	25..275	CDD:270960	78/286 (27%)
RIPK1	NP_001341859.1	STKc_RIP1	23..290	CDD:270929	76/275 (28%)
		Interaction with SQSTM1. /evidence=ECO:0000269\|PubMed:10356400	290..582		54/344 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	331..354		6/43 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	389..458		14/84 (17%)
		RIP homotypic interaction motif (RHIM). /evidence=ECO:0000269\|PubMed:11734559, ECO:0000269\|PubMed:29681455	531..547		3/15 (20%)
		Death_RIP1	583..668	CDD:260048	10/60 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810