Protein Alignment Tak1 and RIPK1

DIOPT Version :10

• Sequence 1: NP_524080.1
• Gene: Tak1 / 39659
• FlyBaseID: FBgn0026323
• Length: 678
• Species: Drosophila melanogaster
• Sequence 2: XP_047275401.1
• Gene: RIPK1 / 8737
• HGNCID: 10019
• Length: 712
• Species: Homo sapiens
• Alignment Length: 702
• Identity: 145/702 - (20%)
• Similarity: 269/702 - (38%)
• Gaps: 169/702 - (24%)

  Fly     5 SLDALQAAYVDFSEITLREKVGHGSYGVVCKAVWRDK-LVAVKEFFAS----AEQKDIEKEVKQL 64
            ||:.::....||.|   ..::..|.:|.|.....|.: |:.:|..:..    ...:.:.:|.|.:
Human    47 SLNVIKMKSSDFLE---SAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMM 108

  Fly    65 SRVKHPNIIALHGISSYQQATYLIMEFAEGGSLHNFLHGKVKPAYSLAHAMSWARQCAEGLAYLH 129
            :|::|..::.|.|:...:....|:||:.|.|:|.:.|..::....|:...:  ..:..||:.|||
Human   109 NRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRI--ILEIIEGMCYLH 171

  Fly   130 AMTPKPLIHRDVKPLNLLLTNKGRNLKICDFGTVADKSTMMTNNR----------------GSAA 178
            .   |.:||:|:||.|:|:.| ..::||.|.|..:.|.....||.                |:..
Human   172 G---KGVIHKDLKPENILVDN-DFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLY 232

  Fly   179 WMAPEVFE--GSKYTEKCDIFSWAIVLWEVLSRKQPFKGIDNAYTIQWKIY---KGERP---PLL 235
            :||||...  .:|.|||.|::|:|:|||.:.:.|:|:   :||...|..|.   .|.||   .:.
Human   233 YMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPY---ENAICEQQLIMCIKSGNRPDVDDIT 294

  Fly   236 TTCPKRIEDLMTACWKTVPEDRPSM--------QYIVGVMHEIVKDYTGADKALEYTFVNQQIVT 292
            ..||:.|..||..||:..||.||:.        .:.:..:.|.|::..   |:|:..:.|:..|.
Human   295 EYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEEDV---KSLKKEYSNENAVV 356

  Fly   293 K--------------ESDGTVAAQPDSLSSQEGELSPSSTQLTPTTAANANVNAIAISKTTTSSM 343
            |              ....:...||.||.|.:|                     :.:.....|..
Human   357 KRMQSLQLDCVAVPSSRSNSATEQPGSLHSSQG---------------------LGMGPVEESWF 400

  Fly   344 TENTSSTSSDITPTNSGQLDNNPLFYMVTNRWDAIPEEESNESRNDSFNLTSSAEATQRLETIRN 408
            ..:......:..|:...:|.:...:::..:|.|...:::..:      |:..:.|..:|.....:
Human   401 APSLEHPQEENEPSLQSKLQDEANYHLYGSRMDRQTKQQPRQ------NVAYNREEERRRRVSHD 459

  Fly   409 GMILMACKPMEQLTLDVEANGFDLSPSESSSSSTNAKSDGRERLTVTDTKPVMMTTDLSNNNGGI 473
            .....  :|.|... :.|..|...|.:.|..::.:..|.    ||   ::|.:    |..|||..
Human   460 PFAQQ--RPYENFQ-NTEGKGTAYSSAASHGNAVHQPSG----LT---SQPQV----LYQNNGLY 510

  Fly   474 HAHSNG-----------------LLSHA----------------------NGWQARDEELQEQEH 499
            .:|..|                 :.||.                      :.....||.:
Human   511 SSHGFGTRPLDPGTAGPRVWYRPIPSHMPSLHNIPVPETNYLGNTPTMPFSSLPPTDESI----- 570

  Fly   500 EQEIVNSLDVDVDP-DEDENDGTEQSLAEILDPELQPEPPIPNDAESQLIYRD------------ 551
            :..|.||..:.:.. :..|..||..||.:..:...:.||.    |:.|.|:.:
Human   571 KYTIYNSTGIQIGAYNYMEIGGTSSSLLDSTNTNFKEEPA----AKYQAIFDNTTSLTDKHLDPI 631

  Fly   552 HRHMAKEYLSVDTNLYYAQDFKDKLIVQMDRTE-REQKQELLRKMKDKEGLQ 602
            ..::.|.:.:....|.:.|...|::....:|.. :|:..::|:|...:||::
Human   632 RENLGKHWKNCARKLGFTQSQIDEIDHDYERDGLKEKVYQMLQKWVMREGIK 683

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tak1	NP_524080.1	STKc_TAK1	25..275	CDD:270960	78/286 (27%)
RIPK1	XP_047275401.1	STKc_RIP1	64..331	CDD:270929	76/275 (28%)
		Death_RIP1	624..709	CDD:260048	10/60 (17%)