Protein Alignment Tak1 and ARK1

DIOPT Version :10

• Sequence 1: NP_524080.1
• Gene: Tak1 / 39659
• FlyBaseID: FBgn0026323
• Length: 678
• Species: Drosophila melanogaster
• Sequence 2: NP_014378.1
• Gene: ARK1 / 855711
• SGDID: S000004965
• Length: 638
• Species: Saccharomyces cerevisiae
• Alignment Length: 681
• Identity: 146/681 - (21%)
• Similarity: 257/681 - (37%)
• Gaps: 169/681 - (24%)

  Fly    27 HGSYGVVCKAVWRDKLVAVKEFFASAEQKDIEKEVKQLSRVKHPNIIA-----------LHGISS 80
            |.:..|.|.     |.|.|.:   ......:..||..:..:|:...:.           ||. .|
Yeast    47 HSNSSVACL-----KRVIVPD---KPSLNTLRAEVDAMRLLKNNRYVVSYIDSHAAKAMLHN-GS 102

  Fly    81 YQQATYLIMEFAEGGSLHNFLHGKVK---PAYSLAHAMSWARQCAEGLAYLHAMTPKPLIHRDVK 142
            |:  .:::||:.|.|.|.:|::.:::   ..:.:...||   |..:|:|.:||:.| ||||||:|
Yeast   103 YE--VFVLMEYCERGGLIDFMNTRLQNRLHEFEILQIMS---QVTQGVAAMHALQP-PLIHRDIK 161

  Fly   143 PLNLLLTNKGRNLKICDFGTVAD--------------KSTMMTNNRGSAAWMAPEV---FEGSKY 190
            ..|:|: :.....|:||||:|..              :..::.|.  :|.:.:||:   |.|...
Yeast   162 IENVLI-SANNEYKLCDFGSVCGIIRPPRNSQELSYVQQDILKNT--TAQYRSPEMIDTFRGLPI 223

  Fly   191 TEKCDIFSWAIVLWEVLSRKQPF-KGIDNAYTIQWKIYKGE-RPPLLTTCPKRIEDLMTACWKTV 253
            .||.||::..|.|:::.....|| ||.|.|      |..|: ..||.....::::.|:.......
Yeast   224 DEKSDIWALGIFLYKLCYYTTPFEKGGDLA------ILSGKFEFPLYPNYSEQLKGLIRDILVQD 282

  Fly   254 PEDRPSMQYI---VGVMHEI---VKDYTGADKALEYTFVNQQIVTKESDGTVAAQPDSLSSQEGE 312
            |..||::..:   :.:|..:   :.|.              |:|...|......:...||:.:..
Yeast   283 PRHRPNVYQLLKRISIMQNVPCPINDI--------------QVVQAPSSHLNLTELHQLSATQNI 333

  Fly   313 LSPSSTQLTPTTAANANVNAIAISKTTTSSMTEN--TSSTSSDITPTNSGQLDNNPLFYMVTNRW 375
            ||.:|......|..||.........|||:.|..|  .|..:.|.:.:||.: .:.|||....|.:
Yeast   334 LSLNSPTTMENTMPNATFQISMADNTTTAQMHPNRKPSQIAYDASFSNSAK-GSQPLFDKSQNMY 397

  Fly   376 DAI--PEEE---SNESRNDSFNLTSSAEATQRLETIRNGMILMACKPMEQLTLDVEANGFDLSPS 435
            .|:  |..|   |:.|.||  |...:..||:    ::..::..|....:..::|...........
Yeast   398 HALDPPLVEPLASSVSNND--NELKANSATK----LKQAIVSEAHTFRQNNSIDFPLQNIIPQYE 456

  Fly   436 ESSSSSTNAKSDGRERLTVTDTKPVMMTTDLSNNNGGIHAH--SNGL-------------LSHAN 485
            :|||||..:.|...:.|..|.:.....|......|..:...  |:.|             |.|.|
Yeast   457 DSSSSSDESYSGDVDELKKTRSLGSYSTRGNIKKNQSVKESLTSSSLPGTSFTPTSTKVNLKHEN 521

  Fly   486 GWQARDEELQEQEHEQEIVNSLDVDVD----PDEDENDGTEQSLAEILDPELQPEPPIPNDAESQ 546
                       ...:...||::|...|    |..::.|.::|:|              .|..:.:
Yeast   522 -----------SPFKSTFVNTIDNSKDDLNKPSYEDLDVSKQNL--------------KNSIQQR 561

  Fly   547 LIYRDHRHMAKEYLSVDTNLYYAQDFKDKLIVQMDRTEREQKQELLRKMKDKEGLQSLYNNLQQQ 611
            :|  |..:.::|..:..               :|.:.:..:|.|:     ||..:..
Yeast   562 MI--DKLNSSEESFNAR---------------KMSKVKLHEKGEI-----DKPTMLK-------- 596

  Fly   612 YASRQLAAGHHPQPHPHPHPNQLQHPHSHPP 642
             :|..::.....:|.|.|.|:.|:   ..||
Yeast   597 -SSGPISKDKKTKPTPPPKPSHLK---PKPP 623

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tak1	NP_524080.1	STKc_TAK1	25..275	CDD:270960	70/286 (24%)
ARK1	NP_014378.1	STKc_NAK_like	18..301	CDD:270939	69/277 (25%)