DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tak1 and tnni3k

DIOPT Version :9

Sequence 1:	NP_524080.1	Gene:	Tak1 / 39659	FlyBaseID:	FBgn0026323	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_001191752.1	Gene:	tnni3k / 799621	ZFINID:	ZDB-GENE-081104-399	Length:	835	Species:	Danio rerio

Alignment Length:	414	Identity:	120/414 - (28%)
Similarity:	187/414 - (45%)	Gaps:	72/414 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 YVDFSEITLREKVGHGSYGVVCKAVWRDKLVAVKEF----FASAEQKDIE-KEVKQLSRVKHPNI 72
            ::..||:...|.:|.||:|.|.|...|:|:||:|.:    :.|....|:. :||..|.|:.||.:
Zfish   457 HLQLSELEFNEIIGSGSFGKVYKGKCRNKIVAIKRYRPNTYCSKSDTDMFCREVSILCRLNHPCV 521

  Fly    73 IALHGISSYQQATY-LIMEFAEGGSLHNFLHGKVKPAYSLAHAMSWARQCAEGLAYLHAMTPKPL 136
            |...|......:.: ::.::..||||.:.|| :.|....|...:..|...|:|:.|||.:| :|:
Zfish   522 IQFVGACLDDPSQFAIVTQYVSGGSLFSLLH-EQKRIIDLQSKLIIAIDVAKGMEYLHNLT-QPI 584

  Fly   137 IHRDVKPLNLLLTNKGRNLKICDFG----TVADKSTMMTNNRGSAAWMAPEVF-EGSKYTEKCDI 196
            ||||:...|:||...|..: :.|||    .::.....||...|:..||||||| :.::||.|.|:
Zfish   585 IHRDLNSHNILLYEDGHAV-VADFGESRFLLSVDEDNMTKQPGNLRWMAPEVFTQCTRYTVKADM 648

  Fly   197 FSWAIVLWEVLSRKQPFKGIDNAYTIQWKIYKGERPPLLTTCPKRIEDLMTACWKTVPEDRPSMQ 261
            ||:|:.|||:|:.:.||..:..|.......|...|||:..:.||.|..|:...|...||:||...
Zfish   649 FSYALCLWELLTGEIPFAHLKPAAAAADMAYHHVRPPIGYSIPKPISALLMRGWNVCPEERPEFS 713

  Fly   262 YIVGVMHEIVKDYTGADKALEYTFVNQQIVTKESDGTVAAQPDSLSSQEGELSPSSTQLTPTTAA 326
            .:|.              .||....|.::::..|           |:..|.|||||:  |...||
Zfish   714 EVVA--------------KLEECLCNVELMSPAS-----------SNSSGSLSPSSS--TDCLAA 751

  Fly   327 NAN------------------VNAIAISKTTTSSMTENTSSTSSD-------ITPTNSGQLDNNP 366
            ..:                  :||.|.:..|.:|...::...|.|       ..|.:.....::|
Zfish   752 RGSPGRSHVAALRSRFELEYALNARAYAFWTQNSARRSSQGLSLDEMRRNMQFPPIDRNGYVSDP 816

  Fly   367 LFYMVTNRWDAIPEEESNESRNDS 390
               |.|.|:.:.   .||.|..||
Zfish   817 ---MSTMRFHSC---SSNGSFEDS 834

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tak1	NP_524080.1	TyrKc	19..264	CDD:197581	86/255 (34%)
Tak1	NP_524080.1	STKc_TAK1	25..275	CDD:270960	86/260 (33%)
tnni3k	NP_001191752.1	ANK	<56..121	CDD:238125
		Ank_4	67..121	CDD:290365
		ANK repeat	67..98	CDD:293786
		ANK	99..220	CDD:238125
		ANK repeat	100..131	CDD:293786
		Ank_2	105..195	CDD:289560
		ANK repeat	136..164	CDD:293786
		ANK	161..290	CDD:238125
		ANK repeat	166..197	CDD:293786
		Ank_2	171..261	CDD:289560
		ANK repeat	199..232	CDD:293786
		ANK	229..360	CDD:238125
		ANK repeat	269..302	CDD:293786
		Ank_2	274..369	CDD:289560
		ANK repeat	304..337	CDD:293786
		ANK	334..>401	CDD:238125
		ANK repeat	339..369	CDD:293786
		Ank_2	344..>411	CDD:289560
		TyrKc	463..719	CDD:197581	87/272 (32%)
		PKc_TNNI3K	469..722	CDD:270966	88/269 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810