DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tak1 and LRRK1

DIOPT Version :9

Sequence 1:	NP_524080.1	Gene:	Tak1 / 39659	FlyBaseID:	FBgn0026323	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_078928.3	Gene:	LRRK1 / 79705	HGNCID:	18608	Length:	2015	Species:	Homo sapiens

Alignment Length:	330	Identity:	94/330 - (28%)
Similarity:	148/330 - (44%)	Gaps:	74/330 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 VGHGSYG-VVCKAVWRDKLVAVKEF-------FASAEQ----------------KDIEKEVKQLS 65
            :|.|..| |:.:|.::.:.||||.|       ||:...                .:..:|...|.
Human  1248 LGQGGSGTVIYRARYQGQPVAVKRFHIKKFKNFANVPADTMLRHLRATDAMKNFSEFRQEASMLH 1312

  Fly    66 RVKHPNIIALHGISSYQQATYLIMEFAEGGSLHNFLHGKVKPA--YSLAHAMSW--ARQCAEGLA 126
            .::||.|:||.|||.:...  ..:|.|...||:..|....:.:  ..|.|.::.  |.|.|.|||
Human  1313 ALQHPCIVALIGISIHPLC--FALELAPLSSLNTVLSENARDSSFIPLGHMLTQKIAYQIASGLA 1375

  Fly   127 YLHAMTPKPLIHRDVKPLNLLL----TNKGRNLKICDFGTVADKS--TMMTNNRGSAAWMAPEVF 185
            |||   .|.:|..|:|..|:|:    ..:..|:|:.|:| ::.:|  .......|:..:.|||:.
Human  1376 YLH---KKNIIFCDLKSDNILVWSLDVKEHINIKLSDYG-ISRQSFHEGALGVEGTPGYQAPEIR 1436

  Fly   186 EGSKYTEKCDIFSWAIVLWEVLSRKQPFKGIDNAYTIQWKIYKGERPPLLTTCP-----KRIEDL 245
            ....|.||.|:||:.:||:|:||.::|..| .:...|..|:.||.||.|  ..|     :|::.|
Human  1437 PRIVYDEKVDMFSYGMVLYELLSGQRPALG-HHQLQIAKKLSKGIRPVL--GQPEEVQFRRLQAL 1498

  Fly   246 MTACWKTVPEDRPSMQYIVG---------VMHEIV------------KDYT-----GADKALEYT 284
            |..||.|.||.||....:|.         .|:|:.            ::||     |.:::..||
Human  1499 MMECWDTKPEKRPLALSVVSQMKDPTFATFMYELCCGKQTAFFSSQGQEYTVVFWDGKEESRNYT 1563

  Fly   285 FVNQQ 289
            .||.:
Human  1564 VVNTE 1568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tak1	NP_524080.1	TyrKc	19..264	CDD:197581	84/277 (30%)
Tak1	NP_524080.1	STKc_TAK1	25..275	CDD:270960	87/309 (28%)
LRRK1	NP_078928.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	26..56
		ANK 1	86..116
		ANK	95..214	CDD:238125
		ANK 2	119..148
		Ank_2	126..221	CDD:289560
		ANK 3	152..182
		ANK repeat	156..186	CDD:293786
		ANK repeat	188..218	CDD:293786
		ANK 4	193..222
		LRR_RI	<214..488	CDD:238064
		LRR 1	279..300
		leucine-rich repeat	281..303	CDD:275380
		LRR	302..614	CDD:227223
		LRR 2	303..324
		leucine-rich repeat	304..330	CDD:275380
		LRR 3	330..351
		leucine-rich repeat	331..353	CDD:275380
		LRR 4	353..374
		leucine-rich repeat	354..381	CDD:275380
		LRR_RI	379..641	CDD:238064
		LRR 5	381..402
		leucine-rich repeat	382..405	CDD:275380
		LRR 6	405..426
		leucine-rich repeat	406..451	CDD:275380
		LRR 7	427..447
		LRR 8	451..472
		leucine-rich repeat	452..474	CDD:275380
		LRR 9	474..495
		leucine-rich repeat	475..498	CDD:275380
		LRR 10	498..519
		leucine-rich repeat	499..549	CDD:275380
		LRR 11	549..570
		leucine-rich repeat	550..572	CDD:275380
		LRR 12	572..594
		LRR 13	596..617
		Gem1	635..>781	CDD:224025
		P-loop_NTPase	639..821	CDD:304359
		COR	844..1036	CDD:292713
		S_TKc	1245..1511	CDD:214567	82/271 (30%)
		STKc_LRRK1	1248..1523	CDD:270969	85/283 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1788..1810
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1841..1899
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900