DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tak1 and Mlkl

DIOPT Version :9

Sequence 1:	NP_524080.1	Gene:	Tak1 / 39659	FlyBaseID:	FBgn0026323	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_001297542.1	Gene:	Mlkl / 74568	MGIID:	1921818	Length:	472	Species:	Mus musculus

Alignment Length:	243	Identity:	57/243 - (23%)
Similarity:	105/243 - (43%)	Gaps:	42/243 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 EVKQLSRVKHPNIIALHGISSYQQAT----YLIMEFAEGGSLHNFLHGKVKPAYSLAHAMSWARQ 120
            |:|.:.:...|||:.:.||...|...    .::||:.|.|:|...|..:.....|:...:  ..:
Mouse   239 EIKTMKKFDSPNILRIFGICIDQTVKPPEFSIVMEYCELGTLRELLDREKDLTMSVRSLL--VLR 301

  Fly   121 CAEGLAYLHAMTPKPLIHRDVKPLNLLLTNKGRNLKICDF--------------GTVADKSTMMT 171
            .|.||..||   ....:||::...:.|:.. |..:|:..|              .|.|::|:
Mouse   302 AARGLYRLH---HSETLHRNISSSSFLVAG-GYQVKLAGFELSKTQNSISRTAKSTKAERSS--- 359

  Fly   172 NNRGSAAWMAPEVFEG--SKYTEKCDIFSWAIVLWEVLSRKQPFKGIDNAYTIQWKIYKGERPPL 234
                |..:::||..:.  ..|..|.:|:|:.|||||:.:.|.||:|.|:....:......::.|:
Mouse   360 ----STIYVSPERLKNPFCLYDIKAEIYSFGIVLWEIATGKIPFEGCDSKKIRELVAEDKKQEPV 420

  Fly   235 LTTCPKRIEDLMTACWKTVPEDRPSMQYIVGVMHEIVKDYTGADKALE 282
            ...||:.:.:::..|....|..|||:.         .:..:|.::.||
Mouse   421 GQDCPELLREIINECRAHEPSQRPSVD---------GRSLSGRERILE 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tak1	NP_524080.1	TyrKc	19..264	CDD:197581	54/223 (24%)
Tak1	NP_524080.1	STKc_TAK1	25..275	CDD:270960	54/234 (23%)
Mlkl	NP_001297542.1	N-terminal bundle and brace (NBB), mediates INSP6 binding. /evidence=ECO:0000250\|UniProtKB:Q8NB16	1..143
Mlkl	NP_001297542.1	PHA02988	198..446	CDD:165291	53/219 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900