DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tak1 and MAP3K7

DIOPT Version :9

Sequence 1:	NP_524080.1	Gene:	Tak1 / 39659	FlyBaseID:	FBgn0026323	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_663304.1	Gene:	MAP3K7 / 6885	HGNCID:	6859	Length:	606	Species:	Homo sapiens

Alignment Length:	668	Identity:	230/668 - (34%)
Similarity:	329/668 - (49%)	Gaps:	151/668 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MATASLDALQAAYVDFSEITLREKVGHGSYGVVCKAVWRDKLVAVKEFFASAEQKDIEKEVKQLS 65
            |..|....|....:|:.||.:.|.||.|::||||||.||.|.||:|:..:.:|:|....|::|||
Human    18 MIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLS 82

  Fly    66 RVKHPNIIALHGISSYQQATYLIMEFAEGGSLHNFLHG-KVKPAYSLAHAMSWARQCAEGLAYLH 129
            ||.||||:.|:|  :......|:||:||||||:|.||| :..|.|:.||||||..||::|:||||
Human    83 RVNHPNIVKLYG--ACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLH 145

  Fly   130 AMTPKPLIHRDVKPLNLLLTNKGRNLKICDFGTVADKSTMMTNNRGSAAWMAPEVFEGSKYTEKC 194
            :|.||.|||||:||.||||...|..||||||||..|..|.||||:||||||||||||||.|:|||
Human   146 SMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNKGSAAWMAPEVFEGSNYSEKC 210

  Fly   195 DIFSWAIVLWEVLSRKQPFKGIDN-AYTIQWKIYKGERPPLLTTCPKRIEDLMTACWKTVPEDRP 258
            |:|||.|:||||::|::||..|.. |:.|.|.::.|.||||:...||.||.|||.||...|..||
Human   211 DVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRP 275

  Fly   259 SMQYIVGVMHEIVKDYTGADKALEYTFVNQQIVTKESDGTVAAQPDSLSSQEGELSPSSTQLTPT 323
            ||:.||.:|..:::.:.|||:.|:|                    ....|.||:.:
Human   276 SMEEIVKIMTHLMRYFPGADEPLQY--------------------PCQYSDEGQSN--------- 311

  Fly   324 TAANANVNAIAISKTTTSSMTENTSSTSSDITPTNSGQLDNNPLFYMVTNRWDAIPEEESNESRN 388
                        |.|:|.|..:..|:.:|:.:.||..|:.       .||  |.|...||...:|
Human   312 ------------SATSTGSFMDIASTNTSNKSDTNMEQVP-------ATN--DTIKRLESKLLKN 355

  Fly   389 DSFNLTSSAEATQRLETIRNGMILMACKPMEQL--TLDVEANGFDLSPSESSSSSTNAKS----- 446
                     :|.|:.|:.|..:.......:|.|  |.:.:....|:|..|:..::|.|.|
Human   356 ---------QAKQQSESGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEARIAATTAYSKPKRG 411

  Fly   447 --------------------DGRER------LTVTDTKP------------VMMTTDLSNNNGGI 473
                                :|:.|      ||||.|:|            .|:||....:....
Human   412 HRKTASFGNILDVPEIVISGNGQPRRRSIQDLTVTGTEPGQVSSRSSSPSVRMITTSGPTSEKPT 476

  Fly   474 HAHSNGLLSHANGWQARDEELQEQEHEQEIVNSLDVDVDPDED-ENDGTEQSLAE---ILDPELQ 534
            .:|.         |                        .||:. :.:|::.|:..   .||.:||
Human   477 RSHP---------W------------------------TPDDSTDTNGSDNSIPMAYLTLDHQLQ 508

  Fly   535 PEPPIPNDAESQLIYRDHRHMAKEYLSVDTNLYYAQDFKDKLIVQMDRTEREQK------QELLR 593
            |..|.||..||..::..|..||:||:.|.|.:......|.:|:.::|:.|::|:      ||..:
Human   509 PLAPCPNSKESMAVFEQHCKMAQEYMKVQTEIALLLQRKQELVAELDQDEKDQQNTSRLVQEHKK 573

  Fly   594 KMKDKEGLQSLYNNLQQQ 611
            .:.:.:.|.:.|...::|
Human   574 LLDENKSLSTYYQQCKKQ 591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tak1	NP_524080.1	TyrKc	19..264	CDD:197581	141/246 (57%)
Tak1	NP_524080.1	STKc_TAK1	25..275	CDD:270960	142/251 (57%)
MAP3K7	NP_663304.1	Interaction with MAPK8IP1. /evidence=ECO:0000250	1..300		153/283 (54%)
		STKc_TAK1	42..292	CDD:270960	142/251 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	301..338		11/57 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	354..391		8/45 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	443..493		14/82 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	293	1.000	Domainoid score	I1510
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	349	1.000	Inparanoid score	I2291
Isobase	1	0.950	-	0	Normalized mean entropy	S3561
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D346131at33208
OrthoFinder	1	1.000	-	-		FOG0000676
OrthoInspector	1	1.000	-	-		oto89743
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4191
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.780