DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tak1 and Lrrk2

DIOPT Version :9

Sequence 1:NP_524080.1 Gene:Tak1 / 39659 FlyBaseID:FBgn0026323 Length:678 Species:Drosophila melanogaster
Sequence 2:NP_080006.3 Gene:Lrrk2 / 66725 MGIID:1913975 Length:2527 Species:Mus musculus


Alignment Length:647 Identity:142/647 - (21%)
Similarity:245/647 - (37%) Gaps:174/647 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    25 VGHGSYGVVCKAVWRDKLVAVKEFFASAEQKDIEKEVKQLSRVKHPNIIALHGISSYQQATYLIM 89
            :|.||:|.|.:|.:..:.||||.|......:.:.:|:..|..:.||::|:|  :::..:...|:|
Mouse  1885 LGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQELVVLCHLHHPSLISL--LAAGIRPRMLVM 1947

  Fly    90 EFAEGGSLHNFL-HGKVKPAYSLAHAMSWARQCAEGLAYLHAMTPKPLIHRDVKPLNLLL----T 149
            |.|..|||...| ..|.....:|.|.:  |...|:||.|||:..   :|:||:||.|:||    .
Mouse  1948 ELASKGSLDRLLQQDKASLTRTLQHRI--ALHVADGLRYLHSAM---IIYRDLKPHNVLLFTLYP 2007

  Fly   150 NKGRNLKICDFGTVADKSTMM--TNNRGSAAWMAPEVFEGSK-YTEKCDIFSWAIVL---WEVLS 208
            |.....||.|:| :|.....|  ..:.|:..:.||||..|:. |.::.|::|:.::|   |...|
Mouse  2008 NAAIIAKIADYG-IAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLLHDIWTTGS 2071

  Fly   209 RKQPFKGIDNAY---TIQWKI------YKGERPPLLTTCPKRIEDLMTACWKTVPEDRPSMQYIV 264
            |........|.:   .||.|:      |.....|:       :|.|:|.|.|..|::||:...:.
Mouse  2072 RIMEGLRFPNEFDELAIQGKLPDPVKEYGCAPWPM-------VEKLITKCLKENPQERPTSAQVF 2129

  Fly   265 GVMH--EIVKDYTGADKALEYTFVNQQIVTKESDGTVAAQPDSLS---------SQEGELSPSST 318
            .:::  |::       ..:.:..:.:.|:.   :..||...:|.|         :::|:||    
Mouse  2130 DILNSAELI-------CLMRHILIPKNIIV---ECMVATNLNSKSATLWLGCGNTEKGQLS---- 2180

  Fly   319 QLTPTTAANANVNAIAISKTTTSSMTENTSSTSS-DITPTNSGQLDNNPLFYMVTNRWDAIPEEE 382
             |........:...:|.|:....::....:...| .:..|.||.|       :|.|     .|||
Mouse  2181 -LFDLNTERYSYEEVADSRILCLALVHLAAEKESWVVCGTQSGAL-------LVIN-----VEEE 2232

  Fly   383 SNESRNDSFNLTSSAEATQRLETIRNGMILMACKPMEQLTLDVEANGFDLSPSESSSSSTNAKSD 447
            :..               ..||.:.:.:..:.|..:.:             .|:.|:......:|
Mouse  2233 TKR---------------HTLEKMTDSVTCLHCNSLAK-------------QSKQSNFLLVGTAD 2269

  Fly   448 GR-----------------ERLTVTDTKPVMMTTDLSNNNGGIHAHSNGLLSHANGWQARDEELQ 495
            |.                 :.|.:.|....:|....|.|:...|....|..:....:        
Mouse  2270 GNLMIFEDKAVKCKGAAPLKTLHIGDVSTPLMCLSESLNSSERHITWGGCGTKVFSF-------- 2326

  Fly   496 EQEHEQEIVNSLDVDVDPDEDENDGTEQSLAEILDPELQPEPPIPNDAESQLIYRDHRHMAKEYL 560
                                 .||.|.|.|.|..          .|...|...:.|...:|   |
Mouse  2327 ---------------------SNDFTIQKLIETK----------TNQLFSYAAFSDSNIIA---L 2357

  Fly   561 SVDTNLYYAQDFKDKLIVQMDRTEREQKQELLRKMKD-----KEGLQSLYNNLQQQ--YASR 615
            :|||.||.|:  |:..:|::    .::|.|.|.::.|     ||.:..|....:.|  |:.|
Mouse  2358 AVDTALYIAK--KNSPVVEV----WDKKTEKLCELIDCVHFLKEVMVKLNKESKHQLSYSGR 2413

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tak1NP_524080.1 TyrKc 19..264 CDD:197581 77/258 (30%)
STKc_TAK1 25..275 CDD:270960 78/271 (29%)
Lrrk2NP_080006.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 957..979
LRR 1 983..1004
leucine-rich repeat 985..1012 CDD:275380
LRR 2 1012..1033
leucine-rich repeat 1013..1036 CDD:275380
LRR 3 1036..1057
leucine-rich repeat 1037..1059 CDD:275380
LRR 4 1059..1080
leucine-rich repeat 1060..1084 CDD:275380
LRR 5 1084..1105
leucine-rich repeat 1085..1108 CDD:275380
LRR 6 1108..1129
leucine-rich repeat 1109..1130 CDD:275380
LRR 7 1130..1151
leucine-rich repeat 1131..1170 CDD:275380
leucine-rich repeat 1171..1197 CDD:275380
LRR 8 1174..1195
LRR 9 1197..1218
leucine-rich repeat 1198..1221 CDD:275380
LRR 10 1221..1242
leucine-rich repeat 1222..1246 CDD:275380
LRR 11 1246..1267
LRR 12 1269..1291
leucine-rich repeat 1270..1291 CDD:275380
Gem1 1333..1551 CDD:224025
RocCOR 1334..1507 CDD:206741
COR 1527..1740 CDD:292713
STKc_LRRK2 1884..2135 CDD:270970 77/264 (29%)
S_TKc 1884..2128 CDD:214567 77/257 (30%)
WD 1 2139..2183 9/51 (18%)
WD 2 2188..2228 8/46 (17%)
WD 3 2233..2276 7/70 (10%)
WD 4 2281..2327 7/74 (9%)
WD 5 2333..2377 16/62 (26%)
WD 6 2402..2438 3/12 (25%)
WD 7 2443..2497
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0192
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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