Protein Alignment Tak1 and ripk1l

DIOPT Version :10

• Sequence 1: NP_524080.1
• Gene: Tak1 / 39659
• FlyBaseID: FBgn0026323
• Length: 678
• Species: Drosophila melanogaster
• Sequence 2: NP_001036815.1
• Gene: ripk1l / 567460
• ZFINID: ZDB-GENE-070705-132
• Length: 661
• Species: Danio rerio
• Alignment Length: 748
• Identity: 149/748 - (19%)
• Similarity: 241/748 - (32%)
• Gaps: 290/748 - (38%)

  Fly    13 YVDFSEITL--REKVGHGSYGVVCKAVWRDKLVAVKEFFASAEQK-DIEKEVKQLSRVKHPNIIA 74
            |..|.|:.|  .:.:||    ||.|.|:....       .|..|| .:.:|...:||:.|..::.
Zfish    23 YGGFGEVYLCYHKTLGH----VVLKTVYTGPP-------RSGRQKQSLLEEGSLMSRLNHQRVVK 76

  Fly    75 LHGISSYQQATYLIMEFAEGGSLHNFLHGKVKPAYSLAHAMSWARQCAEGLAYLHAMTPKPLIHR 139
            |.|:........|:||....|:|...|. ||....|:...:  ..:..||:.||   |...:||:
Zfish    77 LLGVILEDGDYSLVMELIPKGNLLTMLE-KVTVPISVKGRI--ILEILEGMVYL---TKNQVIHK 135

  Fly   140 DVKPLNLLLTNKGRNLKICDFG----TVADKSTMMTNNR-------------GSAAWMAPEVFEG 187
            |:||.|:|: :|..::||.|.|    .|..|.|...:.|             |:..:||||..:.
Zfish   136 DLKPENILV-DKNFHIKIADLGLATSEVWSKLTKEESRRQSRLGKKTSAHAAGTLCYMAPEHLKS 199

  Fly   188 --SKYTEKCDIFSWAIVLWEVLSRKQPFKGIDNAYTIQWKIYKGERPP---LLTTCPKRIEDLMT 247
              ::.:||.|::|:|||||.:|:.::|::...:...|...:.:||||.   :....|..|.|||.
Zfish   200 IHTRSSEKSDVYSFAIVLWVILTGREPYEDARSEDQICHCVCQGERPDEALIPPNTPTDITDLMK 264

  Fly   248 ACWKTVPEDRPSM----------------QYIVGVMHEIVKDYTGADKALEYTFVNQQIVTKESD 296
            :||...|..|||.                ..:...:..::|.|.|.::.:|...:
Zfish   265 SCWHQDPLQRPSFTDCYNRFLPFYKEKLAANVKADLENLMKLYEGPEELVEKLKL---------- 319

  Fly   297 GTVAAQPDSLSSQEGELSPSSTQLTPTTAANANVNAIAISKTTTSSMTENTSSTSSDITPTNSGQ 361
                                           .|.||:.....:..|....|...||||.|.
Zfish   320 -------------------------------LNTNALIPEDPSLCSRDSPTPLRSSDIGPV---- 349

  Fly   362 LDNNPLFYMVTNRWDAIPEEESNESRNDSFNLTSSAEATQRLETIRNGMILMACKPMEQLTLDVE 426
                          :|..|:.|..|..||   ...|:||.            :| |..:|.|:.|
Zfish   350 --------------EASIEDLSFRSCEDS---VLEADATP------------SC-PNLELKLEQE 384

  Fly   427 AN-------------GFDLSPSESSSSSTNAKSDGRERLTVTDTKPVMMTTDLSNNNGGIHAHSN 478
            .|             |...||::..:|||:|.|.
Zfish   385 YNYHKFGSRIVDQSDGSMWSPAQQPASSTDASSQ------------------------------- 418

  Fly   479 GLLSHANGWQARDEELQEQEHEQEIVNSLDVDVDPDEDENDGTEQSLAEILDPELQPEPPIPNDA 543
              :|....|........|:|.......|.|                  .:..|||:.:..:|...
Zfish   419 --MSSVKSWTKPSAPSTEEELYPRAAASFD------------------SLHRPELRSQFSVPQSD 463

  Fly   544 ESQLIYRDH---------------RHMAKEYLSVDTNL-------YYAQD--------------- 571
            ..:|  |.|               .|:|:..:..::||       |.|.|
Zfish   464 HERL--RPHAHLPWNRVKSCPEGANHVAESLIDTNSNLRFNSPVTYPASDSAFPVSISNASAIQI 526

  Fly   572 ----------------------------FKDKLIVQMDRTEREQKQELLRKM------------- 595
                                        :|:.|::....|..|...||:|:.
Zfish   527 GSYNTMNLRISDSSPYSSLSTTGSTTSRYKELLLMYESHTVTESHLELVRQNVGANWKQVARKLG 591

  Fly   596 ------------KDKEGLQSLYNNLQQQYASRQ 616
                        .|::||....:.:.:::..|:
Zfish   592 LSEIDVETIEHDYDRDGLTEKVHQMLERWKMRE 624

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tak1	NP_524080.1	STKc_TAK1	25..275	CDD:270960	78/288 (27%)
ripk1l	NP_001036815.1	STKc_RIP1	21..289	CDD:270929	81/283 (29%)
		Death_RIP1	568..653	CDD:260048	8/57 (14%)