DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tak1 and Ripk3

DIOPT Version :9

Sequence 1:	NP_524080.1	Gene:	Tak1 / 39659	FlyBaseID:	FBgn0026323	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_064339.2	Gene:	Ripk3 / 56532	MGIID:	2154952	Length:	486	Species:	Mus musculus

Alignment Length:	382	Identity:	96/382 - (25%)
Similarity:	166/382 - (43%)	Gaps:	75/382 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 VDFSEITLREKVGHGSYGVVCKA---VWRDKLVAVKEFFASAEQKDIEKEVKQLSRVKHPNIIAL 75
            |...|:...|.||.|.:|||.:|   .|... ||||    ....|.|..|||.:..:::.|::.|
Mouse    17 VSREELKKLEFVGKGGFGVVFRAHHRTWNHD-VAVK----IVNSKKISWEVKAMVNLRNENVLLL 76

  Fly    76 HGISSYQQATY-----LIMEFAEGGSLHNFLHGKVKPAYSLAHAMSWARQCAEGLAYLHAMTPKP 135
            .|::...|..:     |:..|.|.|||...|..:....:.|...:  .::...|:.|||::.| |
Mouse    77 LGVTEDLQWDFVSGQALVTRFMENGSLAGLLQPECPRPWPLLCRL--LQEVVLGMCYLHSLNP-P 138

  Fly   136 LIHRDVKPLNLLLTNKGRNLKICDFGTVADKSTMMTNNR-------------GSAAWMAPE-VFE 186
            |:|||:||.|:|| :...:.|:.|||.    ||....::             |:.|::.|| :|:
Mouse   139 LLHRDLKPSNILL-DPELHAKLADFGL----STFQGGSQSGSGSGSGSRDSGGTLAYLDPELLFD 198

  Fly   187 -GSKYTEKCDIFSWAIVLWEVLSRKQPFKGIDNAYTIQWKIY-KGERPPLLTTCP--------KR 241
             ..|.::..|::|:.|::|.||:.::. :.:|....|:..:. :..||||....|        ::
Mouse   199 VNLKASKASDVYSFGILVWAVLAGREA-ELVDKTSLIRETVCDRQSRPPLTELPPGSPETPGLEK 262

  Fly   242 IEDLMTACWKTVPEDRPSMQYI---VGVMHEIVKDYTGA-------------------------D 278
            :::||..||.:..|:|||.|..   ...::.:|||...|                         .
Mouse   263 LKELMIHCWGSQSENRPSFQDCEPKTNEVYNLVKDKVDAAVSEVKHYLSQHRSSGRNLSAREPSQ 327

  Fly   279 KALEYTFVNQQIVTKESDGTVAAQPDS-LSSQEGELSPSSTQLTPTTAANANVNAIA 334
            :..|.....:.:|:|..|.....:|.. :..:..|.....|.:.|.|.|..:.:.:|
Mouse   328 RGTEMDCPRETMVSKMLDRLHLEEPSGPVPGKCPERQAQDTSVGPATPARTSSDPVA 384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tak1	NP_524080.1	TyrKc	19..264	CDD:197581	79/279 (28%)
Tak1	NP_524080.1	STKc_TAK1	25..275	CDD:270960	81/284 (29%)
Ripk3	NP_064339.2	Pkinase	24..284	CDD:278497	79/273 (29%)
		PKc_like	28..284	CDD:304357	78/269 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	312..333		1/20 (5%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	349..388		7/36 (19%)
		RHIM	410..457	CDD:289491
		RIP homotypic interaction motif (RHIM). /evidence=ECO:0000269\|PubMed:18442983	440..461
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	462..486
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810