DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tak1 and map3k10

DIOPT Version :9

Sequence 1:	NP_524080.1	Gene:	Tak1 / 39659	FlyBaseID:	FBgn0026323	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	XP_689424.4	Gene:	map3k10 / 560932	ZFINID:	ZDB-GENE-050419-112	Length:	1062	Species:	Danio rerio

Alignment Length:	806	Identity:	176/806 - (21%)
Similarity:	304/806 - (37%)	Gaps:	190/806 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 VDFSEITLREKVGHGSYGVVCKAVWRDKLVAVK--------EFFASAEQKDIEKEVKQLSRVKHP 70
            :||.|:.|.|.:|.|.:|.|.|.|||.:.||||        :..|:||  ::.:|.:....::|.
Zfish   160 IDFLELRLEEVIGAGGFGKVYKGVWRAEEVAVKAARQDPDEDISATAE--NVRQEARLFWMLRHR 222

  Fly    71 NIIALHGISSYQQATYLIMEFAEGGSLHNFLHGKVKPAYSLAHAMSWARQCAEGLAYLHAMTPKP 135
            |||||.|:...:....|:||:|.||:|:..|.||..|...|   ::||.|.|.|:.|||..|..|
Zfish   223 NIIALRGVCLREPNLCLVMEYARGGALNRALAGKKVPPRVL---VNWAVQIATGMDYLHNQTFVP 284

  Fly   136 LIHRDVKPLNLLLTN-------KGRNLKICDFGTVAD--KSTMMTNNRGSAAWMAPEVFEGSKYT 191
            :||||:|..|:|:..       .|:.|||.|||...:  ::|.| :..|:.|||||||.:.|.::
Zfish   285 IIHRDLKSSNILILEPVERDDLSGKTLKITDFGLAREWHRTTKM-SAAGTYAWMAPEVIKLSLFS 348

  Fly   192 EKCDIFSWAIVLWEVLSRKQPFKGIDNAYTIQWKIYKGERP-PLLTTCPKRIEDLMTACWKTVPE 255
            :..|::|:.::|||:|:.:.|::.|| |..:.:.:...:.. |:.:|||:....|:..||...|.
Zfish   349 KSSDVWSFGVLLWELLTGEVPYREID-ALAVAYGVAMNKLTLPIPSTCPEAFAQLLGECWCPNPR 412

  Fly   256 DRPS----------------MQYIVGVMHEIVKDYTGADKALEYTFVNQQIVTKES-----DGTV 299
            .||:                .|..:...|.:.:|:     .||...:..::..||.     :..:
Zfish   413 GRPAFGSILKRLEDIEQSAMFQMPLESFHSLQEDW-----RLEIQQMFDELRAKEKELRSWEEAL 472

  Fly   300 AAQPDSLSSQEGELSPSSTQLT----PTTAANANV------------------------------ 330
            |...:....||..|.....:|.    .......|:
Zfish   473 ARAAEEQREQEEHLRRREQELAEREIDIVERELNIIIHQMYQEKPQVKKRKGNFKKSRLLKLGRD 537

  Fly   331 -NAIAISKTTTSSMTENTS---------STSSDITPTNSGQLDNNPLFYMVTN----RWDAI--- 378
             |.|::.......:|...|         |:.|...|.:.|.:.....|.:..:    .|...
Zfish   538 SNCISLPSGFEHKITVQASPSVDKRKCQSSESTTPPASPGVIPRLRAFRLTPSDGRKTWGRTAVC 602

  Fly   379 -PEEESNESRNDSFNLTSSAE-----ATQRLETIRNGMILMACKPMEQLTLDVEANGFDLSPSES 437
             .||...:.:..::..:|:.:     ...||:::..|.:..:..|           ....||..:
Zfish   603 KKEEPGTKKKGRTWGPSSTHQRERVGGEDRLKSLGEGKVWSSSAP-----------NLGKSPKHA 656

  Fly   438 -SSSSTNAKSDGRERLTVTDTKPVMMTTDLSNNNGGIHAHSNGLLSHANGWQARDEELQ-EQEHE 500
             .::..::.::..|.....|:.|..:..|| .:||.:....:|.....:|..::|...: .|..:
Zfish   657 PMTAGFSSLNEMEEHCEFDDSSPGRLAPDL-GSNGALEDVGSGSAGLGSGIGSQDSVCRCSQRKK 720

  Fly   501 QEI----------VNSLDVDV------DPDEDENDGTEQSLAEILDPELQPEPPIPNDAESQLIY 549
            .::          |..|..|:      ..::||.|..|:.                ...:..|..
Zfish   721 SDLLLLGCASLLAVVGLGSDILQLGRQQMNQDEQDVREEQ----------------RKKKEGLFQ 769

  Fly   550 RDHRHMAKE-------YLSVDTNLYYAQDFKDKLIVQMDRTEREQKQELLRKMKDKEGLQSLYNN 607
            |..|.....       .||:..|.::     |.::..||.:....... |..:.|....:||..:
Zfish   770 RTGRFRRSTSPPSRTLSLSLSHNRHH-----DSILPSMDPSPSVTLLS-LSSLSDCNSTKSLLPS 828

  Fly   608 LQQQYASRQLAAGH--HPQPHPHP-----------HPNQLQHPHSHPPMHFLQDEGCGLLPG--- 656
            ....:|.....|..  .|.|..:|           .|||...| :|.......:.|....|.
Zfish   829 DPDDFAPTPSNAPPVVSPAPALNPLLDLRAESFKREPNQSLTP-THVSATMALNRGHRRTPSDGA 892

  Fly   657 ------SVCGGSESVEEGWVVIPPHH 676
                  :|.|...:..:|.:..||.|
Zfish   893 IRPRAQTVVGHRRTPSDGSMPFPPAH 918

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tak1	NP_524080.1	TyrKc	19..264	CDD:197581	93/278 (33%)
Tak1	NP_524080.1	STKc_TAK1	25..275	CDD:270960	93/283 (33%)
map3k10	XP_689424.4	SH3_MLK1-3	81..138	CDD:212992
		STYKc	165..424	CDD:214568	92/265 (35%)
		STKc_MLK2	170..427	CDD:271050	90/263 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810