DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tak1 and RIPK4

DIOPT Version :9

Sequence 1:	NP_524080.1	Gene:	Tak1 / 39659	FlyBaseID:	FBgn0026323	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_065690.2	Gene:	RIPK4 / 54101	HGNCID:	496	Length:	784	Species:	Homo sapiens

Alignment Length:	406	Identity:	117/406 - (28%)
Similarity:	190/406 - (46%)	Gaps:	81/406 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 DFSEITLREKVGHGSYGVVCK---AVWRDKLVAVK----EFFASAEQKDIEKEVKQLSRVKHPNI 72
            |..|.|..||||.|.:|.|.|   ..|:..| |:|    ......|:.::.:|.|::...|...|
Human    18 DAGEFTGWEKVGSGGFGQVYKVRHVHWKTWL-AIKCSPSLHVDDRERMELLEEAKKMEMAKFRYI 81

  Fly    73 IALHGISSYQQATYLIMEFAEGGSLHNFLHGKVKP---AYSLAHAMSWARQCAEGLAYLHAMTPK 134
            :.::||.  ::...|:||:.|.|||...|..:..|   .:.:.|      :.|.|:.:||.|.|
Human    82 LPVYGIC--REPVGLVMEYMETGSLEKLLASEPLPWDLRFRIIH------ETAVGMNFLHCMAP- 137

  Fly   135 PLIHRDVKPLNLLLTNKGRNLKICDFGTVADKSTMMTNNR--------GSAAWMAPE-VFEGSK- 189
            ||:|.|:||.|:|| :...::||.|||..  |...::::.        |:.|::.|| :.|.|:
Human   138 PLLHLDLKPANILL-DAHYHVKISDFGLA--KCNGLSHSHDLSMDGLFGTIAYLPPERIREKSRL 199

  Fly   190 YTEKCDIFSWAIVLWEVLSRKQPFKGIDNAYTIQWKIYKGERPPLLTTCPKR------IEDLMTA 248
            :..|.|::|:|||:|.||::|:||....|...|..|:.||.||.|...|..|      :..||..
Human   200 FDTKHDVYSFAIVIWGVLTQKKPFADEKNILHIMVKVVKGHRPELPPVCRARPRACSHLIRLMQR 264

  Fly   249 CWKTVPEDRPSMQYIVGVMHEI-------VKDYTGAD-------------------KALEYTFVN 287
            ||:..|..||:.|.|.....::       ||: |..|                   :|...||.|
Human   265 CWQGDPRVRPTFQEITSETEDLCEKPDDEVKE-TAHDLDVKSPPEPRSEVVPARLKRASAPTFDN 328

  Fly   288 QQIVTKESDGTVAAQPDSLSSQ--EG--ELSPSSTQ-LTPTTAANANVNAI-----AISKTTTSS 342
            ...:::     :.:|.||..||  ||  |||.||:: ..|::.:...::.:     |.|...:.|
Human   329 DYSLSE-----LLSQLDSGVSQAVEGPEELSRSSSESKLPSSGSGKRLSGVSSVDSAFSSRGSLS 388

  Fly   343 MTENTSSTSSDITPTN 358
            ::.....::||:..|:
Human   389 LSFEREPSTSDLGTTD 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tak1	NP_524080.1	TyrKc	19..264	CDD:197581	87/270 (32%)
Tak1	NP_524080.1	STKc_TAK1	25..275	CDD:270960	87/282 (31%)
RIPK4	NP_065690.2	STKc_RIP4_like	25..290	CDD:270927	87/277 (31%)
		STYKc	26..279	CDD:214568	86/265 (32%)
		ANK	413..524	CDD:238125
		ANK repeat	437..468	CDD:293786
		Ank_2	442..534	CDD:289560
		ANK repeat	470..501	CDD:293786
		ANK	471..589	CDD:238125
		ANK repeat	503..534	CDD:293786
		Ank_2	508..600	CDD:289560
		ANK repeat	536..567	CDD:293786
		ANK repeat	569..600	CDD:293786
		ANK	598..723	CDD:238125
		ANK repeat	603..634	CDD:293786
		Ank_2	608..699	CDD:289560
		ANK repeat	636..667	CDD:293786
		ANK repeat	669..699	CDD:293786
		Ank_2	674..764	CDD:289560
		ANK	729..>764	CDD:238125
		ANK repeat	734..764	CDD:293786
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810