DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tak1 and MAP3K20

DIOPT Version :9

Sequence 1:	NP_524080.1	Gene:	Tak1 / 39659	FlyBaseID:	FBgn0026323	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_057737.2	Gene:	MAP3K20 / 51776	HGNCID:	17797	Length:	800	Species:	Homo sapiens

Alignment Length:	689	Identity:	161/689 - (23%)
Similarity:	270/689 - (39%)	Gaps:	204/689 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LDALQAAYVD--FSEITLREKVGHGSYGVVCKAVW--RDKLVAVKEFFASAEQKDIEKEVKQLSR 66
            :.:|.|::|.  |.::...|..|.||:|.|.:|.|  :||.||||:..      .||||.:.||.
Human     1 MSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLL------KIEKEAEILSV 59

  Fly    67 VKHPNIIALHGISSYQQATYLIMEFAEGGSLHNFLHGKVKPAYSLAHAMSWARQCAEGLAYLHAM 131
            :.|.|||..:|:........::.|:|..|||:::::........:.|.|:||...|:|:.|||..
Human    60 LSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHME 124

  Fly   132 TPKPLIHRDVKPLNLLLTNKGRNLKICDFGTVADKSTMMTNNR---GSAAWMAPEVFEGSKYTEK 193
            .|..:||||:|..|:::...| .|||||||  |.:....|.:.   |:..||||||.:....:|.
Human   125 APVKVIHRDLKSRNVVIAADG-VLKICDFG--ASRFHNHTTHMSLVGTFPWMAPEVIQSLPVSET 186

  Fly   194 CDIFSWAIVLWEVLSRKQPFKGIDNAYTIQWKIYKGERPPLLTTCPKRIEDLMTACWKTVPEDRP 258
            ||.:|:.:||||:|:|:.||||::........:.|.||..:.::||:...:|:..||:...:.||
Human   187 CDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRP 251

  Fly   259 SMQYIVGVMHEIVKDYTGADKALEY-------------------------TFVNQQIVTKESDGT 298
            |.:.|:.::..:..|.:..||...:                         :|..|::  ||.:..
Human   252 SFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERDLSFKEQEL--KERERR 314

  Fly   299 VAAQPDSLSSQEGELSPSSTQLTPTTAANANVNAIAISKTTTSSMTEN-----------TSSTSS 352
            :......|:.|      |:|.|.|:....|              .||:           ...:|:
Human   315 LKMWEQKLTEQ------SNTPLLPSFEIGA--------------WTEDDVYCWVQQLVRKGDSSA 359

  Fly   353 DITPTNSGQLDNNPLFYMVTNRWDAIPEEESNESRNDSFNLTSSAEATQRLETIRNGMILMACKP 417
            :::...|...:||     :|.:...:.|||.                .:.:..:..|.|:.....
Human   360 EMSVYASLFKENN-----ITGKRLLLLEEED----------------LKDMGIVSKGHIIHFKSA 403

  Fly   418 MEQLTLDVEANGFDLSPSESSSSSTNAKSDGRERLTVTDTKPVMMTTDLSNNNGGIHAHSNGLLS 482
            :|:||.|. .|.|...|                               |..::||
Human   404 IEKLTHDY-INLFHFPP-------------------------------LIKDSGG---------- 426

  Fly   483 HANGWQARDEELQEQEHEQEIVN--------------------SLDVDVDPDE-------DENDG 520
                        :.:|:|::|||                    .:.:::|.||       |....
Human   427 ------------EPEENEEKIVNLELVFGFHLKPGTGPQDCKWKMYMEMDGDEIAITYIKDVTFN 479

  Fly   521 TEQSLAEIL---DPELQPEPPIPNDAESQLIYRDHRHMAKEYLSVDTNLYYAQDF------KDKL 576
            |....||||   .|....|..|...|:||              :|:..:.|..|.      |...
Human   480 TNLPDAEILKMTKPPFVMEKWIVGIAKSQ--------------TVECTVTYESDVRTPKSTKHVH 530

  Fly   577 IVQMDRTEREQKQELLRKMKDKEGLQSLYNNLQQQYASR 615
            .:|..||:.:.:.:.::.     .:|:|:.|......||
Human   531 SIQWSRTKPQDEVKAVQL-----AIQTLFTNSDGNPGSR 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tak1	NP_524080.1	TyrKc	19..264	CDD:197581	88/249 (35%)
Tak1	NP_524080.1	STKc_TAK1	25..275	CDD:270960	89/254 (35%)
MAP3K20	NP_057737.2	STKc_MLTK	22..263	CDD:270962	88/249 (35%)
		STYKc	23..260	CDD:214568	88/245 (36%)
		Leucine-zipper	287..308		2/20 (10%)
		SAM_MLTK	338..408	CDD:188928	14/104 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	652..800
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810