DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tak1 and TNNI3K

DIOPT Version :9

Sequence 1:	NP_524080.1	Gene:	Tak1 / 39659	FlyBaseID:	FBgn0026323	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_057062.1	Gene:	TNNI3K / 51086	HGNCID:	19661	Length:	835	Species:	Homo sapiens

Alignment Length:	317	Identity:	100/317 - (31%)
Similarity:	157/317 - (49%)	Gaps:	39/317 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 YVDFSEITLREKVGHGSYGVVCKAVWRDKLVAVKEFFAS--AEQKDIE---KEVKQLSRVKHPNI 72
            ::..|||...|.:|.||:|.|.|...|:|:||:|.:.|:  ..:.|::   :||..|.::.||.:
Human   457 HLQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCV 521

  Fly    73 IALHGISSYQQATY-LIMEFAEGGSLHNFLHGKVKPAYSLAHAMSWARQCAEGLAYLHAMTPKPL 136
            |...|......:.: ::.::..||||.:.|| :.|....|...:..|...|:|:.|||.:| :|:
Human   522 IQFVGACLNDPSQFAIVTQYISGGSLFSLLH-EQKRILDLQSKLIIAVDVAKGMEYLHNLT-QPI 584

  Fly   137 IHRDVKPLNLLLTNKGRNLKICDFGTVADKSTM----MTNNRGSAAWMAPEVF-EGSKYTEKCDI 196
            ||||:...|:||...|..: :.|||......::    ||...|:..||||||| :.::||.|.|:
Human   585 IHRDLNSHNILLYEDGHAV-VADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTRYTIKADV 648

  Fly   197 FSWAIVLWEVLSRKQPFKGIDNAYTIQWKIYKGERPPLLTTCPKRIEDLMTACWKTVPEDRPSMQ 261
            ||:|:.|||:|:.:.||..:..|.......|...|||:..:.||.|..|:...|...||.||...
Human   649 FSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISSLLIRGWNACPEGRPEFS 713

  Fly   262 YIVGVMHEIVKDYTGADKALEYTFVNQQIVTKESDGTVAAQPDSLSSQEGELSPSST 318
            .:|              ..||....|.::::..|           |:..|.|||||:
Human   714 EVV--------------MKLEECLCNIELMSPAS-----------SNSSGSLSPSSS 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tak1	NP_524080.1	TyrKc	19..264	CDD:197581	86/255 (34%)
Tak1	NP_524080.1	STKc_TAK1	25..275	CDD:270960	85/260 (33%)
TNNI3K	NP_057062.1	ANK	<56..121	CDD:238125
		ANK repeat	66..98	CDD:293786
		ANK 1	66..96
		ANK	99..220	CDD:238125
		ANK repeat	100..131	CDD:293786
		ANK 2	100..129
		ANK 3	133..162
		ANK repeat	134..164	CDD:293786
		ANK	161..290	CDD:238125
		ANK repeat	166..197	CDD:293786
		ANK 4	166..195
		ANK repeat	199..232	CDD:293786
		ANK 5	199..228
		ANK	229..360	CDD:238125
		ANK 6	234..263
		ANK repeat	234..262	CDD:293786
		ANK repeat	269..302	CDD:293786
		ANK 7	269..298
		ANK repeat	304..337	CDD:293786
		ANK 8	304..335
		ANK	334..>401	CDD:238125
		ANK repeat	339..369	CDD:293786
		ANK 9	339..368
		ANK 10	381..410
		PKc_TNNI3K	469..722	CDD:270966	87/269 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	732..751		8/25 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810