DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tak1 and MAP3K11

DIOPT Version :9

Sequence 1:	NP_524080.1	Gene:	Tak1 / 39659	FlyBaseID:	FBgn0026323	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_002410.1	Gene:	MAP3K11 / 4296	HGNCID:	6850	Length:	847	Species:	Homo sapiens

Alignment Length:	342	Identity:	110/342 - (32%)
Similarity:	167/342 - (48%)	Gaps:	66/342 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 FSEITLREKVGHGSYGVVCKAVWRDKLVAVK--------EFFASAEQKDIEKEVKQLSRVKHPNI 72
            |.|:.|.|.:|.|.:|.|.:..||.:|||||        :...:||  .:.:|.:..:.:.||||
Human   114 FQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAE--SVRQEARLFAMLAHPNI 176

  Fly    73 IALHGISSYQQATYLIMEFAEGGSLHNFLHGKVKPAYSLAHAMSWARQCAEGLAYLHAMTPKPLI 137
            |||..:...:....|:||:|.||.|...|.|:..|.:.|   ::||.|.|.|:.|||.....|:|
Human   177 IALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVL---VNWAVQIARGMHYLHCEALVPVI 238

  Fly   138 HRDVKPLNLLLTN-------KGRNLKICDFGTVAD--KSTMMTNNRGSAAWMAPEVFEGSKYTEK 193
            |||:|..|:||..       :.:.|||.|||...:  |:|.| :..|:.|||||||.:.|.:::.
Human   239 HRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQM-SAAGTYAWMAPEVIKASTFSKG 302

  Fly   194 CDIFSWAIVLWEVLSRKQPFKGID----------NAYTIQWKIYKGERPPLLTTCPKRIEDLMTA 248
            .|::|:.::|||:|:.:.|::|||          |..|:          |:.:|||:....||..
Human   303 SDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTL----------PIPSTCPEPFAQLMAD 357

  Fly   249 CWKTVPEDRPSMQYIV--------GVMHEIVKDYTGADKALEYTFVNQQIVTK-ESDGTVAAQPD 304
            ||...|..||....|:        .|:.|:.:|          :|.:.|...| |..|..    |
Human   358 CWAQDPHRRPDFASILQQLEALEAQVLREMPRD----------SFHSMQEGWKREIQGLF----D 408

  Fly   305 SLSSQEGELSPSSTQLT 321
            .|.::|.||.....:||
Human   409 ELRAKEKELLSREEELT 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tak1	NP_524080.1	TyrKc	19..264	CDD:197581	92/271 (34%)
Tak1	NP_524080.1	STKc_TAK1	25..275	CDD:270960	94/284 (33%)
MAP3K11	NP_002410.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	11..38
		SH3_MLK1-3	45..102	CDD:212992
		STKc_MLK3	113..379	CDD:271049	95/280 (34%)
		STYKc	117..376	CDD:214568	93/274 (34%)
		Leucine-zipper 1	403..424		6/24 (25%)
		Leucine-zipper 2	438..459
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	537..643
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	655..847
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810