DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tak1 and MAP3K10

DIOPT Version :9

Sequence 1:	NP_524080.1	Gene:	Tak1 / 39659	FlyBaseID:	FBgn0026323	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	XP_011525283.1	Gene:	MAP3K10 / 4294	HGNCID:	6849	Length:	962	Species:	Homo sapiens

Alignment Length:	357	Identity:	112/357 - (31%)
Similarity:	169/357 - (47%)	Gaps:	71/357 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ATASLDALQAAYVDFSEITLREKVGHGSYGVVCKAVWRDKLVAVKEFFASAEQKDIEK------- 59
            |.|.|...|.  :.|.|:.|.|.:|.|.:|.|.:|:||.:.||||     |.:.|.||
Human    83 APAGLQLPQE--IPFHELQLEEIIGVGGFGKVYRALWRGEEVAVK-----AARLDPEKDPAVTAE 140

  Fly    60 ----EVKQLSRVKHPNIIALHGISSYQQATYLIMEFAEGGSLHNFLHGKVKPAYSLAHAMSWARQ 120
                |.:....::|||||||.|.........|:||:|.||:|...|.|:..|.:.|   ::||.|
Human   141 QVCQEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGGALSRVLAGRRVPPHVL---VNWAVQ 202

  Fly   121 CAEGLAYLHAMTPKPLIHRDVKPLNLLLTNKGRN-------LKICDFGTVAD--KSTMMTNNRGS 176
            .|.|:.|||...|.|:||||:|.:|:|:.....|       |||.|||...:  |:|.| :..|:
Human   203 VARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKM-SAAGT 266

  Fly   177 AAWMAPEVFEGSKYTEKCDIFSWAIVLWEVLSRKQPFKGIDNAYTIQWKIYKGERP-PLLTTCPK 240
            .|||||||...|.:::..|::|:.::|||:|:.:.|::.|| |..:.:.:...:.. |:.:|||:
Human   267 YAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREID-ALAVAYGVAMNKLTLPIPSTCPE 330

  Fly   241 RIEDLMTA--------CWKTVPEDRPS----------------MQYIVGVMHEIVKDYTGADKAL 281
            ....|:..        ||...|..||.                .|..:...|.:.:|:     .|
Human   331 PFARLLEGEPGPRDEECWDPDPHGRPDFGSILKRLEVIEQSALFQMPLESFHSLQEDW-----KL 390

  Fly   282 EYTFVNQQIVTKESDGTVAAQPDSLSSQEGEL 313
            |...:...:.|||.:         |.|:|.||
Human   391 EIQHMFDDLRTKEKE---------LRSREEEL 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tak1	NP_524080.1	TyrKc	19..264	CDD:197581	94/289 (33%)
Tak1	NP_524080.1	STKc_TAK1	25..275	CDD:270960	94/294 (32%)
MAP3K10	XP_011525283.1	SH3_MLK1-3	20..76	CDD:212992
		TyrKc	98..365	CDD:197581	93/276 (34%)
		PKc_like	103..368	CDD:304357	91/274 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810