DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tak1 and Lrrk

DIOPT Version :9

Sequence 1:	NP_524080.1	Gene:	Tak1 / 39659	FlyBaseID:	FBgn0026323	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_001262772.1	Gene:	Lrrk / 42447	FlyBaseID:	FBgn0038816	Length:	2513	Species:	Drosophila melanogaster

Alignment Length:	306	Identity:	88/306 - (28%)
Similarity:	133/306 - (43%)	Gaps:	78/306 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 VGHGSYGVVCKA----------------------------------------VW-RDKLVAVKEF 48
            :|.|::|.|.||                                        .| ||.|....:.
  Fly  1802 LGRGAFGFVFKANCKVRGARSFKPVAMKMLQPVPPGARAKESALMAFKVAVGKWDRDPLQHSCKA 1866

  Fly    49 FASAEQKDIEKEVKQLSRVKHPNIIALHGISSYQQATYLIMEFAEGGSLHNFL-HGKVKPAYSLA 112
            :.:|.|     |:..|..:|||||:.|.||.....|  |::|.|..|.|...| |.:...|:...
  Fly  1867 YCTARQ-----ELAVLLTLKHPNIVPLVGICIKPLA--LVLELAPLGGLDALLRHYRRSGAHMGP 1924

  Fly   113 HA-MSWARQCAEGLAYLHAMTPKPLIHRDVKPLNLLL--------TNKGRNL---KICDFGTVAD 165
            |. .:...|.|..:.|||.   :.:|:||:|..|:|:        .:..|||   ||.|:|  ..
  Fly  1925 HTFQTLVLQAARAIEYLHR---RRIIYRDLKSENVLVWELPQPHTEDSPRNLVHIKIADYG--IS 1984

  Fly   166 KSTMMTNNR---GSAAWMAPEV--FEG-SKYTEKCDIFSWAIVLWEVLSRKQPFKGIDNAYTIQW 224
            :.|..:..:   |:..:||||:  :.| .:||||.|.||:.:.::|.:|.:|||:|.:   :|:.
  Fly  1985 RQTAPSGAKGFGGTEGFMAPEIIRYNGEEEYTEKVDCFSFGMFIYENISLRQPFEGHE---SIKE 2046

  Fly   225 KIYKGERPPLL---TTCPKRIEDLMTACWKTVPEDRPSMQYIVGVM 267
            .|.:|.||.|.   |..|....|||..||...|..||:...||.::
  Fly  2047 CILEGSRPALTQRETQFPTCCLDLMVLCWHEQPRRRPTASQIVSIL 2092

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tak1	NP_524080.1	TyrKc	19..264	CDD:197581	86/301 (29%)
Tak1	NP_524080.1	STKc_TAK1	25..275	CDD:270960	88/306 (29%)
Lrrk	NP_001262772.1	Ank_2	111..200	CDD:289560
		ANK	146..286	CDD:238125
		ANK repeat	146..177	CDD:293786
		Ank_4	179..232	CDD:290365
		ANK repeat	179..209	CDD:293786
		Ank_2	216..389	CDD:289560
		ANK	361..477	CDD:238125
		ANK repeat	361..390	CDD:293786
		Ank_2	364..464	CDD:289560
		ANK repeat	406..435	CDD:293786
		ANK repeat	437..464	CDD:293786
		LRR_8	<544..580	CDD:290566
		leucine-rich repeat	547..569	CDD:275380
		LRR_8	569..629	CDD:290566
		leucine-rich repeat	570..595	CDD:275380
		leucine-rich repeat	596..618	CDD:275380
		leucine-rich repeat	619..641	CDD:275380
		leucine-rich repeat	642..676	CDD:275380
		leucine-rich repeat	677..730	CDD:275380
		LRR_8	729..788	CDD:290566
		leucine-rich repeat	731..754	CDD:275380
		LRR_8	855..933	CDD:290566
		leucine-rich repeat	855..901	CDD:275380
		leucine-rich repeat	902..924	CDD:275380
		leucine-rich repeat	925..949	CDD:275380
		P-loop_NTPase	993..1211	CDD:304359
		COR	1230..1471	CDD:292713
		STYKc	1796..2092	CDD:214568	88/304 (29%)
		STKc_LRRK	1801..2095	CDD:270902	88/306 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445230
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.830