DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tak1 and ptk2aa

DIOPT Version :9

Sequence 1:	NP_524080.1	Gene:	Tak1 / 39659	FlyBaseID:	FBgn0026323	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_942114.1	Gene:	ptk2aa / 386705	ZFINID:	ZDB-GENE-031114-5	Length:	1045	Species:	Danio rerio

Alignment Length:	697	Identity:	154/697 - (22%)
Similarity:	255/697 - (36%)	Gaps:	164/697 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TASLDALQAAYVDFSEITLREKVGHGSYGVVCKAVW-----RDKLVAV---KEFFASAEQKDIEK 59
            |.::.:.|...:....|.|...:|.|.:|.|.:.|:     ....||:   |...:.:.::...:
Zfish   410 TYTMPSTQDYEIQRDRIELGRCIGEGQFGDVHQGVYISPENPSLSVAIKTCKNCTSDSVREKFLQ 474

  Fly    60 EVKQLSRVKHPNIIALHGISSYQQATYLIMEFAEGGSLHNFLHGKVKPAYSLAHAMSWARQCAEG 124
            |...:.:..||:|:.|.||.: :...::|||....|.|.:||..: |....|:..:.:|.|.:..
Zfish   475 EALTMRQFDHPHIVKLIGIIT-ENPVWIIMELCTLGELRSFLQVR-KYNLDLSTLILFAYQLSTA 537

  Fly   125 LAYLHAMTPKPLIHRDVKPLNLLLTNKGRNLKICDFG--TVADKSTMMTNNRGS--AAWMAPEVF 185
            ||||.:   |..:|||:...|:|:::.. .:|:.|||  ...:.|:....::|.  ..|||||..
Zfish   538 LAYLES---KRFVHRDIAARNVLVSSID-CVKLGDFGLSRYMEDSSYYKASKGKLPIKWMAPESI 598

  Fly   186 EGSKYTEKCDIFSWAIVLWEVLS-RKQPFKGIDNAYTIQWKIYKGERPPLLTTCPKRIEDLMTAC 249
            ...::|...|::.:.:.:||:|. ..:||:|:.|...| .:|..|||..:...||..:..|||.|
Zfish   599 NFRRFTSASDVWMFGVCMWEILMFGIKPFQGVKNNDVI-GRIENGERLAMPQNCPPTLYSLMTKC 662

  Fly   250 WKTVPEDRPSMQYIVGVMHEIV-KDYTGADKALEYTFVNQQIVTKESDGTVAAQPDSLSSQEGEL 313
            |...|..||....:...:..|: ::....::........|..|:.::..:..|.|.  .|:.|..
Zfish   663 WAYDPSKRPRFTELKTQLSTILDEEKLQQEERFRMEMRRQVTVSWDAGNSDEAPPK--PSRPGYP 725

  Fly   314 SPSSTQ---LTPTTAANAN------VNAIAISKTTTSSMTENTSSTSSDITPTNSGQLDNNPLFY 369
            ||.|:.   .:|..|...|      ..|..:|.....:.|       |.:.|..|......|
Zfish   726 SPRSSDGYFPSPQHAGQHNHYQGSGYPAAHVSSPGFPAQT-------SILDPLESWNHRQEP--- 780

  Fly   370 MVTNRWDAIPEEESNESRNDSFNLTSSAEATQRLETIRNGMILMACKPMEQLTLD---VEANGFD 431
               ..|.|..|:.:...|....| |...|.|             ..|..:|:..|   :|.....
Zfish   781 ---PTWPANAEDGAAVGRTQPMN-THLMEET-------------LIKQQQQMEEDQRWLEQEESF 828

  Fly   432 LSPSESSSSSTNAKSD----------------GRERLTVTDTKPVMMTTDLSNNNGGIHAHSNGL 480
            |.|...:|.|:..:.|                |:..|.....||         ...|..||...|
Zfish   829 LKPESRNSRSSIDREDAALQTPMGKQHVYQPVGKTDLVAPPKKP---------PRPGAPAHLTNL 884

  Fly   481 LSHANGWQARDEELQEQEHEQEIVNSLDVDVDPDEDENDGTEQSLAEILDP-ELQPE----PPIP 540
                                           .|.:..|:|.:        | .|||:    ||..
Zfish   885 -------------------------------SPADSYNEGVK--------PWRLQPQEISPPPTA 910

  Fly   541 N-DAESQLIYRDHRHMAKEYLSVDTNLY------YAQDFKD------KLIVQMDRT--------- 583
            | |..:..:|.:...:.|..:.:.:.:.      |....||      .|:..:|.|
Zfish   911 NLDRSNDKVYENVTGLVKAVIEMSSRIQPALPEEYVPMVKDVGLALRTLLATVDETIPVLPAHTH 975

  Fly   584 ---EREQK------QELLRKMKDKEGLQSLYNNLQQQYASRQLAAGH 621
               |..||      .||:.||:..:  |.:..:|||.|..:.|.|.|
Zfish   976 REIEMAQKLLNSDLAELISKMRLAQ--QYMLTSLQQDYKKQMLTAAH 1020

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tak1	NP_524080.1	TyrKc	19..264	CDD:197581	73/257 (28%)
Tak1	NP_524080.1	STKc_TAK1	25..275	CDD:270960	72/263 (27%)
ptk2aa	NP_942114.1	B41	36..258	CDD:214604
		FERM_B-lobe	143..247	CDD:271216
		FERM_C_FAK1	254..364	CDD:270011
		PTKc_FAK	419..688	CDD:133187	74/275 (27%)
		Pkinase_Tyr	426..680	CDD:285015	73/260 (28%)
		Focal_AT	911..1040	CDD:281606	25/112 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910