DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tak1 and Ankk1

DIOPT Version :9

Sequence 1:	NP_524080.1	Gene:	Tak1 / 39659	FlyBaseID:	FBgn0026323	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_001102469.2	Gene:	Ankk1 / 367080	RGDID:	1305538	Length:	784	Species:	Rattus norvegicus

Alignment Length:	762	Identity:	160/762 - (20%)
Similarity:	291/762 - (38%)	Gaps:	220/762 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 FSEI-TLREKVGHGSYGVVCKAVWRDKLVAVKEFFASAEQKDIEKEVKQLSRVKHPNIIALHGIS 79
            ||:: ..|.|.....|.:.|..       .:::...|:|...:.:|..::.::|...|::::|:.
  Rat    45 FSQVFQARHKRWRTQYAIKCSP-------CLQKETTSSEVSCLFEEAVKMEKIKFQYIVSIYGVC 102

  Fly    80 SYQQATYLIMEFAEGGSLHNFLHGKVKPAYSLAHAMSW--ARQCAEGLAYLHAMTPKPLIHRDVK 142
              :|...::|||...|||.     |:.|.:||...:.:  ..:.:..:.:||::.| ||:|.|:|
  Rat   103 --KQPLGIVMEFMANGSLE-----KILPTHSLCWQLKFRIIHETSLAMNFLHSIKP-PLLHLDLK 159

  Fly   143 PLNLLLTNKGRNLKICDFGTV--ADKSTM-----MTNNRGSAAWMAPEVF------EGSKYTEKC 194
            |.|:||.| ..::||.|||..  .::||.     .:..||:.:::.||:|      .|.:|
  Rat   160 PGNILLDN-NMHVKISDFGLSKWMEQSTQKQYIERSALRGTLSYIPPEMFLENNKAPGPEY---- 219

  Fly   195 DIFSWAIVLWEVLSRKQPFKGIDNAYTIQWKIYKGERPPLLTTCPK------RIEDLMTACWKTV 253
            |::|:.||:||:|::|:|:.|: |..||..::..|.||.|.....:      ::.|||..||...
  Rat   220 DVYSFGIVVWEILTQKKPYAGL-NMMTIIIQVAAGMRPSLHDVSAEWPEEAHQMVDLMKLCWDQD 283

  Fly   254 PEDRPSMQYIVGVMHEIVKDYTGADKALEYTFVNQQIVTKESDGTVAAQPDSLSSQEGELSPSST 318
            |:.||....::.....::..:.......||..:.:::..|.|    .:||.
  Rat   284 PKKRPCFLNVIIETDMLLSLFQTPVADPEYEALTRKVSYKSS----LSQPH-------------- 330

  Fly   319 QLTPTTAANANVNAIAISKTTTSSMTENTS-----------STSSDITPTNSGQLDNNPLFYMVT 372
            :..||..     |.:.:||..:..:.::..           |.|..:.|::..:....||.::|
  Rat   331 RWIPTLH-----NTLQVSKEVSQEIADSADSDDSLKWILQLSDSKSLVPSDIYENKVTPLHFLV- 389

  Fly   373 NRWDAIPEEESNESRNDSFNLTSSAEATQRLETIRNGMILMACKPMEQLTLDVE-ANGFDLSPSE 436
                                      |...||.:|   :|::    .::.:|.: |:|:  :|.
  Rat   390 --------------------------ARGSLEQVR---LLLS----HEVDVDCQTASGY--TPL- 418

  Fly   437 SSSSSTNAKSDGRERLTVTDTKPVMMT--------TDLSNNNGGIHAH---SNG-------LLSH 483
                          .:...|.:|.:..        |:|::.:|....|   .:|       ||.|
  Rat   419 --------------LIATQDQQPDLCALLLAHGADTNLADEDGWAPLHFAAQSGDDHTARLLLDH 469

  Fly   484 ANGWQARDEE------LQEQEHEQEIVN---SLDVDVDPDEDENDGTEQSLAEILDPELQPEPPI 539
            .....||:.|      |..|.:.:.|..   |...|::|.|.|.                 :.|:
  Rat   470 GALVNAREHEGWTPLHLAAQNNFENIARLLVSRQADLNPCEAEG-----------------KTPL 517

  Fly   540 PNDAESQLIYRDHRHMAKEYLSVDTNLYYAQ-DFKDKLIVQMDRTEREQKQELLRK-----MKDK 598
            ...|     |..|..:.|........|...| :.:..|.:.:::.:....|.||::     :.|.
  Rat   518 HVAA-----YFGHIGLVKLLTGQGAELDAQQRNLRTPLHLAVEKGKVRAIQHLLKRGALPDVLDH 577

  Fly   599 EGLQSL-----------YNNLQQQYASRQLAAGHHPQP-HPHPHPNQLQHPH----SH------- 640
            .|...|           :..|.:..||.:|.......| |...:...|:..|    ||
  Rat   578 NGYSPLHIAAAKGKYLIFKMLLRHGASLELCTQQGWAPLHLATYKGHLEIIHLLAKSHADLDALG 642

  Fly   641 ----PPMH---FLQDEGCGLLPGSVCGGSESVEE--GWVVIPPHHNA 678
                .|:|   |..:||. :|....||.:.:..|  ||.   |.|.|
  Rat   643 SMQWTPLHLAAFCGEEGM-MLALLQCGANPNAAEQSGWT---PLHLA 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tak1	NP_524080.1	TyrKc	19..264	CDD:197581	73/266 (27%)
Tak1	NP_524080.1	STKc_TAK1	25..275	CDD:270960	71/270 (26%)
Ankk1	NP_001102469.2	PKc_like	37..305	CDD:389743	75/280 (27%)
		ANK repeat	383..411	CDD:293786	9/61 (15%)
		Ank_2	385..476	CDD:372319	21/141 (15%)
		ANK repeat	413..444	CDD:293786	6/47 (13%)
		PHA03095	432..>689	CDD:222980	57/280 (20%)
		ANK repeat	446..477	CDD:293786	7/30 (23%)
		ANK repeat	479..510	CDD:293786	7/30 (23%)
		ANK repeat	512..542	CDD:293786	7/51 (14%)
		ANK repeat	547..576	CDD:293786	4/28 (14%)
		ANK repeat	578..609	CDD:293786	6/30 (20%)
		ANK repeat	612..642	CDD:293786	6/29 (21%)
		ANK repeat	644..675	CDD:293786	8/31 (26%)
		Ank_2	649..741	CDD:372319	13/41 (32%)
		ANK repeat	677..708	CDD:293786	5/12 (42%)
		ANK repeat	710..741	CDD:293786
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910