Protein Alignment Tak1 and Ripk2

DIOPT Version :9

• Sequence 1: NP_524080.1
• Gene: Tak1 / 39659
• FlyBaseID: FBgn0026323
• Length: 678
• Species: Drosophila melanogaster
• Sequence 2: NP_001178794.1
• Gene: Ripk2 / 362491
• RGDID: 1309167
• Length: 539
• Species: Rattus norvegicus
• Alignment Length: 681
• Identity: 153/681 - (22%)
• Similarity: 263/681 - (38%)
• Gaps: 199/681 - (29%)

  Fly     7 DALQAA--YVDFSEITLREKVGHGSYGVVCK---AVWRDKLVAVKEF-----FASAEQKDIEKEV 61
            ||:.:|  ::.:.::.....:..|:.|.|..   |.||.: ||||..     ...:|:.||.:|.
  Rat     4 DAICSALPHIPYHKLADLHYLSRGASGTVSSARHADWRVR-VAVKHLHIHTPLLDSERNDILREA 67

  Fly    62 KQLSRVKHPNIIALHGISSYQQATYLIMEFAEGGSLHNFLHGKVK-PAYSLAHAMSWARQCAEGL 125
            :.|.:.:...|:.:.||.:..:...::.|:...|||:..||.|.: |..:.........:.|.|:
  Rat    68 EILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPEIAWPLRFRILHEIALGV 132

  Fly   126 AYLHAMTPKPLIHRDVKPLNLLLTNKGRNLKICDFGTVADKSTMMTNNR--------GSAAWMAP 182
            .|||.|.| ||:|.|:|..|:||.|: .::||.|||....:...::.:|        |:..:|.|
  Rat   133 NYLHNMNP-PLLHHDLKTQNILLDNE-FHVKIADFGLSKWRMMSLSQSRSYKSAPEGGTIIYMPP 195

  Fly   183 EVFE---GSKYTEKCDIFSWAIVLWEVLSRKQPFKGIDNAYTIQWKIYKGERP-----PLLTTCP 239
            |.:|   .|:.:.|.||:|:|:::||||||||||:.:.|...|.:.:.:|.||     .|....|
  Rat   196 ENYEPGQKSRASVKHDIYSYAVIMWEVLSRKQPFEEVTNPLQIMYSVSQGHRPNTSEENLPFDIP 260

  Fly   240 KR--IEDLMTACWKTVPEDRPSMQYIVGVMHEIVKDYTGADKALEYTFVNQQIVTKESDGTVAAQ 302
            .|  :..|:.:.|...|::|||....:..:..:::.:.      :.||:...|..|:|....|:.
  Rat   261 HRGLMISLIQSGWAQNPDERPSFLKCLIELEPVLRTFE------DITFLEAVIQLKKSKIQSASS 319

  Fly   303 PDSLSSQEGELS---PSSTQLTPTTAANANVNAIAISKTTTSSMT------------ENTSSTSS 352
            ...|..::.:||   |:|......:..::.::..|.|..|:.|::            ::.||:.:
  Rat   320 TIHLCDKKMDLSLNIPASHPPQEESCGSSLLSRNAGSPGTSRSLSAPQDKGFFHGGPQDCSSSKA 384

  Fly   353 DITPTNSGQLDNNPLFYMVTNRWDAIPEEESNESRNDSFNLTSSAEATQRLETIRNGMILMACKP 417
            ...|.|              :.||.|
  Rat   385 YHCPGN--------------HSWDGI--------------------------------------- 396

  Fly   418 MEQLTLDVEANGFDLSPSESSSSSTNAKSDGRERLTVTDTKPVMMTTDLSNNNGGIHAHSNGLLS 482
               :::..||...|...|..|             |||  .:|:::.........||
  Rat   397 ---ISVSQEAAFCDRRASSCS-------------LTV--IRPLLVEKSSERPQPGI--------- 434

  Fly   483 HANGWQARDEELQEQEHEQEIVNSLDVDVDPDEDENDGTEQSLAEILDPELQPEPPIPNDAESQL 547
             |..|        .|...:.||:.:             ||..|.:.||..|..:..:..|.|  |
  Rat   435 -AQQW--------IQSKREAIVSQM-------------TEACLNQSLDALLSRDLIMKEDYE--L 475

  Fly   548 IYRDHRHMAKEYLSVDTNLYYAQDFKDKLIVQMDRTEREQKQELLRKMKDKEGLQSLYNNLQQQY 612
            |.......||....:||:....::|. ::|||              |:||
  Rat   476 ISTKPTRTAKVRQLLDTSDIQGEEFA-RVIVQ--------------KLKD--------------- 510

  Fly   613 ASRQLAAGHHPQPHPH-------PHPNQLQH 636
             ::|:..    ||:|.       |..|.||:
  Rat   511 -NKQMGL----QPYPEVLLVSRTPSSNVLQN 536

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tak1	NP_524080.1	TyrKc	19..264	CDD:197581	83/271 (31%)
		STKc_TAK1	25..275	CDD:270960	83/276 (30%)
Ripk2	NP_001178794.1	STKc_RIP2	20..303	CDD:270928	84/291 (29%)
		STYKc	21..290	CDD:214568	83/271 (31%)
		CARD_RIP2_CARD3	437..523	CDD:176764	29/143 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810