Protein Alignment Tak1 and LIMK1

DIOPT Version :9

• Sequence 1: NP_524080.1
• Gene: Tak1 / 39659
• FlyBaseID: FBgn0026323
• Length: 678
• Species: Drosophila melanogaster
• Sequence 2: NP_511139.2
• Gene: LIMK1 / 32207
• FlyBaseID: FBgn0283712
• Length: 1257
• Species: Drosophila melanogaster
• Alignment Length: 739
• Identity: 160/739 - (21%)
• Similarity: 278/739 - (37%)
• Gaps: 222/739 - (30%)

  Fly    17 SEITLREKVGHGSYGVVCKAVWRD--KLVAVKEFFASAE--QKDIEKEVKQLSRVKHPNIIALHG 77
            :::.:.||:|.|.:|.|.|...|.  :::.:||...:.|  |::..|||..|..:.|.:::...|
  Fly   399 TDLVIGEKLGEGFFGKVFKVTHRQSGEVMVLKELHRADEEAQRNFIKEVAVLRLLDHRHVLKFIG 463

  Fly    78 ISSYQQATYLIMEFAEGGSLHNFLHGKVKPAYSLAHAMSW------ARQCAEGLAYLHAMTPKPL 136
            :....:..:::.|:..||.|...:|..       |..:.|      ||..|.|::|||:|.   :
  Fly   464 VLYKDKKLHMVTEYVAGGCLKELIHDP-------AQVLPWPQRVRLARDIACGMSYLHSMN---I 518

  Fly   137 IHRDVKPLNLLLTNKGRNLKICDFGTVAD-------KSTMMTNNRGSAA---------------- 178
            ||||:..:|.|: .:.|::.:.|||....       ...|.....||.|
  Fly   519 IHRDLNSMNCLV-REDRSVIVADFGLARSVDAPRLPSGNMTPGGYGSGANSDAPMSPSGTLRRSK 582

  Fly   179 ---------------WMAPEVFEGSKYTEKCDIFSWAIVLWEVLSRKQ---PFKGIDNAYTIQWK 225
                           |||||:.:|.||.||.|:||:.|:|.|::.|.:   .|...::.:::..:
  Fly   583 SRQRRQRYTVVGNPYWMAPEMMKGLKYDEKVDVFSFGIMLCEIIGRVEADPDFMPRNSDFSLNQQ 647

  Fly   226 IYKGERPPLLTTCPKRIEDLMTACWKTVPEDRPSMQYIVGVMHEIVKDYTGADKALEYTFVNQQI 290
            .:   |......||:....:...|....|:.||..: .:.|..:.:.|...||:......:::
  Fly   648 EF---REKFCAQCPEPFVKVAFVCCDLNPDMRPCFE-TLHVWLQRLADDLAADRVPPERLLHE-- 706

  Fly   291 VTKESDGTVAAQPDSLSSQEGELSPSSTQLTPTTAANANVNAIAISKTTTSSMTENTSSTSSDIT 355
                    :....:..:|.|..|||:|.:     :.| |::.:.            .|:..|:|:
  Fly   707 --------IETFQEWYASSEDALSPTSQR-----SLN-NLDELV------------KSAVDSEIS 745

  Fly   356 PTNSGQLDNNPLFYMVTNRWDAIPE--------EESNESRNDSF----------------NLTSS 396
            |... :.:|     ||....| ||:        ..|.|...||.                |||..
  Fly   746 PVEK-EKEN-----MVIKPQD-IPKSPHLGKDFSPSGERLRDSMRARRRQRFLGAQEERRNLTPD 803

  Fly   397 AEATQRLETIRNGMILMACKPMEQ--LTLDVEANGFDLSPSESSSSSTNAKSDGRERLTVTDTKP 459
            .|:.:|  .::..  |..|:|..:  ..:|:.| |.:|.           ..|.|:..|.:|
  Fly   804 TESKER--ALKKA--LKKCRPFGERGYLVDLRA-GAELQ-----------LEDVRDLNTYSD--- 849

  Fly   460 VMMTTDLSNNNGGIHAHSNGLLSHANGWQARDEELQEQEHEQEIVNSLDVDVDPDEDEN---DGT 521
            |..:.|.|.|                            .|:   ||:|..   ..||||   .|.
  Fly   850 VDSSCDTSLN----------------------------YHD---VNNLPA---AQEDENTVKPGK 880

  Fly   522 EQSLAEILDPELQPEPPIPNDAESQLIYRDHRHMAKEYLSVD---TNLYYAQDFKDKLIVQMDRT 583
            |:.|.|..:.        |::.|||    .||      |::|   |.|...:. |.:.:.:..|.
  Fly   881 EELLEESTNK--------PSNQESQ----HHR------LAIDDMRTRLNQCRS-KFEHLEEASRR 926

  Fly   584 EREQKQELLRK-MKDKEGLQSLYNNLQQQYASRQLAAGHHPQPHPHPHPNQL-QHP---HSHPPM 643
            ...|.|..::. .|.......::..|:.:.|:  |..|::..| |.|...:: |.|   ..:||:
  Fly   927 NFNQSQHSMKNFFKTPPVALKMFQRLEHEAAA--LNGGNNCPP-PPPRTQRINQTPIFGRKNPPV 988

  Fly   644 HFLQDEGCGLLPGSVCGGSESVEE 667
                     .:.|.....:||:|:
  Fly   989 ---------AIVGQKLQHAESLED 1003

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tak1	NP_524080.1	TyrKc	19..264	CDD:197581	72/295 (24%)
		STKc_TAK1	25..275	CDD:270960	72/300 (24%)
LIMK1	NP_511139.2	LIM1_LIMK	33..88	CDD:188750
		LIM2_LIMK	95..148	CDD:188751
		PDZ_signaling	172..271	CDD:238492
		STKc_LIMK	407..693	CDD:271056	72/300 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445220
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840