DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tak1 and Takl1

DIOPT Version :9

Sequence 1:	NP_524080.1	Gene:	Tak1 / 39659	FlyBaseID:	FBgn0026323	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_732554.1	Gene:	Takl1 / 318725	FlyBaseID:	FBgn0046689	Length:	393	Species:	Drosophila melanogaster

Alignment Length:	405	Identity:	136/405 - (33%)
Similarity:	211/405 - (52%)	Gaps:	38/405 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 VDFSEITLREK-VGHGSYGVVCKAVWRDKLVAVK--EFFASAEQKDIEKEVKQLSRVKHPNIIAL 75
            |||:|:.|.|| :|.||.|.|.||.::::.:|||  :|.....:|:.|:|:..||.:.|.|:|.:
  Fly     5 VDFAEVKLSEKFLGAGSGGAVRKATFQNQEIAVKIFDFLEETIKKNAEREITHLSEIDHENVIRV 69

  Fly    76 HGISSYQQATYLIMEFAEGGSLHNFLHGKVKPAYSLAHAMSWARQCAEGLAYLHAMTPKPLIHRD 140
            .|.:|..:..||:||:.|.|||||:|:|..|..|::..|:.||.|||:.|||||:: .:|::|||
  Fly    70 IGRASNGKKDYLLMEYLEEGSLHNYLYGDDKWEYTVEQAVRWALQCAKALAYLHSL-DRPIVHRD 133

  Fly   141 VKPLNLLLTNKGRNLKICDFGTVADKSTMMTNNRGSAAWMAPEVFEGSKYTEKCDIFSWAIVLWE 205
            :||.|:||.|:..:|||||||...|.|...|:.:|:..:||||..:..|||.|||::|:.|:|||
  Fly   134 IKPQNMLLYNQHEDLKICDFGLATDMSNNKTDMQGTLRYMAPEAIKHLKYTAKCDVYSFGIMLWE 198

  Fly   206 VLSRKQPFKGIDN---AYTIQWKIYKGERPPL---LTTCPKRIEDLMTACWKTVPEDRPSMQYIV 264
            :::|:.|:..::|   .|.|...|..||:.|:   .:.||:.|:.||..|....||.||||:.|.
  Fly   199 LMTRQLPYSHLENPNSQYAIMKAISSGEKLPMEAVRSDCPEGIKQLMECCMDINPEKRPSMKEIE 263

  Fly   265 GVMHEIVKDYTGAD--KALEYTFVNQQIVTKESDGTVAAQPDSLSSQEGELSPSSTQLTPTTAAN 327
            ..:.|..:..|..|  |.|:...|.......:|.|:...:.|....|    .||.....|.....
  Fly   264 KFLGEQYESGTDEDFIKPLDEDTVAVVTYHVDSSGSRIMRVDFWRHQ----LPSIRMTFPIVKRE 324

  Fly   328 ANVNAIAISKTTTSSMTENTSSTSSDITPTNSGQLDNNPLFYMVTNRWDAIPEEESNESRNDSFN 392
            |.    .:.||....|.:..:....::                  .|.:...|.|::.:.::...
  Fly   325 AE----RLGKTVVREMAKAAADGDREV------------------RRAEKDTERETSRAAHNGER 367

  Fly   393 LTSSAEATQRLETIR 407
            .|..|......||:|
  Fly   368 ETRRAGQDVGRETVR 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tak1	NP_524080.1	TyrKc	19..264	CDD:197581	106/253 (42%)
Tak1	NP_524080.1	STKc_TAK1	25..275	CDD:270960	105/257 (41%)
Takl1	NP_732554.1	S_TKc	15..262	CDD:214567	104/247 (42%)
Takl1	NP_732554.1	STKc_TAK1	17..274	CDD:270960	105/257 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45444230
Domainoid	1	1.000	140	1.000	Domainoid score	I1532
eggNOG	1	0.900	-	-		E2759_KOG0192
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D346131at33208
OrthoFinder	1	1.000	-	-		FOG0000676
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.750