DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tak1 and Map3k7

DIOPT Version :9

Sequence 1:	NP_524080.1	Gene:	Tak1 / 39659	FlyBaseID:	FBgn0026323	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_001101390.2	Gene:	Map3k7 / 313121	RGDID:	1309438	Length:	606	Species:	Rattus norvegicus

Alignment Length:	648	Identity:	226/648 - (34%)
Similarity:	328/648 - (50%)	Gaps:	111/648 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MATASLDALQAAYVDFSEITLREKVGHGSYGVVCKAVWRDKLVAVKEFFASAEQKDIEKEVKQLS 65
            |..|....|....:|:.||.:.|.||.|::||||||.||.|.||:|:..:.:|:|....|::|||
  Rat    18 MIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLS 82

  Fly    66 RVKHPNIIALHGISSYQQATYLIMEFAEGGSLHNFLHG-KVKPAYSLAHAMSWARQCAEGLAYLH 129
            ||.||||:.|:|  :......|:||:||||||:|.||| :..|.|:.||||||..||::|:||||
  Rat    83 RVNHPNIVKLYG--ACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLH 145

  Fly   130 AMTPKPLIHRDVKPLNLLLTNKGRNLKICDFGTVADKSTMMTNNRGSAAWMAPEVFEGSKYTEKC 194
            :|.||.|||||:||.||||...|..||||||||..|..|.||||:||||||||||||||.|:|||
  Rat   146 SMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNKGSAAWMAPEVFEGSNYSEKC 210

  Fly   195 DIFSWAIVLWEVLSRKQPFKGIDN-AYTIQWKIYKGERPPLLTTCPKRIEDLMTACWKTVPEDRP 258
            |:|||.|:||||::|::||..|.. |:.|.|.::.|.||||:...||.||.|||.||...|..||
  Rat   211 DVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRP 275

  Fly   259 SMQYIVGVMHEIVKDYTGADKALEYTFVNQQIVTKESDGTVAAQPDSLSSQEGELSPSSTQLTPT 323
            ||:.||.:|..:::.:.|||:.|:|                    ....|.||:.:
  Rat   276 SMEEIVKIMTHLMRYFPGADEPLQY--------------------PCQYSDEGQSN--------- 311

  Fly   324 TAANANVNAIAISKTTTSSMTENTSSTSSDITPTNSGQLDNNPLFYMVTNRWDAIPEEESN---- 384
                        |.|:|.|..:..|:.:|:.:.||..|:.       .||  |.|...||.
  Rat   312 ------------SATSTGSFMDIASTNTSNKSDTNMEQVP-------ATN--DTIKRLESKLLKN 355

  Fly   385 --ESRNDSFNLTSSAEATQRLETI---RNGMILMACKPMEQLTLDVEANGFDLSPSESSSSSTN- 443
              :.::||..|:..|.....:|::   ..|..:.|  .|.::...:.|......|......:.:
  Rat   356 QAKQQSDSGRLSLGASRGSSVESLPPTSEGKRMSA--DMSEIEARIVATTAYTKPKRGHRKTASF 418

  Fly   444 ----------AKSDGRER------LTVTDTKPVMMTTDLSNNNGGIHAHSNGLLSHANGWQARDE 492
                      ...:|:.|      ||||.|:|..:::..|:.:..:...|.
  Rat   419 GNILDVPEIVISGNGQPRRRSIQDLTVTGTEPGQVSSRSSSPSVRMITTSG-------------- 469

  Fly   493 ELQEQEHEQEIVNSLDVDVDPDEDENDGTEQSLAE---ILDPELQPEPPIPNDAESQLIYRDHRH 554
                 ...::...||....|...|.| |::.|:..   .||.:|||..|.||..||..::..|..
  Rat   470 -----PTSEKPARSLPWTPDDSTDTN-GSDNSIPMAYLTLDHQLQPLAPCPNSKESMAVFEQHCK 528

  Fly   555 MAKEYLSVDTNLYYAQDFKDKLIVQMDRTEREQK------QELLRKMKDKEGLQSLYNNLQQQ 611
            ||:||:.|.|.:......|.:|:.::|:.|::|:      ||..:.:.:.:.|.:.|...::|
  Rat   529 MAQEYMKVQTEIALLLQRKQELVAELDQDEKDQQNTSRLVQEHKKLLDENKSLSTYYQQCKKQ 591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tak1	NP_524080.1	TyrKc	19..264	CDD:197581	141/246 (57%)
Tak1	NP_524080.1	STKc_TAK1	25..275	CDD:270960	142/251 (57%)
Map3k7	NP_001101390.2	Interaction with MAPK8IP1. /evidence=ECO:0000250	1..300		153/283 (54%)
		TyrKc	36..284	CDD:197581	143/249 (57%)
		STKc_TAK1	42..292	CDD:270960	142/251 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	301..338		11/57 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	354..391		7/38 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	443..492		13/68 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	293	1.000	Domainoid score	I1456
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	349	1.000	Inparanoid score	I2225
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D346131at33208
OrthoFinder	1	1.000	-	-		FOG0000676
OrthoInspector	1	1.000	-	-		oto96856
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4191
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.830