DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tak1 and Raf

DIOPT Version :9

Sequence 1:	NP_524080.1	Gene:	Tak1 / 39659	FlyBaseID:	FBgn0026323	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_001096867.3	Gene:	Raf / 31221	FlyBaseID:	FBgn0003079	Length:	739	Species:	Drosophila melanogaster

Alignment Length:	332	Identity:	90/332 - (27%)
Similarity:	158/332 - (47%)	Gaps:	51/332 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 EITLREKVGHGSYGVVCKAVWRDKLVAVKEFF----ASAEQKDIEKEVKQLSRVKHPNIIALHGI 78
            ||.:..::|.||:|.|.:|.|... ||||...    :.|:.:..:.||..|.:.:|.||:...|.
  Fly   428 EILIGPRIGSGSFGTVYRAHWHGP-VAVKTLNVKTPSPAQLQAFKNEVAMLKKTRHCNILLFMGC 491

  Fly    79 SSYQQATYLIMEFAEGGSLHNFLHGKVKPAYSLAHAMSWARQCAEGLAYLHAMTPKPLIHRDVKP 143
            .| :.:..::.::.||.||:..:|.. :..:.|...:...||.|:|:.||||   |.:||||:|.
  Fly   492 VS-KPSLAIVTQWCEGSSLYKHVHVS-ETKFKLNTLIDIGRQVAQGMDYLHA---KNIIHRDLKS 551

  Fly   144 LNLLLTNKGRNLKICDFGTVADKSTMMTNNR-----GSAAWMAPEVF---EGSKYTEKCDIFSWA 200
            .|:.| ::..::||.|||....|:......:     ||..||||||.   |.:.|:.:.|::::.
  Fly   552 NNIFL-HEDLSVKIGDFGLATAKTRWSGEKQANQPTGSILWMAPEVIRMQELNPYSFQSDVYAFG 615

  Fly   201 IVLWEVLSRKQPFKGIDNAYTIQWKIYKGERPP----LLTTCPKRIEDLMTACWKTVPEDRPSMQ 261
            ||::|:|:...|:..|.|...|.:.:.:|...|    :.:..|:.::.|...|.|..|:|||..:
  Fly   616 IVMYELLAECLPYGHISNKDQILFMVGRGLLRPDMSQVRSDAPQALKRLAEDCIKYTPKDRPLFR 680

  Fly   262 YIVGVMHEIVKDYTGADKALEYTFVNQQIVTKESDGTVAAQPDSLSSQ----EGELSPSSTQLTP 322
            .::.::..:::......::                   |::|:...||    |....||     |
  Fly   681 PLLNMLENMLRTLPKIHRS-------------------ASEPNLTQSQLQNDEFLYLPS-----P 721

  Fly   323 TTAANAN 329
            .|..|.|
  Fly   722 KTPVNFN 728

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tak1	NP_524080.1	TyrKc	19..264	CDD:197581	78/260 (30%)
Tak1	NP_524080.1	STKc_TAK1	25..275	CDD:270960	77/265 (29%)
Raf	NP_001096867.3	RBD_RAF	142..212	CDD:340514
		C1_Raf	221..269	CDD:410361
		STKc_Raf	435..687	CDD:270964	77/258 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445239
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840